Temporally resolved single cell transcriptomics in a human model of amniogenesis
Nikola Sekulovski,
Amber E Carleton,
Anusha A Rengarajan
et al.
Abstract:Amniogenesis is triggered in a collection of pluripotent epiblast cells as the human embryo implants. To gain insights into the critical but poorly understood transcriptional machinery governing amnion fate determination, we examined the evolving transcriptome of a developing human pluripotent stem cell-derived amnion model at the single cell level. This analysis revealed a previously unrecognized CLDN10+amnion progenitor cell type and enabled the identification of several markers specific to the different sta… Show more
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