Temporal trends of perfluorooctanesulfonate isomer and enantiomer patterns in archived Swedish and American serum samples

Liu, Yanna; Pereira, André; Beesoon, Sanjay; Vestergren, Robin; Berger, Urs; Olsen, Geary W.; Glynn, Anders; Martin, Jonathan W.

doi:10.1016/j.envint.2014.11.014

Cited by 36 publications

(33 citation statements)

References 69 publications

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“…This is contrary to two independent studies where the serum of Swedes was reported to increase in branched PFOS content over the same period [85,109]. Liu et al [109] suggested that the branched PFOS isomer pattern, and concomitant increasingly non-racemic proportions of 1 m-PFOS isomer in the same Swedish serum samples, post year 2000, indicated a role of PFOS-precursors in human exposure.…”

Section: Pfos Change Point Analysiscontrasting

confidence: 54%

“…One inconsistent result is that the PFOS isomer pattern (linear: branched) in eggs has become more linear over time, increasing from approximately 1:1 in year 2000 to approximately 3:1 in the year 2010 [99]. This is contrary to two independent studies where the serum of Swedes was reported to increase in branched PFOS content over the same period [85,109]. Liu et al [109] suggested that the branched PFOS isomer pattern, and concomitant increasingly non-racemic proportions of 1 m-PFOS isomer in the same Swedish serum samples, post year 2000, indicated a role of PFOS-precursors in human exposure.…”

Section: Pfos Change Point Analysiscontrasting

confidence: 54%

See 1 more Smart Citation

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

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162

122

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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Section: Pfos Change Point Analysiscontrasting

confidence: 54%

Section: Pfos Change Point Analysiscontrasting

confidence: 54%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

Self Cite

162

122

View full text Add to dashboard Cite

show abstract

“…In Swedish serum samples only the PFOS precursor FOSA was analyzed so far with rapidly declining concentrations between 1996 and 2010 (Glynn et al, 2012). On the other hand, Liu et al (2015) recently suggested that the relative importance of PFOS precursors for total internal exposure to PFOS has increased in the Swedish population (based on isomer and enantiomer pattern biomarkers). However, it is unclear which PFOS precursors (other than FOSA) and PFCA precursors the Swedish population has been and still is exposed to.…”

Section: Introductionmentioning

confidence: 99%

Temporal changes (1997–2012) of perfluoroalkyl acids and selected precursors (including isomers) in Swedish human serum

Gebbink

Glynn

Berger

2015

Environmental Pollution

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Concentrations (including isomer patterns) and temporal changes (1997-2012) of perfluoroalkyl acids (PFAAs) and selected perfluorooctane sulfonate (PFOS) and perfluoroalkyl carboxylic acid (PFCA) precursors were determined in serum samples from Swedish women. Perfluorooctane sulfonamide (FOSA) and perfluorooctane sulfonamidoacetic acid (FOSAA), as well as its N-methyl and N-ethyl derivatives (MeFOSAA and EtFOSAA) were consistently detected. Highest PFOS precursor concentrations were found for EtFOSAA (before year 2000) or MeFOSAA and FOSAA (after 2000). Disappearance half-lives for all PFOS precursors were shorter compared to PFOS. 4:2/6:2 and 6:2/6:2 polyfluoroalkyl phosphate diesters (diPAPs) were detected in <60% of the samples, whereas 6:2/8:2 and 8:2/8:2 diPAPs were detected in >60% of the samples, but showed no significant change in concentrations over time. Linear and sum-branched isomers were quantified separately for three PFAAs and three precursors. Significant changes between 1997 and 2012 in the % linear isomer were observed for PFOA and FOSA (increase) and PFOS (decrease).

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“…20 ng PFOS/ml für Frauen und 10 ng PFOS/ml für Kinder <10 Jahre) [45]. Generell zeigt sich für die Zeit nach 2002 ein abnehmender Trend der PFOS-Konzentrationen im Blut [46][47][48][49][50][51][52][53][54] …”

Section: Verbreitung Und Exposition Des Menschenunclassified

Ableitung von HBM-I-Werten für Perfluoroktansäure (PFOA) und Perfluoroktansulfonsäure (PFOS) – Stellungnahme der Kommission „Humanbiomonitoring“ des Umweltbundesamts

Umweltbundesamt¹

2018

Bundesgesundheitsbl

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Temporal trends of perfluorooctanesulfonate isomer and enantiomer patterns in archived Swedish and American serum samples

Cited by 36 publications

References 69 publications

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Temporal changes (1997–2012) of perfluoroalkyl acids and selected precursors (including isomers) in Swedish human serum

Ableitung von HBM-I-Werten für Perfluoroktansäure (PFOA) und Perfluoroktansulfonsäure (PFOS) – Stellungnahme der Kommission „Humanbiomonitoring“ des Umweltbundesamts

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