Temporal variability in urinary levels of drinking water disinfection byproducts dichloroacetic acid and trichloroacetic acid among men

Wang, Yixin; Zeng, Qiang; Wang, Le; Huang, Yue-Hui; Lu, Zhiwei; Wang, Peng; He, Mengjie; Huang, Xin; Lu, Wen-Qing

doi:10.1016/j.envres.2014.05.035

Cited by 46 publications

(34 citation statements)

References 29 publications

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“…Some biomarkers, mostly urinary ones, have been suggested to evaluate exposure to chlorine-based disinfectants or exposure to drinking water disinfection by-products (e.g. trihalomethanes (THM), haloacetic acids) [81][82][83] . Such biomarkers, especially THM, might also be relevant to evaluate exposure to cleaning agents as THM exposures during household cleaning tasks were shown to strongly influence urinary THM levels, both in adults and children (passive exposure) 82,84 .…”

Section: Improvement Of Evaluation Of Irritants At Risk For Asthma Inmentioning

confidence: 99%

“…Such biomarkers, especially THM, might also be relevant to evaluate exposure to cleaning agents as THM exposures during household cleaning tasks were shown to strongly influence urinary THM levels, both in adults and children (passive exposure) 82,84 . However, limitations of some urine biomarkers have been underlined and include rapid metabolic turnover (THM), the choice of urinary collection (24-hours, timed, spot urine samples) and the poor reproducibility of the measured urinary concentrations 81,[83][84][85] . Further research is thus needed to determine relevant biomarkers, for chlorinated as well as non-chlorinated cleaning products.…”

Section: Improvement Of Evaluation Of Irritants At Risk For Asthma Inmentioning

confidence: 99%

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Do chronic workplace irritant exposures cause asthma?

Dumas

Moual

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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Evidence of a causal effect of chronic workplace irritant exposure in new-onset asthma remains limited, mainly because of a lack of longitudinal studies and the difficulty to evaluate irritant exposures. However, recent epidemiological studies strengthen the evidence of an effect of chronic exposure to irritants in work-related asthma. The underlying mechanism remains unknown but may be related to oxidative stress, neurogenic inflammation and dual irritant and adjuvant effects. However, disentangling chronic irritant effects from either acute irritant-induced asthma or immunological low molecular weight agent-induced asthma is difficult for some agents. Further research is needed to improve assessment of irritant exposures and identify biomarkers.

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Section: Improvement Of Evaluation Of Irritants At Risk For Asthma Inmentioning

confidence: 99%

Section: Improvement Of Evaluation Of Irritants At Risk For Asthma Inmentioning

confidence: 99%

Do chronic workplace irritant exposures cause asthma?

Dumas

Moual

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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“…From 22 October 2012 to 21 January 2013, eleven healthy adult men were recruited to participate in the study designed to explore the variability in urinary heavy metals and haloacetic acids (18,23) . Their basic demographics have been shown in our previous study (18) .…”

Section: Study Populationmentioning

confidence: 99%

“…To reduce the effect of changing dietary patterns on the weekend (24) , all the samples were collected on weekdays. Detailed sampling procedure has been described in our prior publications (18,23) . Briefly, participants were asked to collect all their spot samples in element-free plastic containers throughout the sampling days.…”

Section: Urine Sample Collectionmentioning

confidence: 99%

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Reproducibility of essential elements chromium, manganese, iron, zinc and selenium in spot samples, first-morning voids and 24-h collections from healthy adult men

Chen

et al. 2019

Br J Nutr

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Evaluation of Cr, Mn, Fe, Zn and Se in humans is challenged by the potentially high within-individual variability of these elements in biological specimens, which are poorly characterised. This study aimed to evaluate their within-day, between-day and between-month variability in spot samples, first-morning voids and 24-h collections. A total of 529 spot urine samples (including eighty-eight first-morning voids and 24-h collections) were collected from eleven Chinese adult men on days 0, 1, 2, 3, 4, 30, 60 and 90 and analysed for these five elements using inductively coupled plasma-MS. Intraclass correlation coefficients (ICC) were utilised to characterise the reproducibility, and their sensitivity and specificity were analysed to assess how well a single measurement classified individuals’ 3-month average exposures. Serial measurements of Zn in spot samples exhibited fair to good reproducibility (creatinine-adjusted ICC = 0·47) over five consecutive days, which became poor when the samples were gathered months apart (creatinine-adjusted ICC = 0·33). The reproducibility of Cr, Mn, Fe and Se in spot samples was poor over periods ranging from days to months (creatinine-adjusted ICC = 0·01–0·12). Two spot samples were sufficient for classifying 60 % of the men who truly had the highest (top 33 %) 3-month average Zn concentrations; for Cr, Mn, Fe and Se, however, at least three specimens were required to achieve similar sensitivities. In conclusion, urinary Cr, Mn, Fe, Zn and Se concentrations showed a strong within-individual variability, and a single measurement is not enough to efficiently characterise individuals’ long-term exposures.

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