Temporary decrease in cardiac parasympathetic tone after acute myocardial infarction

Rothschild, Marylee; Rothschild, Armand; Pfeifer, Michael

doi:10.1016/0002-9149(88)90670-4

Cited by 53 publications

(22 citation statements)

References 6 publications

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“…However, it must be remembered that autonomic neuropathy cannot be diagnosed on the basis of one abnormal cardiovascular reflex. Furthermore, myocardial infarction is associated with autonomic dysfunction (35)(36)(37)(38), which may cause similar alterations in Valsalva ratio as diabetic autonomic neuropathy (35). Therefore, in a critical interpretation the findings described by Niakan et al may only reflect the often disregarded effect of myocardial infarction on autonomic nervous function.…”

Section: Diabetic Autonomic Neuropathy and Silentmentioning

confidence: 99%

“…One limitation on any clinical evaluation of the association of autonomic neuropathy with the lack of cardiac pain is that this part of autonomic function is difficult to assess. The heartrate responses used for the conventional diagnosis of autonomic neuropathy mainly reflect the integrity of cardiac parasympathetic activity, and an additional problem with the heart-rate tests is the confounding effect of coronary artery disease and myocardial infarction (35)(36)(37)(38)40,41). Preliminary studies suggest that the distribution of myocardial sympathetic nerves may be assessed with radiolabeled metaiodobenzylguanidine (43).…”

Section: Diabetic Autonomic Neuropathy and Silentmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Silent Coronary Artery Disease, Diabetes, and Autonomic Neuropathy: Fact or Fallacy?

Airaksinen

Koistinen

1992

Diabetes Care

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Section: Diabetic Autonomic Neuropathy and Silentmentioning

confidence: 99%

Section: Diabetic Autonomic Neuropathy and Silentmentioning

confidence: 99%

Association Between Silent Coronary Artery Disease, Diabetes, and Autonomic Neuropathy: Fact or Fallacy?

Airaksinen

Koistinen

1992

Diabetes Care

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“…Cardiac patients are often afflicted by an impairment of their autonomic nervous system (ANS), which is characterized either by an increase in sympathetic function, a decrease in parasympathetic function, or both (Thayer et al, 2010). Impaired ANS function has been linked to several types of CVDs, including coronary artery disease, ischemic heart disease, and heart failure (Musialik-Lydka et al, 2003;Rothschild et al, 1988;Schroeder et al, 2003;Wennerblom et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Investigating the autonomic nervous system and cognitive functions as potential mediators of an association between cardiovascular disease and driving performance

Gaudet

Bélanger²,

Corriveau

et al. 2013

Can. J. Physiol. Pharmacol.

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Cardiovascular disease (CVD) impacts the autonomic nervous system and cognitive functions related to activities of daily living, including driving an automobile. Although CVD has been linked to unsafe driving, mechanisms underlying this relationship remain elusive. The aim of this study was to examine the role of cognitive functions and the autonomic nervous system as potential mediators of driving performance. Nineteen individuals having recently suffered a cardiac event and sixteen individuals with no history of CVD completed a simulated drive using a STISIM simulator to assess driving performance. Heart rate was recorded throughout testing using a Polar RS800CX heart rate monitor and measures of executive, orienting and alerting functions were obtained through the Attention Network Test. We used the Baron and Kenny analysis method to assess potential mediating effects of the relationship between CVD and driving performance. Executive function was the only potential mediator investigated to be associated with driving (p < 0.01) and CVD (p < 0.05), however, it did not appear to play a mediating role (p = 0.28). These results suggest that individuals with CVD exhibit decrements in complex cognitive tasks such as driving and that further research is needed to better understand the mechanisms underlying this relationship.

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“…Changes in the autonomic balance of the heart, in particular subnormal vagal activity and sympathetic hyperactivity, have been reported after ST-elevation myocardial infarction (STEMI) [1, 2]. It is currently widely believed that this autonomic imbalance is not merely a consequence of the infarct but actively and deleteriously influences the clinical course of the disease by increasing electrical instability of the myocardium, platelet aggregability and wall stress in addition to vasoconstriction of coronary arteries [3].…”

Section: Introductionmentioning

confidence: 99%

Ultra-Short-Term Heart Rate Variability for Early Risk Stratification following Acute ST-Elevation Myocardial Infarction

et al. 2009

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Objectives: To evaluate the prognostic significance of early ultra-short-term heart rate variability (HRV) measurement in patients admitted for ST-elevation myocardial infarction (STEMI). Methods: HRV was calculated retrospectively from the standard admission and discharge 10-second ECG of 196 consecutive patients with STEMI. Reduced HRV was defined as standard deviation of N-N intervals (SDNN) <9.5 (25th percentile). Data regarding all end points were obtained 2 years after discharge for all patients. Results: Patients’ age was 60.9 ± 13 years and 21% were female. Admission SDNN was lower than discharge SDNN (20.2 ± 18 vs. 34.2 ± 31.1, respectively; p = 0.001). Admission and discharge SDNN positively correlated with survival (r = 0.16, p = 0.03 and r = 0.15, p = 0.04, respectively), but were not predictive of other cardiovascular end points. Reduced admission SDNN was associated with increased mortality at 1 and 6 months, and 1 and 2 years after admission, while discharge SDNN was associated only with 1- and 2-year mortality. Using multivariate analysis, adjusted for potential confounders, admission SDNN <9.5 was found to be an independent risk factor for 2-year mortality (odds ratio = 2.9, 95% confidence interval = 1.12–7.56; p = 0.028). Conclusions: Reduced HRV, recorded from admission and discharge ECG, appears to be a significant and independent predictor of all-cause mortality in patients with STEMI.

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Temporary decrease in cardiac parasympathetic tone after acute myocardial infarction

Cited by 53 publications

References 6 publications

Association Between Silent Coronary Artery Disease, Diabetes, and Autonomic Neuropathy: Fact or Fallacy?

Association Between Silent Coronary Artery Disease, Diabetes, and Autonomic Neuropathy: Fact or Fallacy?

Investigating the autonomic nervous system and cognitive functions as potential mediators of an association between cardiovascular disease and driving performance

Ultra-Short-Term Heart Rate Variability for Early Risk Stratification following Acute ST-Elevation Myocardial Infarction

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