Ten Emerging Trends in the Epidemiology of Diabetic Retinopathy

Sabanayagam, Charumathi; Yip, W. C. L.; Ting, Daniel; Tan, Gavin Siew Wei; Wong, Tien Yin

doi:10.1080/09286586.2016.1193618

Cited by 125 publications

(95 citation statements)

References 100 publications

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“…The search was constructed with the help of an Information Specialist. This search strategy was expanded by examining reference lists of all included articles, as well as published review articles of diabetes in New Zealand, and global review articles of DR and DM …”

Section: Methodsmentioning

confidence: 99%

“…This search strategy was expanded by examining reference lists of all included articles, as well as published review articles of diabetes in New Zealand, 7,16 and global review articles of DR and DM. [17][18][19] All citations obtained from the searches were imported into Endnote (Endnote X8, Thomson Reuters, San Francisco, California), and duplicates removed. The remaining records were imported into Microsoft Excel for screening.…”

Section: Information Sources and Search Strategymentioning

confidence: 99%

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Diabetic eye disease and screening attendance by ethnicity in New Zealand: A systematic review

Ramke

Jordan

Vincent

et al. 2019

Clinical Exper Ophthalmology

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To examine differences in incidence, prevalence and screening for diabetic retinopathy in New Zealand, we searched MEDLINE, EMBASE and CINAHL up to 6 December 2018 for observational studies reporting diabetic eye disease or attendance at retinal screening, disaggregated by ethnicity. Two authors separately screened and selected studies, and extracted data. None of the 11 included studies reported data on visual impairment from diabetic retinopathy. All nine studies reporting diabetic eye disease by ethnicity found Pacific people and Māori had higher rates of sight‐threatening disease and lower rates of screening attendance compared to Europeans. Data for Asian people were infrequently reported, but when they were, they also fared worse than Europeans. This review highlights that equity‐focused strategies are needed to address ethnic disparities in eye health among New Zealanders with diabetes. The review also identifies how research methods can be strengthened to enable future calculation of robust disease prevalence estimates.

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Section: Methodsmentioning

confidence: 99%

Section: Information Sources and Search Strategymentioning

confidence: 99%

Diabetic eye disease and screening attendance by ethnicity in New Zealand: A systematic review

Ramke

Jordan

Vincent

et al. 2019

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Of note, serum triglyceride levels were not considered in that study. As discussed in the review by Sabanayagam et al[93] 2016, changes in the circulating levels of lipids are not always associated with DR progression. A recent meta-analysis revealed that the triglycerides, total cholesterol and LDL cholesterol were signiﬁcantly elevated in persons with diabetic macular edema (DME) when compared to those with DM without DME[94].…”

Section: Dyslipidemia and Development Of Drmentioning

confidence: 99%

Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia

Mbata¹,

El-Magd²,

El-Remessy³

2017

WJD

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Diabetic retinopathy (DR) is the most feared ocular manifestation of diabetes. DR is characterized by progressive retinal damage that may eventually result in blindness. Clinically, this blindness is caused by progressive damage to the retinal microvasculature, which leads to ischemia, retinal swelling, and neovascularization. Retinopathy is associated with both type 1 and type 2 diabetes, with DR being the leading cause of new onset blindness in United States adults. Despite this strong association with diabetes, it must be noted that the development of retinopathy lesions is multifactorial and may occur in individuals without an established history of diabetes. Metabolic syndrome is a multifactorial condition of central obesity, hypertriglyceridemia, dyslipidemia, hypertension, fasting hyperglycemia, and insulin resistance. Although several studies examined the individual components observed in the metabolic syndrome in relation to the development of DR, there is conflicting data as to the association of the metabolic syndrome with the development of retinopathy lesions in non-diabetic subjects. This review will summarize the current literature on the evidence of the metabolic syndrome on retinopathy in subjects with and without an established history of diabetes. This review will also discuss some of the mechanisms through which metabolic syndrome can contribute to the development of retinopathy.

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“…28 Hyperglycemia has been designated as the most consistent risk factor for DR in type 1 diabetes mellitus. 29 Another point of concern is the management of DR in patients with clinical or sub-clinical cardiovascular disease. Treatment of DR is through laser ablation or use of anti-vascular endothelial growth factor (anti-VEGF) therapy for treating advanced stages of DR.…”

Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy and its’ association with carotid intima media thickness.

Bashir

Khan

Tanveer

2019

TPMJ

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ABSTRACT… Objectives: To evaluate the association of diabetic retinopathy (DR) and CIMT (carotid intima-media thickness) in diabetic subjects and to identify the factors contributing to retinopathy. Study Design: Comparative cross-sectional study. Setting: Creek General Hospital, United Medical and Dental College. Period: August 2017 to July 2018. Material and Methods: After identification of 62 subjects with type 2 diabetes mellitus for the study, their complete history, physical examination and relevant laboratory investigations were recorded. The diabetic retinopathy was assessed by ophthalmoscopy. All subjects underwent Doppler ultrasound scanning of the carotid arteries for measurement of CIMT (carotid intima-media thickness). The data was analyzed through SPSS version 20.0. Student's t-test was used to assess the association between retinopathy and CIMT and other continuous variables. The association of categorical variables was assessed by Chi-square. P-value of <0.05 was considered significant. Results: The target population constituted 29% males and 71% females. Among the participating subjects 50.2% had retinopathy while 49.8% subjects without retinopathy were included in the study. There was a strong association of retinopathy with carotid intimamedia thickness. Retinopathy was also associated with duration of diabetes mellitus, measures of glycemic control, serum creatinine levels, total cholesterol, LDL cholesterol, and serum triglycerides. Conclusion: Retinopathy is strongly associated with CIMT. Poor glycemic control, nephropathy, dyslipidemia and duration of diabetes also show association with retinopathy.

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Ten Emerging Trends in the Epidemiology of Diabetic Retinopathy

Abstract: The ten trends we observed in the current review may guide planning of public healthcare strategies for the management of DR and prevention of blindness.

Cited by 125 publications

References 100 publications

Diabetic eye disease and screening attendance by ethnicity in New Zealand: A systematic review

Diabetic eye disease and screening attendance by ethnicity in New Zealand: A systematic review

Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia

Diabetic retinopathy and its’ association with carotid intima media thickness.

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