Temporary vascular occlusion with poloxamer 407

Raymond, Jean; Metcalfe, Annick; Salazkin, Igor; Schwarz, Alexander

doi:10.1016/j.biomaterials.2003.10.085

Cited by 78 publications

(62 citation statements)

References 11 publications

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“…However, this effect is likely to be insignificant because Poloxamer 407 has been used as a temporary vascular occlusion agent (20). Although small fragments of clots may detach and escape from the occluded vessels, especially the large veins (i.e., iliac veins and vena cava), they will accumulate in the lungs and be rapidly dissolved there (20). The rate of dissolution is much faster than that of large clots formed in the lung after a direct injection into the pulmonary artery because the rate of dissolution decreases with increasing size of clots.…”

Section: Resultsmentioning

confidence: 99%

A Novel Method for Viral Gene Delivery in Solid Tumors

Wang¹,

Liu

et al. 2005

Cancer Research

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Intratumoral infusion is the most commonly used method for viral gene delivery in clinical trials for cancer treatment. However, a potential problem in this approach is that viral vectors may disseminate from tumor to normal tissues during and after the infusion. To reduce the dissemination, we developed a novel method based on a biocompatible polymer, poloxamer 407, which could significantly increase the viscosity of virus suspension when the temperature was changed from 4°C to 37°C. With this method, we could significantly increase transgene expression in solid tumors and reduce virus dissemination by 2 orders of magnitude after intratumoral infusion of adenoviral vectors. The mechanism of reduction was likely to be that the viscous poloxamer solution blocked convection of viral vectors in the interstitial space and the lumen of microvessels in the vicinity of the infusion site. This method has a potential to be used in the clinic for enhancing efficacy and reducing toxicity in viral gene therapy. (Cancer Res 2005; 65(17): 7541-5)

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Section: Resultsmentioning

confidence: 99%

A Novel Method for Viral Gene Delivery in Solid Tumors

Wang¹,

Liu

et al. 2005

Cancer Research

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“…As thermoreversibility allows PIB to be redissolved when the temperature falls, nontargeted embolization of PIB could be solved via redissolution, 30 and PIB might also be used for temporary embolization. 11 Because PNIPAM-based polymers have been shown to serve as vectors for drugs, proteins, and target genes, [6][7][8] PIB could also be modified to a "bioactive embolic agent" and thus widely applied in endovascular therapy.…”

Section: Inflammation Reactionsmentioning

confidence: 99%

“…10 Poloxamer, which has rapid reversible sol-gel transition behavior with a change of temperature, was reported as a temporary embolic material several years later. 11 Recently, a linear PNIPAM has been investigated in embolization of AVMs.…”

mentioning

confidence: 99%

Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Zhao¹,

Zheng²,

Gao³

et al. 2012

AJNR Am J Neuroradiol

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“…Which seems indicates one of the important mechanisms of theophylline for its lipid lowering action. Poloxamer 407 is a hydrophilic, non-toxic, surface active agent with a low degree of toxicity that is being adapted for more specialized applications such as sealing permeabilized cell membranes and vascular occlusion procedures [5][6][7][8][9][10] . It has been shown to cause significant elevations in serum cholesterol and triglyceride levels after a single injection in rodent models 11 .…”

Section: Effect Of Theophylline On Biochemical Parameters In Poloxamementioning

confidence: 99%

Study of Theophylline Against Experimentally Induced Hyperlipidemia

Parmar¹,

Jain²,

Pharm³

2014

J Pharm Sci Innov

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The present study was planned to evaluate the anti-hyperlipidemic activity of theophyllin, a bronchodilator for its effect on lipid levels, HMG-CoA reductase activity and lipid peroxidation in Poloxamer 407 and high-cholesterol diet-induced hyperlipidemia in rats. The animals were divided into four groups, viz. normal, high cholesterol diet (control), Atorvastatin and theophylline treated groups. In Poloxamer-407 induced acute hyperlipidemia model, blood samples were collected at 15 and 24 hour period, and there after lipid parameters and HMG-CoA reductase activity were estimated and compared with atorvastatin reference standard treated animals. In high fat diet-induced model, animals were given respective treatment for a period of twenty one days. Lipid parameters and antioxidant parameters were measured and compared with atorvastatin treated animals at the end of study period. High cholesterol diet and Poloxamer 407 caused a significant increase in serum total cholesterol (TC), LDL-C, VLDL-C, TG and atherogenic index (AI) along with significant decrease in HDL-C and HDL/LDL ratio. In poloxamer model, Theophylline pre-treatment showed a significant decrease in total cholesterol, LDL-C, VLDL-C, and atherogenic index, with no marked change in HDL-C, TG and HDL/LDL ratio. It also showed significant inhibition of HMG-CoA reductase activity as compared to poloxamer control group. Similarly, in high fat diet model, theophylline demonstrated significant reduction in serum cholesterol, TG, VLDL and AI. In addition this, antioxidant parameters were measured in terms of Malondealdehyde levels, superoxide dismutase, catalase and reduced glutathione. Theophylline did not show any remarkable change in this parameter suggesting lack of antioxidant mechanisms. Based on our data, it is suggested that theophylline possesses hypolipidemic activity. The mechanism of action of this could be attributed to reduction (p < 0.05) in an AI and inhibition of HMG-CoA reductase activity.

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Temporary vascular occlusion with poloxamer 407

Cited by 78 publications

References 11 publications

A Novel Method for Viral Gene Delivery in Solid Tumors

A Novel Method for Viral Gene Delivery in Solid Tumors

Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Study of Theophylline Against Experimentally Induced Hyperlipidemia

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