Ten-year changes in the obesity, abdominal adiposity, and serum lipoprotein cholesterol measures of Western Samoan men

Galanis, Daniel J; Sobal, Jeffery; McGarvey, Stephen T.; Pelletier, David; Bausserman, Linda

doi:10.1016/0895-4356(95)00060-7

Cited by 26 publications

(19 citation statements)

References 47 publications

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“…In a study of young Samoan men with a mean baseline age of 26 years, 10-year changes in abdominal adiposity were positively associated with changes in TC and non-HDL-C, with correlations near 0.38. 26 These correlations were similar to those reported in the current investigation for the baseline-adjusted changes in the direct measures of adiposity with baseline-adjusted changes in TC and LDL-C. In a study of elderly Dutch men Ͼ58 years of age, Weijenberg and associates 31 reported a decrease in levels of TC of 0.04 mmol ⅐ L Ϫ1 ⅐ y…”

Section: Discussionsupporting

confidence: 74%

“…Previous studies investigating changes in lipids and changes in body composition have used a follow-up approach, wherein the differences between measurements taken at 2 points in time were used as measures of change, eg, the Québec Family Study 16 and a study using data from western Samoans. 26 Although rates of change can be calculated from the values obtained at the first and last examinations for individuals, all intermediate data for each individual are ignored in this approach. In the current study, 65% of the younger group and 75% of the older group had at least 3 measurements, and the intermediate data points comprised 35% of the 1304 total examinations of 423 individuals.…”

Section: Discussionmentioning

confidence: 99%

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Serial Changes in Body Composition Throughout Adulthood and Their Relationships to Changes in Lipid and Lipoprotein Levels

Siervogel

Wisemandle

Maynard

et al. 1998

ATVB

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Abstract-Few studies have examined the relationships between measures of body composition and lipid and lipoprotein levels in long-term serial data from individuals unselected for cardiovascular disease-or obesity-related variables, and none have considered such extensive serial data as used in the current study. The aim was to examine in such individuals the associations between annual changes in lipid and lipoprotein levels and concurrent changes in total body fat, fat-free mass, percent body fat, and body mass index. Serial data from 1304 examinations of 423 adult white participants in the Fels Longitudinal Study were analyzed sex-specifically in 2 age groups, 18 through 44 years and 45 to 65 years. A regressive analytic approach utilized the long-term (4 to 20 years) serial data of individuals. Annual changes in adiposity, independent of levels of lean tissue changes, before and after age 45 for men and women were significantly correlated with corresponding annual changes in cholesterol and low density lipoprotein cholesterol. In men before age 45, changes in triglycerides and high density lipoprotein cholesterol were also significantly associated with changes in adiposity, with the relationship remaining after age 45 in high density lipoprotein cholesterol. Increases in adiposity in individuals are associated with changes in lipid and lipoprotein levels in the direction of increased risk for cardiovascular disease. Adult levels of total cholesterol and low density lipoprotein cholesterol across age and sex and high density lipoprotein cholesterol in men are responsive to changes in adiposity, independent of initial adiposity or lipid and lipoprotein levels.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Serial Changes in Body Composition Throughout Adulthood and Their Relationships to Changes in Lipid and Lipoprotein Levels

Siervogel

Wisemandle

Maynard

et al. 1998

ATVB

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“…Among younger persons (aged 25–54 years), women have lower non‐HDL cholesterol levels than men; among persons older than age 55 years, women have higher levels than men 6 . In both sexes, non‐HDL cholesterol levels correlate closely with obesity and especially visceral obesity 7–10 . The link between non‐HDL cholesterol levels and physical activity appears to be less robust, although at least one study suggested that high‐intensity physical activity was associated with lower levels of non‐HDL cholesterol 11 …”

Section: What Factors Determine Non‐hdl Cholesterol Levels In the Us mentioning

confidence: 99%

Non‐High‐Density Lipoprotein Cholesterol: An Alternate Target for Lipid‐Lowering Therapy

Bittner

2004

Preventive Cardiology

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Non-high-density lipoprotein (non-HDL) cholesterol level is determined by subtracting the high-density lipoprotein cholesterol level from the total cholesterol level and thus encompasses not only low-density lipoprotein cholesterol, but also the cholesterol contained in atherogenic, triglyceride-rich particles like remnants. This review summarizes data extracted from English-language publications accessible through MEDLINE on the population distribution of non-HDL cholesterol, its relationship to cardiovascular disease, and the potential benefits of treatment. Non-HDL cholesterol levels in the population vary by age, sex, and race and are closely linked to measures of obesity, especially visceral obesity. Several studies in populations with and without cardiovascular disease show that non-HDL cholesterol levels relate to atherosclerosis severity and subsequent cardiovascular morbidity and mortality. Preliminary data also suggest that pharmacologically induced changes in non-HDL cholesterol levels relate to prognosis. In the National Cholesterol Education Program Adult Treatment Panel III report, non-HDL cholesterol has been designated a secondary target of therapy among patients with hypertriglyceridemia.

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“…In follow-up investigations, relationships between changes in adiposity and changes in or levels of blood pressure and/or lipids and lipoproteins have been shown over some age ranges (5,(13)(14)(15)(16). Some investigations have examined child or adolescent measures of adiposity on adult measures of adiposity and associations with CVD risk factors (14,17), whereas others have provided information regarding the relationships of adult changes in adiposity with changes in blood pressure and lipid and lipoprotein levels (5,16).…”

Section: Introductionmentioning

confidence: 99%

Lifetime Overweight Status in Relation to Serial Changes in Body Composition and Risk Factors for Cardiovascular Disease: The Fels Longitudinal Study

et al. 2000

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The aims were to determine if 1) individuals who became and maintained overweight during their entire lifetime differ from those who were never-overweight in terms of annual changes in adiposity and concurrent changes in cardiovascular disease (CVD) risk factors; 2) the changes and their relationships to each other varied between these groups or by sex within the groups; and 3) alcohol usage, smoking habits, and level of physical activity differed between groups. Research Methods and Procedures: Data from 16,315 examinations of 414 individuals were utilized to assess lifetime overweight (body mass index [BMI] Ͼ 25 kg/m 2 ) status. A regressive analytic approach was used to determine the average annual changes for each individual over an adult serial interval ranging from 4 to 20 years. Results: Men and women who have become and maintained overweight have higher blood pressure and a poorer lipid/ lipoprotein risk profile than those who have never been overweight. There is an accelerated deterioration in the atherogenic profile of overweight men and women as indicated by annual changes in CVD risk factors about double that of their never-overweight counterparts. In women, increased risk is derived from increasing systolic and diastolic blood pressure, whereas in men the increased risk comes not only from increasing diastolic blood pressure but also cholesterol, triglycerides, and low-density lipoprotein cholesterol levels and, to a lesser extent, decreasing high-density lipoprotein cholesterol. Discussion: The reduced physical activity observed in the overweight adults may be related to their accumulation of adipose tissue at a rate about double their never-overweight counterparts, and this may be driving the higher rate of increase of CVD risk factors in the overweight groups.

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Ten-year changes in the obesity, abdominal adiposity, and serum lipoprotein cholesterol measures of Western Samoan men

Cited by 26 publications

References 47 publications

Serial Changes in Body Composition Throughout Adulthood and Their Relationships to Changes in Lipid and Lipoprotein Levels

Serial Changes in Body Composition Throughout Adulthood and Their Relationships to Changes in Lipid and Lipoprotein Levels

Non‐High‐Density Lipoprotein Cholesterol: An Alternate Target for Lipid‐Lowering Therapy

Lifetime Overweight Status in Relation to Serial Changes in Body Composition and Risk Factors for Cardiovascular Disease: The Fels Longitudinal Study

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