Ten Cases of Feline Mesothelioma: an Immunohistochemical and Ultrastructural Study

Bacci, Barbara; Morandi, Federico; Meo, M. De; Marcato, Paolo Stefano

doi:10.1016/j.jcpa.2006.02.001

Cited by 36 publications

(57 citation statements)

References 21 publications

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“…Vimentin positivity in epithelial mesothelioma may be useful in distinguishing it from pulmonary adenocarcinoma, which is usually vimentin-negative. Similarly, the positivity of sarcomatous mesotheliomas for broad-spectrum pancytokeratin is useful in distinguishing this subtype from sarcomas, which are usually cytokeratine-negative (Attanoos et al, 2000;Bacci et al, 2006).…”

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confidence: 99%

“…The expression of both pancytokeratin and vimentin markers is a constant feature in mesotheliomas, attributable to the origin of mesothelial cells from the mesoderm, which can differentiate into both epithelial and mesenchymal cells (Mutsaers, 2004;Bacci et al, 2006). Calretinin, a calcium-binding protein expressed in feline neural tissues, is regarded as a reliable marker for mesothelioma in human oncology.…”

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confidence: 99%

“…Coexpression of vimentin and pancytokeratin, with a higher expression of the latter, confirmed the diagnosis. The negative expression of calretinin conflict with the diagnosis of mesothelioma; however, calretinin has proved negative in feline mesotheliomas (Bacci et al, 2006) and its reactivity not yet investigated in lions.…”

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Malignant pleural mesothelioma in a female Lion (Panthera leo)

Bollo

Scaglione

Tursi

et al. 2011

Research in Veterinary Science

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A B S T R A C TAn 18-year-old female lion (Panthera leo) was referred to the Department of Animal Pathology of the University of Turin (Italy). At necropsy, multiple nodular, 4-20-mm, confluent white firm nodules were scattered throughout the pleural surfaces of the thoracic wall and of the lungs. Histological lesions were represented by proliferations of papillary structures lined by cuboidal basophilic mesothelial cells with large, oval nuclei and abundant granular eosinophilic cytoplasm. Immunohistochemistry revealed immu-noreactivity for pancytokeratin and vimentin. None of the cells expressed calretinin antigen. Asbestos fibers and asbestos bodies were not detected respectively by light microscopy and by Scanning Electron Microscope-Energy Dispersive Spectrometer investigations. On the contrary, chrysotile asbestos were identified in samples from shelter material. Histological and immunohistochemical findings were consistent with the diagnosis of an epithelial malignant mesothelioma. To our best knowledge, this is the first report of a pleural mesothelioma in a lion.

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Malignant pleural mesothelioma in a female Lion (Panthera leo)

Bollo

Scaglione

Tursi

et al. 2011

Research in Veterinary Science

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“…In humans, about 80% of mesotheliomas are associated with inhalation of asbestos (Orenstein and Schenker 2000). In cats, spontaneous mesotheliomas are rare and predominantly malignant (Bacci et al 2006), with a few reports describing the tumours in the pericardium, pleura, and peritoneum (Piacenti et al 2004;Weiss et al 2010;Garret 2013).…”

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“…In a study of ten cats diagnosed with mesothelioma, eight of them had the neoplasia in the pleura and two, in the peritoneum. Histologically, they were classified as epithelioid (n = 5), fibrous (n = 3), and biphasic (n = 2) (Bacci et al 2006).…”

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Biphasic pericardial and pleural mesothelioma in a cat: a case report

Filho¹,

Magalhães²,

Conforti³

et al. 2015

Vet. Med.

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ABSTRACT:An 11-year-old castrated male Persian cat was admitted to the veterinary clinic showing signs of lethargy, lack of appetite, laboured breathing, dyspnoea, and cyanosis. The echocardiogram showed a large amount of pleural effusion, fibrin, and a mass measuring 1.89 cm in diameter adhered to the parietal pericardium. Upon necropsy, several nodules were observed on the pericardium sac and pleura. Histological evaluation of the nodules and mediastinal lymph node revealed the presence of neoplastic cells of epithelial and mesenchymal origin. Immunolabelling was positive for both cytokeratin AE1/AE3 and vimentin in the primary tumour and in the mediastinal lymph node. In the present report, immunohistochemical analysis supported the diagnosis that had been obtained based on clinical signs, histopathological examination, and echocardiogram.

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