Temporal trends in multiple sclerosis prevalence and incidence in a large population

Rotstein, Dalia; Chen, Hong; Wilton, Andrew S.; Kwong, Jeffrey C.; Marrie, Ruth Ann; Gozdyra, Peter; Krysko, Kristen M.; Kopp, Alexander; Copes, Ray; Tu, Karen

doi:10.1212/wnl.0000000000005331

Cited by 67 publications

(58 citation statements)

References 24 publications

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“…The relative effects of changes in MS survival and incidence are reflected in prevalence. As the recent incidence and sex difference seem to have stabilized and the global trends in mortality have decreased, the general increase in prevalence is largely explained by increasing survival in MS population, which may largely explain for the ten‐year change also in our data. The incidence up to 2010 in the three hospital districts under study has earlier shown high female versus male ratios and both increase (in Pirkanmaa) and stability (in Seinäjoki and Vaasa) in total trends .…”

Section: Discussionmentioning

confidence: 55%

“…Epidemiological observations in multiple sclerosis (MS) have consistently pointed at globally increasing prevalence . At the same time, MS mortality has decreased, and analyses on incidence have shown both stability and increase . The highest age‐standardized estimates have been observed in northern latitudes where prevalence among women and in relapsing‐remitting MS is high.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 At the same time, MS mortality has decreased, and analyses on incidence have shown both stability and increase. [2][3][4][5] The highest age-standardized estimates have been observed in northern latitudes where prevalence among women and in relapsing-remitting MS is high. The relationship between socioeconomic determinants and increase in MS occurrence is observed, occurrence being higher in areas of higher socioeconomic level.…”

Section: Introductionmentioning

confidence: 99%

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Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Murtonen

Sumelahti

2020

Acta Neurol Scand

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Objective To study ten‐year change in MS prevalence in the Province of Western Finland in Tampere University Hospital District located in 62.7°N, 23.7°E. Methods Age‐standardized prevalence/105 by using direct standardization in European Standard Population (ESP2013) and crude prevalence/105 with 95% confidence interval (95% CI) were assessed among resident MS cases fulfilling Poser criteria by sex and disease course in 31.12.2000 and 31.12.2010. MS‐related disability and disease‐modifying treatment (DMT) use were estimated in 31.12.2010. Results Crude prevalence increased 49% from 129/105 (95% CI 121‐137) in 2000 (N 1080) to 196/105 (187‐203) in 2010 (N 1666). Age‐standardized prevalence increased 45% from 133/105 (127‐140) to 192/105 (184‐200) and peaked in 40‐ to 49‐year age‐group. Age‐standardized prevalence increased 58% among women from 176/105 (171‐176) to 277/105 (270‐284) and 31% among men from 91/105 (87‐95) to 119/105 (115‐124). Increase in RRMS was 61% from 111/105 (105‐117) to 179/105 (171‐186), and decrease in PPMS was 14% from 21/105 (19‐24) to 18/105 (15‐21). In 2010 among the 52% RRMS cases on DMT, MS‐related disability was mild in 50%. In total, cohort disability was mild in 46%, moderate to severe in 47%, and information was not available in 14%. Conclusion A significant increase in prevalence was observed in Western Finland. Increase was higher among women and in relapsing‐remitting onset MS. Disability showed age‐ and disease course‐specific variation.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Murtonen

Sumelahti

2020

Acta Neurol Scand

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“…This figure increased to more than 200 in one hundred thousand in Kingwell et al study in 2013 [17].. In Canada, there has been a dramatic increase in the prevalence of MS from 157 in 1996 to 265 per hundred thousand population in 2013 [18]. In the United States, the MS prevalence rate was estimated at 85 per 100.000 people in 2002 [19], while, 8 years later, studies conducted in three different regions of the United States, showed an increase of up to 109 per 100,000 population in the prevalence of this disease [20].…”

Section: Discussionmentioning

confidence: 99%

Does the multiple sclerosis (MS) map need to change again? An update of MS prevalence in Mazandaran province of Iran in 2018

et al. 2020

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Background: Information of Previous studies on the prevalence of MS, including our study conducted 12 years ago, used to shape global prevalence map of MS. According to those results, Iran placed in medium-prevalence MS region in the world Atlas of MS 2013.This study aimed to investigate the prevalence of MS in Mazandaran province after 12 years and the need for possible changes in the global map of the prevalence of MS. Methods: We included all MS patients living in Mazandaran province in 2018 in this descriptive cross-sectional study. We updated our pre-existing registration questionnaires which included demographic information and medical data of MS patients by interview. We obtained the demographic profile of Mazandaran province from the most recent census in 2016 and the National Civil Registry of the Mazandaran province for calculating prevalence of MS. Results: The total number of MS patients in Mazandaran was 2418 (25.8% male and 74.2% female) with a female to male ratio of 2.9. Based on the local population of 3,332,556, (50.4% male and 49.6% female), this study showed a prevalence of 72.5 per 100,000 for MS in this region. The prevalence of this disease by gender was 37.1 per 100,000 for men and 108.5 per 100,000 for women. The mean (SD) age of the patients at the time of the study was 38.5 (10.1) years with a minimum of 15 and a maximum of 75 years. The most common type of MS was Relapsing-Remitting MS with 86%. Conclusions: All recent studies showed significant upward trend in the prevalence of MS around the world. Based on the results of our study and many other studies in Iran, the Atlas of MS prevalence map needs to be update. Iran's status should be changed to the high-prevalence of MS in the new Atlas. Due to the increasing prevalence of MS, we suggest an adjustment in the Global MS Prevalence Scale.

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“…. In Canada, there has been a dramatic increase in the prevalence of MS from 157 in 1996 to 265 per hundred thousand population in 2013(18). In the United States, the MS prevalence rate was estimated at 85 per 100.000 people in 2002(19), while, eight years later, studies conducted in three different regions of the United States, showed an increase of up to 109 per 100,000 population in the prevalence of this disease(20).Although these findings hypothesized the sunlight and UV role in the pathogenesis of MS, but many studies did not support this hypothesis.…”

mentioning

confidence: 99%

Does the Multiple Sclerosis (MS) Map need to change again? An update of MS prevalence in Mazandaran province of Iran in 2018.

Baghbanian

Cheraghmakani

HabibiSaravi

et al. 2019

Preprint

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Background: Information of Previous studies on the prevalence of MS, including our study conducted twelve years ago, used to shape global prevalence map of MS. According to those results, Iran placed in medium-prevalence MS region in the world Atlas of MS 2013.This study aimed to investigate the prevalence of MS in Mazandaran province after twelve years and the need for possible changes in the global map of the prevalence of MS. Methods: We included all MS patients living in Mazandaran province in 2018 in this descriptive cross-sectional study. We updated our pre-existing registration questionnaires which included demographic information and medical data of MS patients by interview. We obtained the demographic profile of Mazandaran province from the most recent census in 2016 and the National Civil Registry of the Mazandaran province for calculating prevalence of MS. Results: The total number of MS patients in Mazandaran was 2418 (25.8% male and 74.2% female) with a female to male ratio of 2.9. Based on the local population of 3332556, (50.4% male and 49.6% female), this study showed a prevalence of 72.5 per 100,000 for MS in this region. The prevalence of this disease by gender was 37.1 per 100,000 for men and 108.5 per 100,000 for women. The mean (SD) age of the patients at the time of the study was 38.5 (10.1) years with a minimum of 15 and a maximum of 75 years. The most common type of MS was Relapsing-Remitting MS with 86%. Conclusions: All recent studies showed significant upward trend in the prevalence of MS around the world. Based on the results of our study and many other studies in Iran, the Atlas of MS prevalence map needs to be update. Iran's status should be changed to the high-prevalence of MS in the new Atlas. Due to the increasing prevalence of MS, we suggest an adjustment in the Global MS Prevalence Scale.

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Temporal trends in multiple sclerosis prevalence and incidence in a large population

Cited by 67 publications

References 24 publications

Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Multiple sclerosis prevalence in 2000 and 2010 in Western Finland

Does the multiple sclerosis (MS) map need to change again? An update of MS prevalence in Mazandaran province of Iran in 2018

Does the Multiple Sclerosis (MS) Map need to change again? An update of MS prevalence in Mazandaran province of Iran in 2018.

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