Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury

Tabansky, Inna; Quinkert, Amy Wells; Rahman, Nadera; Muller, Salomon; Lofgren, Jesper; Rudling, Johan; Goodman, Alyssa A.; Wang, Ying‐Ping; Pfaff, Donald W.

doi:10.1016/j.bbr.2014.07.026

Cited by 34 publications

(27 citation statements)

References 47 publications

(49 reference statements)

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“…This network activation is associated with improvements in learning, working memory, arousal system, and waking of rat from asleep. [10,25,26] Recovery of somatosensory function among rats was associated with intact myelinated fibers connecting thalamic nucleus and somatosensory cortex as was evidenced by blood-oxygen-level-dependent response of magnetic resonance imaging (MRI) scan. [27] TBI rats treated with allopregnanolone had shown better performance in spatial performance task; allopregnanolone, a metabolite of progesterone, has shown to enhance gamma-aminobutyric acid neurotransmission in mediodorsal nucleus of thalamus.…”

Section: Preclinical and Histopathological Studies Evidence Of Thalammentioning

confidence: 99%

Role of Thalamus in Recovery of Traumatic Brain Injury

Munivenkatappa

Agrawal

2016

Journal of Neurosciences in Rural Practice

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Degree of recovery after traumatic brain injury is highly variable that lasts for many weeks to months. The evidence of brain structures involved in recovery mechanisms is limited. This review highlights evidence of the brain structure particularly thalamus in neuroplasticity mechanism. Thalamus with its complex global networking has potential role in refining the cortical and other brain structures. Thalamic nuclei activation both naturally or by neurorehabilitation in injured brain can enhance and facilitate the improvement of posttraumatic symptoms. This review provides evidence from literature that thalamus plays a key role in recovery mechanism after injury. The study also emphasize that thalamus should be specifically targeted in neurorehabilitation following brain injury.

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Section: Preclinical and Histopathological Studies Evidence Of Thalammentioning

confidence: 99%

Role of Thalamus in Recovery of Traumatic Brain Injury

Munivenkatappa

Agrawal

2016

Journal of Neurosciences in Rural Practice

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“…Potentially important for therapeutic translation of these findings, these effects were also observed in a model of traumatic brain injury [Tabansky et al 2014], although with somewhat different effects of specific patterns than observed in the arousal studies on healthy animals.…”

Section: Pattern Mattersmentioning

confidence: 96%

Temporal pattern of electrical stimulation is a new dimension of therapeutic innovation

Grill

2018

Current Opinion in Biomedical Engineering

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Artificial activation of the nervous system requires selection of appropriate stimulation parameters including stimulation amplitude, stimulation pulse duration, and stimulation pulse repetition rate. The temporal pattern of stimulation, i.e., the timing between stimulation pulses, is a novel dimension of stimulation parameter tuning. The effects evoked by artificial activation of the nervous system are dependent on the pattern of stimulation, and different patterns of stimulation, even when delivered at the same average rate, evoke different functional effects, different changes in synaptic plasticity, and even different patterns of gene expression. Non-regular temporal patterns of stimulation offer the opportunity to improve the efficacy and efficiency of therapeutic stimulation as well as to manipulate other processes in the nervous system. The potential design space for sequences of varying interpulse intervals is exceedingly large and sound approaches to design stimulation patterns are required as an empirical approach is not practical.

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“…Grouped by indications of interest, recent work in rodents and higher mammals is summarized in Table 1 . 121 , 131 – 149) …”

Section: Animal Modelsmentioning

confidence: 99%

Deep Brain Stimulation: Expanding Applications

Tekriwal

Baltuch

2015

Neurol. Med. Chir.(Tokyo)

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For over two decades, deep brain stimulation (DBS) has shown significant efficacy in treatment for refractory cases of dyskinesia, specifically in cases of Parkinson's disease and dystonia. DBS offers potential alleviation from symptoms through a well-tolerated procedure that allows personalized modulation of targeted neuroanatomical regions and related circuitries. For clinicians contending with how to provide patients with meaningful alleviation from often debilitating intractable disorders, DBSs titratability and reversibility make it an attractive treatment option for indications ranging from traumatic brain injury to progressive epileptic supra-synchrony. The expansion of our collective knowledge of pathologic brain circuitries, as well as advances in imaging capabilities, electrophysiology techniques, and material sciences have contributed to the expanding application of DBS. This review will examine the potential efficacy of DBS for neurologic and psychiatric disorders currently under clinical investigation and will summarize findings from recent animal models.

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Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury

Cited by 34 publications

References 47 publications

Role of Thalamus in Recovery of Traumatic Brain Injury

Role of Thalamus in Recovery of Traumatic Brain Injury

Temporal pattern of electrical stimulation is a new dimension of therapeutic innovation

Deep Brain Stimulation: Expanding Applications

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