Temporary kidney dysfunction: supplementation with Meriva® in initial, transient kidney micro-macro albuminuria

Ledda, Andrea; Belcaro, Gianni; Feragalli, Beatrice; Hosoi, Morio; Cacchio, Marisa; Luzzi, R; Dugall, Mark; Cotellese, Roberto

doi:10.23736/s0031-0808.18.03575-9

Cited by 13 publications

(17 citation statements)

References 17 publications

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“…In comparison with the control group, albuminuria improved within four weeks, and fatigue has significantly decreased or disappeared. 25 Although these studies indicate the effect of curcumin on the treatment of chronic fatigue syndrome, this supplement did not have a significant effect on the fatigue severity of PD patients in the present study. This difference in outcome may explain by differences in the type of study design and type of diseases.…”

Section: Discussioncontrasting

confidence: 64%

Effect of Nanomicelle Curcumin on Quality of Life and Sleep in Patients With Parkinson’s Disease: A Double-Blind, Randomized, and PlaceboControlled Trial

Maghbooli

Safarnejad

Mostafavi

et al. 2019

Int Clin Neurosci J

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Background: Considering the evidence indicating the neuronal protective effects of curcumin in previous studies, this double-blind, randomized, placebo-controlled, and parallel-group trial was aimed at exploring the possible nanomicelle curcumin (SinaCurcumin®, nano-micellar soft gel)- mediated impact on sleep, fatigue, and quality of life (QoL) in patients with Parkinson’s disease (PD). Methods: A sample of 50 PD patients were recruited and randomly divided into experimental (25) and control groups (25). Sleep quality, fatigue, and QoL were assessed based on the Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), and the Parkinson’s Disease Questionnaire–39 (PDQ-39), respectively, at the beginning and the end of the study. The groups were treated for three months by 80 mg of nano-micellar soft gel twice a day. Results: Nanomicelle curcumin significantly increased sleep quality and QoL compared with placebo (P values=0.0001 and 0.0002, respectively) in PD patients. This significant difference has not influenced by the duration of the disease, the severity of disease progression (Hoehn & Yahr scale), and the cumulative dose of levodopa. This supplement did not have a significant effect on the fatigue severity of patients compared to placebo. Conclusion: It has proposed that the nanomicelle curcumin can be used to improve sleep quality and QoL in PD patients.

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Section: Discussioncontrasting

confidence: 64%

Effect of Nanomicelle Curcumin on Quality of Life and Sleep in Patients With Parkinson’s Disease: A Double-Blind, Randomized, and PlaceboControlled Trial

Maghbooli

Safarnejad

Mostafavi

et al. 2019

Int Clin Neurosci J

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“…In the majority of the low‐dose studies assessing curcumin formulated specifically to enhance bioavailability, the major conjugate metabolites were similarly not assessed, and detection of parent curcuminoids was undertaken only via hydrolysis of plasma curcumin conjugates. Summaries for a selection of low‐dose studies are shown in Table S3, Supporting Information …”

Section: Resultsmentioning

confidence: 99%

Detection of Plasma Curcuminoids from Dietary Intake of Turmeric‐Containing Food in Human Volunteers

Mahale

Singh

Howells

et al. 2018

Molecular Nutrition Food Res

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“…By barring NF-κ Bcurcumin restricts the retrograde response which in turn leads to prohibition of sepsis stimulated muscle wasting (Alamdari et al, 2009). In aged healthy population, curcumin obviated muscle loss, better physical capabilities as well as deferred the initiation of sarcopenia (Ledda et al, 2019). Curcumin can be utilized to manage fatigue like signs in COVID-19 as per these findings.…”

Section: Antifatigue Effectmentioning

confidence: 99%

Potential Role of Curcumin as a Treatment Option for Covid-19: A Review

Hussain¹

2021

PLANT ARCHIVES

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Severe Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes CoV disease 2019 (COVID-19) which is presently a pandemic declared by world health organization. Treatment modalities for this disease are being explored. Curcumin the phytoconstituent of Curcuma longa, can be a potential treatment for COVID-19 because various findings suggest its therapeutic properties like antioxidant, antiemetic, antifatigue effects which can potentially manage symptoms and signs of COVID-19, also it has antiviral properties such as impeding the viral binding to host cell as well as replication. It has restrictive actions on viral protease as well and having inhibitory actions on pro-inflammatory cytokine molecules.Thus, it alleviates symptoms due to inflammation such as fibrosis and edema in pulmonary region. Broncho dilatory effects of curcumin as well as suppression of cough via acting on bradykinin thus curcumin can alleviate symptoms such as cough in COVID-19 sufferers. Curcumin also has preventive actionson Cardiovascular and renal damage due to COVID-19. All these potential activities suggest the possible use of curcumin in management of COVID-19. Clinical studies should be considered to explore the same. In this review we highlight the potential therapeutic effects of curcumin against COVID-19.

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Temporary kidney dysfunction: supplementation with Meriva® in initial, transient kidney micro-macro albuminuria

Cited by 13 publications

References 17 publications

Effect of Nanomicelle Curcumin on Quality of Life and Sleep in Patients With Parkinson’s Disease: A Double-Blind, Randomized, and PlaceboControlled Trial

Effect of Nanomicelle Curcumin on Quality of Life and Sleep in Patients With Parkinson’s Disease: A Double-Blind, Randomized, and PlaceboControlled Trial

Detection of Plasma Curcuminoids from Dietary Intake of Turmeric‐Containing Food in Human Volunteers

Potential Role of Curcumin as a Treatment Option for Covid-19: A Review

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