Ten-year analysis of adenovirus type 7 molecular epidemiology in Korea, 1995–2004: Implication of fiber diversity☆

Choi, Eun Hwa; Lee, Hoan Jong; Kim, Sun Jung; Eun, Byung Wook; Kim, Nam Hee; Lee, Jin A; Lee, Jun Ho; Song, Eun Kyung; Kim, Sohee

doi:10.1016/j.jcv.2006.01.001

Cited by 19 publications

(25 citation statements)

References 18 publications

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“…[12][13][14] Previous studies performed at our institute have focused on HAdV types 3 and 7. [15][16][17] However, there are few long-term data focusing on the change of severity over time and the association between clinically severe respiratory infections and HAdV types, like this.…”

Section: Discussionmentioning

confidence: 99%

Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991–2007)

Lee

Choi

Lee

2010

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 99%

Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991–2007)

Lee

Choi

Lee

2010

Journal of Clinical Virology

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“…Furthermore, a variety of genome types can be identified by the restriction fragment length polymorphism (RFLP) technique (6). Temporal and geographical distributions of serotypes and genome types have been reported (2,5,(7)(8)(9)(10)(11)(12). It has also been indicated that the emergence or switching of serotypes and genome types can cause HAdV outbreaks (8).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, global spread and switching or displacement of the predominant genome types has been reported (10,20,21). A nationwide outbreak in 1995 in Japan was caused by HAdV type d2, which could have been imported from another Asian country.…”

mentioning

confidence: 99%

Impact of Human Adenovirus Serotype 7 in Hospitalized Children with Severe Fatal Pneumonia in the Philippines

et al. 2014

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“…This novel receptor usage-based grouping system has been supported by studies from various groups (27,50,65,66). A newly emerged, pathogenic strain, Ad14-p1, uses the same receptor as prototype HAdV-B14 (89).HAdV-B3 and -B7 are considered to be widely distributed human pathogens (14,52,59). Studies from the United States show that HAdV-B3 and -B7 infections occur more often in adolescents and adults (23, 92), while studies from Europe and Asia indicate that these serotypes are also common in children (32,45,90).…”

mentioning

confidence: 99%

“…HAdV-B3 and -B7 are considered to be widely distributed human pathogens (14,52,59). Studies from the United States show that HAdV-B3 and -B7 infections occur more often in adolescents and adults (23,92), while studies from Europe and Asia indicate that these serotypes are also common in children (32,45,90).…”

mentioning

confidence: 99%

A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses

Wang

Beyer

Persson

et al. 2012

J Virol

105

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fWe have recently reported that a group of human adenoviruses (HAdVs) uses desmoglein 2 (DSG2) as a receptor for infection. Among these are the widely distributed serotypes HAdV-B3 and HAdV-B7, as well as a newly emerged strain derived from HAdV-B14. These serotypes do not infect rodent cells and could not up until now be studied in small-animal models. We therefore generated transgenic mice containing the human DSG2 locus. These mice expressed human DSG2 (hDSG2) at a level and in a pattern similar to those found for humans and nonhuman primates. As an initial application of hDSG2-transgenic mice, we used a green fluorescent protein (GFP)-expressing HAdV-B3 vector (Ad3-GFP) and studied GFP transgene expression by quantitative reverse transcription-PCR (qRT-PCR) and immunohistochemistry subsequent to intranasal and intravenous virus application. After intranasal application, we found efficient transduction of bronchial and alveolar epithelial cells in hDSG2-transgenic mice. Intravenous Ad3-GFP injection into hDSG2-transgenic mice resulted in hDSG2-dependent transduction of epithelial cells in the intestinal and colon mucosa. Our findings give an explanation for clinical symptoms associated with infection by DSG2-interacting HAdVs and provide a rationale for using Ad3-derived vectors in gene therapy. Human adenoviruses (HAdVs) have been classified into six species (HAdV-A to HAdV-F) currently containing 55 serotypes. Most adenovirus (Ad) serotypes utilize the coxsackie-adenovirus receptor (CAR) as a primary attachment receptor. However, this is not the case for species B Ad serotypes. Species B Ads form two genetic clusters, B1 (HAdV-B3, -B7, -B16, -B21, and -B50) and B2 (HAdV-B11p, -B14, -B34, and -B35) (84). Recently, we have suggested a new grouping of species B Ads based on their receptor usage (82). The members of group 1 (HAdV-B16, -B21, -B35, -B50) nearly exclusively utilize CD46 as a receptor; the members of group 2 (HAdV-B3, -B7, -B14) use a receptor that was unknown until recently (receptor X), group 3 (HAdV-B11p) preferentially interacts with CD46 but also utilizes receptor X if CD46 is blocked or absent. This novel receptor usage-based grouping system has been supported by studies from various groups (27,50,65,66). A newly emerged, pathogenic strain, Ad14-p1, uses the same receptor as prototype HAdV-B14 (89).HAdV-B3 and -B7 are considered to be widely distributed human pathogens (14,52,59). Studies from the United States show that HAdV-B3 and -B7 infections occur more often in adolescents and adults (23, 92), while studies from Europe and Asia indicate that these serotypes are also common in children (32,45,90). Since 2005, several outbreaks of HAdV-B14p1 in military facilities and civic communities have been reported in various countries, including the United States, Europe, and Asia (8,48,78). Ads, including HAdV-B3, enter the body via the mouth/nose and generally cause respiratory diseases. The respiratory tract epithelium is also the preferred site of viral replication. Subsequent virusinduced cyto...

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Ten-year analysis of adenovirus type 7 molecular epidemiology in Korea, 1995–2004: Implication of fiber diversity☆

Cited by 19 publications

References 18 publications

Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991–2007)

Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991–2007)

Impact of Human Adenovirus Serotype 7 in Hospitalized Children with Severe Fatal Pneumonia in the Philippines

A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses

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