Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial

Erbel, Raimund; Mario, Carlo Di; Bartúnek, Jozef; Bonnier, J. J. R. M.; Bruyne, Bernard De; Eberli, Franz R.; Erné, Paul; Haude, Michael; Heublein, B; Horrigan, M.; Ilsley, Charles; Böse, Dirk; Koolen, Jacques; Lüscher, Thomas F.; Weissman, Neil J.; Waksman, Ron

doi:10.1016/s0140-6736(07)60853-8

Cited by 802 publications

(454 citation statements)

References 32 publications

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“…Agha et al [71] found that the addition of MgSO 4 had a minimal influence on the biocorrosion of HP-Mg in a HBSS. As SO 4 2− has been found to slightly increase the dissolution of Mg previously [59,67], it is reasonable to assume that Mg 2+ was slightly retarding the corrosion in this case, countering the effect of the addition of SO 4 2− . These results suggest that, when a solution is devoid of Mg 2+ , the addition of these ions has a moderate to substantial influence on decreasing the corrosion rates.…”

Section: Magnesium Ions (Mg 2+ )mentioning

confidence: 80%

“…Their incorporation into the corrosion product layers to form (Mg, Ca)-P influences the corrosion mechanism of the Mg alloys and as such, their inclusion in SBFs is essential for an accurate biocorrosion assessment. 4 2− ) Xin et al [59] and Ma et al [67] found that SO 4 2− had slight effect in promoting the dissolution of Mg. Moreover, these effects appear to be much less than those of other anions.…”

Section: Phosphate Ions (H 2 Pomentioning

confidence: 98%

“…These are different to traditional metallic biomaterials, which are dominated by corrosion resistant metals such as titanium, cobalt-chromium alloys and stainless steel [2]. The key application for biodegradable metals is for temporary medical implants and devices [3][4][5][6][7]. Biodegradable metals corrode and disappear after implantation.…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Section: Magnesium Ions (Mg 2+ )mentioning

confidence: 80%

Section: Phosphate Ions (H 2 Pomentioning

confidence: 98%

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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“…In this respect, bioresorbable polymers represent promising substitutes for metallic stents. The first developments of biodegradable stents/scaffolds (BDS) include the paclitaxel-eluting poly (L-lactic acid) (PLLA) Aachen stent [5], the Igaki-Tamai stent [6], a resorbable Magnesium stent [7], and a polylactide-based stent [8]. The Igaki-Tamai stent was the first fully degradable stent ever implanted in humans.…”

Section: Introductionmentioning

confidence: 99%

Trend to move from permanent metals to degradable, multifunctional polymer or metallic implants in the example of coronary stents

Reinthaler

Jung

Landmesser

et al. 2016

Expert Review of Medical Devices

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“…The AMS-1 (Biotronik, Berlin, Germany) was the first metallic, magnesium biodegradable stent. Clinical trial (PROGRESS AMS) revealed rapid degradation, high rate of TLR (45 %) and 42 % reduction in the lumen area at 12 months [4]. These observations led to modifications in the design and drug release profile (AMS-2 and AMS-3 stents), new clinical program is currently continued.…”

Section: Introductionmentioning

confidence: 99%

Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants

et al. 2012

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The biggest challenge in the treatment of arterial stenosis remains the issue of optimization of stent design. Despite continuous improvement in surgical techniques and use of intensive pharmacotherapy, the results of stent coronary interventions may be unsatisfactory, and long-term interaction of a metal implant with a blood vessel results in complications such as recurrent stenosis and thrombosis. Therefore, it is necessary to search for new materials and stent designs to obtain a stent capable of restoring flow in the vessel and disappearing after fulfilling its function. Such stent must also be compatible with the vessel wall to enable regeneration of new structure of endothelium and deeper artery layers damaged during implantation. Consequently, there is ongoing search for functional solutions with minimum effects of long-term implant-tissue interaction. In light of the above, the team investigated the possibility of using biodegradable polymers already mentioned in the literature as a construction material for vascular stent. The study used three polyhydroxyacids based on lactic acid and glycolic acid: poly(l-lactide), poly(lactideco-glycolide) and poly(d,l-lactide-co-glycolide). The research focused on assessing changes in mechanical, thermomechanical, rheological, and fatigue properties during the process of hydrolytic degradation. The analysis also covered the rate of release of degradation products. The results of the conducted tests indicate the possibility of developing a vascular stent with biodegradable polymers.

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Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial

Cited by 802 publications

References 32 publications

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Trend to move from permanent metals to degradable, multifunctional polymer or metallic implants in the example of coronary stents

Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants

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