Temporal trends in sperm count: a systematic review and meta-regression analysis

Levine, Hagai; Jørgensen, Niels; Martino‐Andrade, Anderson Joel; Mendiola, Jaime; Weksler-Derri, Dan; Mindlis, Irina; Pinotti, Rachel; Swan, Shanna H.

doi:10.1093/humupd/dmx022

Cited by 1,007 publications

(724 citation statements)

References 209 publications

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“…Her er der et forskningsbehov, der skal daekkes. En ny undersøgelse viser fortsat fald i saedkvalitet op til vor tid (27), men data er fortsat for dårlige til egentlige konklusioner. Også de nye studier gentager mange af de problemer der var i BMJ-artiklen, selektionsbias, misspecifikation af studiepopulation, ukontrolleret confounding etc.…”

Section: Nye Forskningområderunclassified

Løbende nationale reproduktionsregistre og ad hoc data

Olsen

2017

Nor J Epidemiol

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ENGLISH SUMMARYOlsen J. National registration in human reproduction and research oriented ad hoc data. Nor J Epidemiol 2017; 27 (1-2): 27-31.The Nordic countries have a long tradition for collecting and storing of data in reproductive health. These registers cover the entire population and focus on health outcomes. They have gradually been made available for research and if supplemented with data on potential risk factors in reproductive health, they provide a strong basis for research in potential causes of disease in the reproductive system. Several pregnany/birth cohorts have been successful in providing important information in preventive medicine. The most important of these are the Norwegian birth cohort (MoBa) and the Danish National Birth Cohort (DNBC). Both include about 100,000 newborns. They are based on the rationale that many diseases have causes that start operating in fetal life -fetal programming of diseases -even diseases that manifest themselves later in life (adult diseases). Examples of historic and more recent findings are presented in the following text. Risk of disclosure of personal data is of concern. We have not had examples of such unwanted disclosure and we want to keep this achievement. We clearly have to do many things different and better in the future. Fortunately, technical solutions are available and promising.The registers and the ad hoc data sources have given the Nordic epidemiologists a leading position in reproductive health. To keep that position, we need to plan new cohorts and train more people. If we do that we will be able to continue our collaboration with colleagues all over the world.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Nye Forskningområderunclassified

Løbende nationale reproduktionsregistre og ad hoc data

Olsen

2017

Nor J Epidemiol

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“…In addition, people from North America, Europe, Australia and New Zealand have significant (about 50%) drop in sperm counts in ejaculated semen (6). Further insights into the cellular and molecular properties of human spermatogonia stem cells (hSSCs) and the mechanisms for the development of functional germ cells are necessary to understand the rising rates of infertility.…”

mentioning

confidence: 99%

Epigenomic and single-cell profiling of human spermatogonial stem cells

Sakashita

Yeh

Namekawa

et al. 2018

Stem Cell Investig.

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“…Male infertility describes any factor in men that may prevent a couple from becoming pregnant. In nearly half of infertility cases, the male partner has suboptimal sperm parameters 23. Some cases of idiopathic infertility may have underlying male aetiology.…”

mentioning

confidence: 99%