Ten-year experience in the management of gallbladder cancer from a single hepatobiliary and pancreatic centre with review of the literature

Ong, Seok Ling; Garcea, Giuseppe; Thomasset, Sarah; Neal, Christopher P.; Lloyd, David M.; Berry, David P.; Dennison, Ashley R.

doi:10.1080/13651820802392346

Cited by 18 publications

(30 citation statements)

References 36 publications

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“…Previous studies have demonstrated the association of both NLR and PLR with poor prognosis in various tumour types [27][28][29][30]. To our knowledge, this is the fi rst study to show PLR as an independent prognostic factor in patients with ovarian cancer.…”

Section: Discussionmentioning

confidence: 52%

Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer

et al. 2011

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Section: Discussionmentioning

confidence: 52%

Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer

et al. 2011

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“…Ong et al . did not describe the number of patients with a high or low NLR . The cut‐off value for a raised NLR varied in each study between greater than 1.94 and 3.74.…”

Section: Resultsmentioning

confidence: 98%

Prognostic significance of pre‐operative inflammatory markers in resected gallbladder cancer: a systematic review

Saqib

Pathak

Smart

et al. 2017

ANZ Journal of Surgery

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Elevated pre-operative inflammatory markers are inversely related to survival outcomes. They are relatively inexpensive, easy measurable parameters that could aid in the decision making process involved in the management of GBC. Sub-stratification of groups utilizing inflammatory markers may help guide surgical strategy. However, these studies are retrospective and of low to moderate quality. High quality, prospective studies with well-defined inclusion criteria and outcomes are needed to guide the role of inflammatory markers in the management of GBC.

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“…Surgical resection is the only curative therapy for GBC [15, 26, 27]. Determining the therapeutic approach for GBC in accordance with disease stage is supported by most authors [27, 28].…”

Section: Discussionmentioning

confidence: 99%

“…Determining the therapeutic approach for GBC in accordance with disease stage is supported by most authors [27, 28]. There is a consensus that simple cholecystectomy or LC is an adequate treatment for pT1a.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of surgical treatment for incidental gallbladder carcinoma diagnosed during or after laparoscopic cholecystectomy: single center results

et al. 2017

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BackgroundLaparoscopic cholecystectomy (LC) is the accepted standard management for benign gallbladder disease. LC rarely results in a diagnosis of incidental gallbladder carcinoma (IGBC). The aim of our study was to report our experience with IGBC diagnosed during or following LC.MethodsBetween January 2008 and January 2015, 352 patients underwent LC at Iwakuni Clinical Center. Among these patients, 8 (2.3%) were diagnosed with IGBC. We evaluated their characteristics, surgical related variables, histopathological findings and surgical outcomes.ResultsPatient median age was 71 (range 49–88) years, and 3 out of 8 were female. All patients with IGBC were Japanese. The grade of cancer was as follows: pT1a (3 cases), pT2 (4 cases) and pT3 (1 case). Two patients with pT2 disease underwent radical surgery. The median follow-up time of these patients was 24 (range 11–80) months. All patients are still alive and two of three patients who refused radical surgery have developed recurrence (liver metastases and recurrence in the peritoneum).ConclusionsAlthough the number of cases was small, the results of this study further support the suggestion that gallbladder carcinoma may be curable if diagnosed as IGBC at an early stage. If the cancer has reached an advanced stage, radical surgery should be performed.

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Ten-year experience in the management of gallbladder cancer from a single hepatobiliary and pancreatic centre with review of the literature

Abstract: Curative surgical resection of gallbladder cancer improved survival. Exploratory laparotomy which revealed inoperable disease reduced survival. Preoperative WCC, platelet, bilirubin and ALP may be used as additional discriminators during the investigation and work up prior to surgery.

Cited by 18 publications

References 36 publications

Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer

Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer

Prognostic significance of pre‐operative inflammatory markers in resected gallbladder cancer: a systematic review

Evaluation of surgical treatment for incidental gallbladder carcinoma diagnosed during or after laparoscopic cholecystectomy: single center results

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