Temporary pacing in children

Batra, Anjan S.; Zeltser, Ilana

doi:10.1002/9781119333050.ch12

Cited by 2 publications

(1 citation statement)

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“…Most importantly, the stability of the biointerfaces was demonstrated by the negligible changes in electrochemical measurements over a period roughly equal to 2 months at body temperature, which is comparable to the clinical duration of temporary cardiac sensing and pacing (i.e., from hours/days to weeks/months) used for reversible heart block treatment, pediatric patients as a bridge to permanent pacemakers, or rhythm management during the antibiotic therapy in patients currently suffering from device‐induced infections. [ 62–65 ]…”

Section: Discussionmentioning

confidence: 99%

Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment

et al. 2023

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Heart rhythm disorders, known as arrhythmias, cause signi cant morbidity and are one of the leading causes of mortality. Cardiac arrhythmias are primarily treated by implantable devices, such as pacemakers and de brillators, or by ablation therapy guided by electroanatomical mapping.Pharmacological treatments are mostly ineffective. Both implantable and ablation therapies require sophisticated biointerfaces for electrophysiological measurements of electrograms and delivery of therapeutic stimulation or ablation energy. In this work, we report for the rst time on graphene biointerface for in vivo cardiac electrophysiology. Leveraging sub-micrometer thick tissue-conformable graphene arrays, we demonstrate sensing and stimulation of the open mammalian heart both in vitro and in vivo. Furthermore, we demonstrate graphene pacemaker treatment of a pharmacologically-induced arrhythmia, AV block. The arrays show effective electrochemical properties, namely interface impedance down to 40 Ohm×cm 2 , charge storage capacity up to 63.7 mC/cm 2 , and charge injection capacity up to 704 µC/cm 2 . Transparency of the graphene structures allows for simultaneous optical mapping of cardiac action potentials and calcium transients while performing electrical measurements and stimulation. Our report presents evidence of the signi cant potential of graphene biointerfaces for the future clinical device-and catheter-based cardiac arrhythmias therapies.

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Section: Discussionmentioning

confidence: 99%