Temporomandibular joint innervation: Anatomical study and clinical implications

Demiryürek, Mehmet; Vargel, İbrahim

doi:10.1016/j.aanat.2021.151882

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Nonetheless, we observed mrgprD + and trpV1 + fibers together with NFH + ones in LPM, while mrgprD + /NFH - and trpV1 + /NFH - nerves were absent in LPM. This phenomenon could be explained by the fact that LPM is innervated by a mandibular nerve branch - ATN, which travels through LPM on the way to innervating TMJ ligaments (Kucukguven et al, 2022). Therefore trpV1, mrgprD and NFH could belong to such a nerve trunk targeting TMJ.…”

Section: Discussionmentioning

confidence: 99%

“…Increased responsiveness of sensory neurons during TMD-M could occur in any muscle controlling temporomandibular joint (TMJ) articulation, including superficial and in the deep heads of masseter muscle (MM), temporal muscle (TM), medial pterygoid closing muscles (MPM) as well as gliding superior and inferior heads of the lateral pterygoid muscles (LPM) (Kucukguven et al, 2022; Nickel et al, 2022) ( Fig 1 ). Muscle tissues of the TMJ structure are innervated by the masseteric nerve (MN) for MM, the auriculotemporal nerve (ATN) for LPM, and temporal nerve (TN) for TM ( Fig 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets

Hovhannisyan

Lindquist

Belugin

et al. 2023

Preprint

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Myogenous temporomandibular disorders (TMD-M) are the most prevalent group of painful orofacial conditions, and the second most frequent among musculoskeletal pain conditions. TMD-M is associated with an increased responsiveness of nerves innervating the masseter (MM), temporal (TM), medial pterygoid closing (MPM) and lateral pterygoid gliding muscles (LPM). Treatment of this disorder remains difficult and is further complicated by each muscle having diverse and functionally distinct nerve innervation. This study examined expression of sensory markers in MM, TM and LPM of adult male common marmosets, a type of non-human primate. Using immunohistochemistry, we found that masticatory muscles were predominantly innervated with A-fibers (NFH+). All C-fibers (pgp9.5+/NFH-) observed in masticatory muscles were peptidergic (CGRP+) and lacked antibody labeling for mrgprD, trpV1 and the silent nociceptive marker, CHRNA3. The proportion of C- to A-fibers was highest in LPM, while MM had a minimal percentage (6-8%) of C-fibers. Interestingly, C-fibers in masticatory muscle may have myelin sheath, since many NFH- nerves were labeled with GFAP+. A-fiber types were also dissimilar among these muscles. Thus, there are substantially more peptidergic A-fibers (CGRP+/NFH+) in TM and LPM compared to MM. Almost all A-fibers in MM expressed trkC, with some of them having trkB and parvalbumin (PV). In contrast, a lesser number of TM and LPM nerves expressed trkC, lacked trkB and had fewer PV+ fibers in LPM. Along with sensory fibers, the masticatory muscles contain sympathetic fibers (tyrosine hydroxylase; TH+), which are located around blood vessels. This TH expression was absent in trigeminal neurons. Overall, the masticatory muscles of male marmosets have distinct expression patterns when compared to each muscle of the jaw and cutaneous fibers innervated by DRG neurons.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets

Hovhannisyan

Lindquist

Belugin

et al. 2023

Preprint

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“…The mandibular nerve features nine branches, but only three innervate aspects of the TMJ: the masseteric, deep temporal, and auriculotemporal nerves. The masseteric nerve innervates deep aspects of the masseter, the deep temporal nerve innervates the temporalis and masseter ( 7 ), and the auriculotemporal nerve innervates the joint capsule and the retrodiscal tissue ( 8 ).…”

Section: The Anatomy Of the Temporomandibular Jointmentioning

confidence: 99%

Trigeminal somatosensation in the temporomandibular joint and associated disorders

Perry,

Emrick

2024

Front. Pain Res.

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The temporomandibular joint (TMJ) consists of bone, cartilage, ligaments, and associated masticatory muscles and tendons that coordinate to enable mastication in mammals. The TMJ is innervated by the trigeminal nerve (CNV), containing axons of motor and somatosensory neurons. Somatosensation includes touch, temperature, proprioception, and pain that enables mammals to recognize and react to stimuli for survival. The somatosensory innervation of the TMJ remains poorly defined. Disorders of the TMJ (TMD) are of diverse etiology and presentation. Some known symptoms associated with TMD include facial, shoulder, or neck pain, jaw popping or clicking, headaches, toothaches, and tinnitus. Acute or chronic pain in TMD stems from the activation of somatosensory nociceptors. Treatment of TMD may involve over- the-counter and prescription medication, nonsurgical treatments, and surgical treatments. In many cases, treatment achieves only a temporary relief of symptoms including pain. We suggest that defining the sensory innervation of the temporomandibular joint and its associated tissues with a specific focus on the contribution of peripheral innervation to the development of chronic pain could provide insights into the origins of joint pain and facilitate the development of improved analgesics and treatments for TMD.

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“…The TMJ has several proprioceptive receptors, particularly in the parenchyma of the articular disc: Golgi-Mazzoni and Ruffini; Myelinated and unmyelinated nerve fibers are innervated primarily by the auriculotemporal nerve posteriorly, the masseteric nerve anteriorly, the posterior deep temporal nerve anteromedially, and the branch of the TMJ arising directly from the mandibular nerve anteriorly. The middle part, although there are variations in these innervation pathways [13].…”

Section: Innervationmentioning

confidence: 99%

Biomechanics of the Temporomandibular Joint

Andrés¹,

Emilio²,

James³

2023

Temporomandibular Joint - Surgical Reconstruction and Managements

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Biomechanics is the study of mechanics applied to living beings, it analyzes loads, stress, tension, movement, size, shape, and structure of the body. The temporomandibular joint in physiological states is subject to the interaction of various bone (jaw and temporal), nervous, cartilaginous, and muscular components. When there is an alteration in any of the components, normal biomechanics are affected. Knowing in detail how each element works individually and is essential for the diagnosis and treatment of the different pathologies of the temporomandibular joint. The reconstructive procedures must carefully assess all these factors to achieve long-term success. The purpose of this chapter is to analyze the temporomandibular joint encompassing anatomy, physiology with a biomechanical approach for its diagnosis and treatment.

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Temporomandibular joint innervation: Anatomical study and clinical implications

Cited by 11 publications

References 29 publications

Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets

Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets

Trigeminal somatosensation in the temporomandibular joint and associated disorders

Biomechanics of the Temporomandibular Joint

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