Temporally and functionally distinct large-scale brain network dynamics supporting task switching

Mitsuhashi, Takumi; Sonoda, Masaki; Firestone, Ethan; Sakakura, Kazuki; Jeong, Jeong‐Won; Luat, Aimee F.; Sood, Sandeep; Asano, Eishi

doi:10.1016/j.neuroimage.2022.119126

Cited by 11 publications

(13 citation statements)

References 119 publications

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“…We delineated white matter streamlines using open-source DWI data from 1065 healthy participants ( Yeh et al, 2018 ; http://brain.labsolver.org/diffusion-mri-templates/hcp-842-hcp-1021 ), as performed before ( Mitsuhashi et al, 2021 , 2022 ; Sonoda et al, 2021 ; Ono et al, 2022 ). We placed seeds at cortical ROIs revealing significant high-gamma co-augmentation lasting ≥100 ms.…”

Section: Methodsmentioning

confidence: 99%

Intra– and inter–hemispheric network dynamics supporting object recognition and speech production

et al. 2023

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Section: Methodsmentioning

confidence: 99%

Intra– and inter–hemispheric network dynamics supporting object recognition and speech production

et al. 2023

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“…Incorrect responses (2.2% of all trials collected) were excluded from the analysis. The trial immediately following an incorrect response was also excluded due to the established effect of a prior incorrect response on subsequent set‐shifting performance 37 . Task sessions were performed at least 12 h from the last clinical or electrographic seizure event.…”

Section: Methodsmentioning

confidence: 99%

“…The trial immediately following an incorrect response was also excluded due to the established effect of a prior incorrect response on subsequent set-shifting performance. 37 Task sessions were performed at least 12 h from the last clinical or electrographic seizure event. A schematic overview of the set-shifting task is shown in Figure 1A.…”

Section: Key Pointsmentioning

confidence: 99%

Interictal discharges delay target‐directed eye movements and impair attentional set‐shifting in children with epilepsy

et al. 2022

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Objective: The theory of transient cognitive impairment in epilepsy posits that lapses in attention result from ephemeral disruption of attentional circuitry by interictal events. Eye movements are intimately associated with human attention and can be monitored in real time using eye-tracking technologies. Here, we sought to characterize the associations between interictal epileptiform discharges (IEDs), gaze, and attentional behavior in children with epilepsy. Methods: Eleven consecutive children undergoing invasive monitoring with stereotactic electrodes for localization-related epilepsy performed an attentional set-shifting task while tandem intracranial electroencephalographic signals and eye-tracking data were recorded. Using an established algorithm, IEDs were detected across all intracranial electrodes on a trial-by-trial basis. Hierarchical mixed-effects modeling was performed to delineate associations between trial reaction time (RT), eye movements, and IEDs.Results: Hierarchical mixed-effects modeling revealed that both the presence of an IED (β ± SE = 72.74 ± 24.21 ms, p = .003) and the frequency of epileptiform events (β ± SE = 67.54 ± 17.30 ms, p < .001) were associated with prolonged RT on the attentional set-shifting task. IED occurrence at the time of stimulus presentation was associated with delays in gaze initiation toward the visual targets (p = .017). Significance:The occurrence of epileptiform activity in close temporal association with stimulus presentation is associated with delays in target-directed gaze and prolonged response time, hallmarks of momentary lapses in attention. These findings provide novel insights into the mechanisms of transient impairments in children and support the use of visual tracking as a correlate of higher order attentional behavior.

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“…As previously performed, 42,73 we used the open-source DWI tractography data from 1,065 individuals participating in the Human Connectome Project (http://brain.labsolver.org/diffusion-mri-templates/hcp-842-hcp-1021). 74 Our previous study validated the use of open-source DWI data by demonstrating that the dynamics of neural propagations via the white matter pathways based on the open-source data were similar to those found in the individual DWI data.…”

Section: Methodsmentioning

confidence: 99%

Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities

Ono

Sonoda

Sakakura

et al. 2022

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Alpha waves - posterior-dominant rhythms at 8-12 Hz reactive to eye opening and closure - are among the most fundamental EEG findings in clinical practice and research since Hans Berger first documented them in the early 20th century. Yet, the exact network dynamics of alpha waves in regard to eye movements remains unknown. High-gamma activity at 70-110 Hz is also reactive to eye movements and a summary measure of local cortical activation supporting sensorimotor or cognitive function. We aimed to build the first-ever brain atlases directly visualizing the network dynamics of eye movement-related alpha and high-gamma modulations, at cortical and white matter levels. We studied 28 patients (age: 5-20 years) who underwent intracranial EEG and electrooculography recordings. We measured alpha and high-gamma modulations at 2,170 electrode sites outside the seizure onset zone, interictal spike-generating areas, and MRI-visible structural lesions. Dynamic tractography animated white matter streamlines modulated significantly and simultaneously beyond chance, on a millisecond scale. Before eye closure onset, significant alpha augmentation occurred at the occipital and frontal cortices. After eye closure onset, alpha-based functional connectivity was strengthened, while high gamma-based connectivity was weakened extensively in both intrahemispheric and interhemispheric pathways involving the central visual areas. The inferior fronto-occipital fasciculus supported the strengthened alpha coaugmentation-based functional connectivity between occipital and frontal lobe regions, whereas the posterior corpus callosum supported the interhemispheric functional connectivity between the occipital lobes. After eye opening offset, significant high gamma augmentation and alpha attenuation occurred at occipital, fusiform, and inferior parietal cortices. High gamma coaugmentation-based functional connectivity was strengthened, whereas alpha-based connectivity was weakened in the posterior interhemispheric and intrahemispheric white matter pathways involving central and peripheral visual areas. Proactive and reactive alpha waves involve extensive, distinct white matter networks that include the frontal lobe cortices, along with low- and high-order visual areas. High-gamma co-attenuation coupled to alpha co-augmentation in shared brain circuitry after eye closure supports the notion of an idling role for alpha waves during eye closure. These dynamic tractography atlases may improve understanding of the significance of EEG alpha waves in assessing the functional integrity of brain networks in clinical practice; they also may help elucidate the effects of eye movements on task-related brain network measures observed in cognitive neuroscience research.

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Temporally and functionally distinct large-scale brain network dynamics supporting task switching

Cited by 11 publications

References 119 publications

Intra– and inter–hemispheric network dynamics supporting object recognition and speech production

Intra– and inter–hemispheric network dynamics supporting object recognition and speech production

Interictal discharges delay target‐directed eye movements and impair attentional set‐shifting in children with epilepsy

Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities

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