“…Peripheral nerves are the inter-and intra-neural circuit interface, allowing interaction with different neural circuits, organ systems, and the external world. Blocking undesired hyperactivity through peripheral nerves can be a useful therapeutic approach for alleviating disease symptoms such as pain and hyperactive motor reflexes observed in spinal cord injuries [17], multiple sclerosis [18], and cerebral palsy [19], as well as hyperactivity in autonomic circuits implicated in the development or progression of cardiac, inflammatory, and metabolic diseases [20,21]. Various methods exist for blocking conduction of neural activity including application of pressure, temperature, and pharmacological agents.…”