Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice

Yamaguchi, Hiroyuki; Kitami, Megumi; Koecklin, Karin Harumi Uchima; He, Li; Wang, Jianbo; Lagor, William R.; Perrien, Daniel S.; Komatsu, Yoshihiro

doi:10.1016/j.ydbio.2021.12.004

Cited by 10 publications

(4 citation statements)

References 56 publications

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“…The CFAP43 gene is closely associated with cilia [ 29 ], and cilia affect body traits in both osteogenesis and energy metabolism. The absence of cilia can lead to shortened limbs [ 30 ] and disturbed lipid metabolism [ 31 ] and affect body homeostasis [ 32 ]. In addition, cilia on the cell surface are closely associated with the movement of certain cells.…”

Section: Discussionmentioning

confidence: 99%

Relationships between the Mini-InDel Variants within the Goat CFAP43 Gene and Body Traits

Wang

et al. 2022

Animals

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The cilia- and flagella-associated protein 43 (CFAP43) gene encodes a member of the cilia- and flagellum-associated protein family. Cilia on the cell surface influence intercellular signaling and are involved in biological processes such as osteogenesis and energy metabolism in animals. Previous studies have shown that insertion/deletion (InDel) variants in the CFAP43 gene affect litter size in Shaanbei white cashmere (SBWC) goats, and that litter size and body traits are correlated in this breed. Therefore, we hypothesized that there is a significant relationship between InDel variants within the CFAP43 gene and body traits in SBWC goats. Herein, we first investigated the association between three InDel variant loci (L-13, L-16, and L-19 loci) within CFAP43 and body traits in SBWC goats (n = 1827). Analyses revealed that the L-13, L-16, and L-19 loci were significantly associated with chest depth, four body traits, and three body traits, respectively. The results of this study are in good agreement with those previously reported and could provide useful molecular markers for the selection and breeding of goats for body traits.

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Section: Discussionmentioning

confidence: 99%

Relationships between the Mini-InDel Variants within the Goat CFAP43 Gene and Body Traits

Wang

et al. 2022

Animals

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“…However, based on its cellular functions [ 34 ], IFT20 defects may also be associated with different system-related diseases including those affecting the cardiovascular, immune, nervous, reproductive, and respiratory systems. Furthermore, IFT20 may be implicated in the modulation of signaling and cell differentiation of different cell types in addition to those previously described, which include T lymphocytes [ 37 , 53 , 62 , 65 ], proepicardium and myocardium cells [ 72 ], chondrocytes [ 96 ] and osteoblasts [ 83 , 89 ]. Interestingly, it has been recently reported that IFT20 is a critical regulator of bone marrow mesenchymal stem cell (MSC) lineage commitment at an early stage [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport

Finetti

Onnis²,

Baldari³

2022

IJMS

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Initially discovered as the smallest component of the intraflagellar transport (IFT) system, the IFT20 protein has been found to be implicated in several unconventional mechanisms beyond its essential role in the assembly and maintenance of the primary cilium. IFT20 is now considered a key player not only in ciliogenesis but also in vesicular trafficking of membrane receptors and signaling proteins. Moreover, its ability to associate with a wide array of interacting partners in a cell-type specific manner has expanded the function of IFT20 to the regulation of intracellular degradative and secretory pathways. In this review, we will present an overview of the multifaceted role of IFT20 in both ciliated and non-ciliated cells.

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“…Research has demonstrated that deficiencies in IFT20, IFT52, IFT80, and IFT88 during mouse limb development can result in skeletal abnormalities (Kitami et al, 2019;Chinipardaz et al, 2022;Guleria et al, 2022;Yamaguchi et al, 2022;Chen and He, 2023). Moreover, mutations in IFT25, IFT27 interfere with the Hedgehog signaling pathway (Keady et al, 2012;Eguether et al, 2014;Yang et al, 2015;Ge et al, 2021), while silencing of IFT80 diminishes Hedgehog signaling but enhances Wnt signaling, underscoring the ability of primary cilia to modulate Hedgehog and Wnt signaling for the regulation of cartilage development (Yang and Wang, 2012;Wang et al, 2013).…”

Section: Structure and Function Of Primary Ciliamentioning

confidence: 99%

Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

Long,

Chen,

Xiao

et al. 2024

Front. Cell Dev. Biol.

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Primary cilia, serving as the central hub for cellular signal transduction, possess the remarkable ability to translate diverse extracellular signals, both chemical and mechanical, into intracellular responses. Their ubiquitous presence in the reproductive system underscores their pivotal roles in various cellular processes including development, differentiation, and migration. Emerging evidence suggests primary cilia as key players in reproductive physiology and associated pathologies. Notably, primary cilia have been identified in granulosa cells within mouse ovaries and uterine stromal cells, and perturbations in their structure and function have been implicated in a spectrum of reproductive dysfunctions and ciliary-related diseases. Furthermore, disruptions in primary cilia-mediated signal transduction pathways under pathological conditions exacerbate the onset and progression of reproductive disorders. This review provides a comprehensive overview of current research progress on primary cilia and their associated signaling pathways in reproductive physiology and diseases, with the aim of furnishing theoretical groundwork for the prevention and management of primary cilia-related structural and functional abnormalities contributing to reproductive system pathologies.

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Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice

Cited by 10 publications

References 56 publications

Relationships between the Mini-InDel Variants within the Goat CFAP43 Gene and Body Traits

Relationships between the Mini-InDel Variants within the Goat CFAP43 Gene and Body Traits

IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport

Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

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