Temporal Trends in Long-Term Survival and Cure Rates in Esophageal Cancer: A SEER Database Analysis

Dubecz, Attila; Gall, Isabell; Solymosi, Norbert; Schweigert, Michael; Peters, Jeffrey H.; Feith, Marcus; Stein, Hubert J.

doi:10.1097/jto.0b013e3182397751

Cited by 174 publications

(158 citation statements)

References 16 publications

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“…Due to the improvement of endoscopy and staining methods, the detection rate of EEC in our hospital rose significantly in the past five years, and reached to nearly 10%. But the detection rate is still lower than that of 15%-30% in Japan and western countries (Natsugoe et al, 2004;Stein et al, 2005;Saha et al, 2009;Bogoevski et al, 2011;Dubecz et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment for Early Esophageal Squamous Cell Carcinoma

Chen

Weng²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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More studies are needed to clarify treatments and prognosis of early esophageal squamous cell carcinoma (ESCC). This retrospective study was designed to review the outcome of surgical treatment for early ESCC, evaluate the results of a left thoracotomy for selected patients with early ESCC, and identify factors affecting lymph node metastases and survival. The clinicopathological data of 228 patients with early ESCC who underwent transthoracic esophagectomy with lymphadenectomy without preoperative adjuvant treatment were reviewed. The χ 2 test or Fisher's exact test were used to detect factors related to lymph node metastasis. Univariate and multivariate analyses were performed to identify prognostic factors. There were 152 males and 76 females with a median age of 55 years. Two hundred and eight patients underwent a left thoracotomy, and the remaining 20 patients with lymph nodes in the upper mediastinum more than 5 mm in short-axis diameter by computed tomography scan underwent a right thoracotomy. No lymph node metastasis was found in the 18 patients with carcinoma in situ, while lymph node metastases were detected in 1.6% (1/62) of patients with mucosal tumours and 18.2% (27/148) of patients with submucosal tumours. Only 7 patients showed upper mediastinal lymph node metastases in the follow-up. The 5-and 10-year overall survival rates were 81.4% and 70.1%, respectively. Only histologic grade (P<0.001) and pT category (P=0.001) significantly correlated with the presence of lymph node metastases. In multivariate analysis, only histologic grade (P=0.026) and pT category (P=0.008) were independent prognostic factors. A left thoracotomy is acceptable for selected patients with early ESCC. Histologic grade and pT category affected the presence of lymph node metastases and were independent prognostic factors for early ESCC.

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment for Early Esophageal Squamous Cell Carcinoma

Chen

Weng²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Several individual studies (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)27) and 2 systematic reviews (that produced essentially identical results despite slightly different methodologies (16,17)) have reported that statin use, and particularly statin use combined with a cyclo-oxygenase inhibitor, is associated with a reduced incidence of esophageal adenocarcinoma. This has been reported in cohort studies and case-control studies of Barrett's patients and population-based studies compared to population-based controls, although not all studies are in agreement (28).…”

Section: Discussionmentioning

confidence: 99%

“…It is accepted that metaplastic transformation of the esophageal squamous mucosa to intestinaltype mucosa (Barrett's esophagus (BE)) is a premalignant phenotype, although the overall rate of progression is relatively low (probably about 1 in 300 patients per year, or less) (5)(6)(7) and this has allowed the development of surveillance and localised treatment strategies such as radio-frequency ablation as means of preventing the development of EAC (8). However overall mortality from EAC remains considerable with 5-year survival less than 25% (9).…”

Section: Introductionmentioning

confidence: 99%

Reduced Risk of Barrett’s Esophagus in Statin Users: Case–Control Study and Meta-Analysis

et al. 2015

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“…Over the past 3 decades, surgical advances and improvement in radiation techniques have greatly improved the disease outcomes. [9][10][11] This article focuses on integrating these approaches and tailoring the treatment strategy for individual patients, compares the effectiveness of the various treatment approaches in the definitive or neoadjuvant…”

Section: Introductionmentioning

confidence: 99%

Esophageal cancer: comparative effectiveness of treatment options

Cai¹,

Lin²

2016

CER

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Esophageal cancer is a lethal disease. Multimodal therapy has improved the survival and local control for locally advanced esophageal cancer compared to surgery alone. Neoadjuvant chemoradiotherapy (CRT) plus surgery is the accepted standard of care for operable esophageal cancer. Pathologic complete response is very common, ranging from 18% to 43%, and it is an independent favorable prognostic factor for survival. Salvage surgery after definitive CRT may be safe and feasible for patients with esophageal cancer who achieve pathologic complete response after neoadjuvant CRT. For inoperable cases, definitive CRT is an alternative treatment modality. Intensity-modulated radiation therapy may reduce treatment-related toxicities due to its better dose homogeneity and conformity compared to three-dimensional conformal radiotherapy. Proton therapy can further improve target conformity and normal tissue sparing when compared to photon therapy (three-dimensional conformal radiotherapy and intensitymodulated radiation therapy) and, therefore, likely to further improve the treatment outcomes of patients. This article compares the effectiveness of the various treatment approaches in the definitive or neoadjuvant setting and reviews the evidence on the benefit of utilizing advanced radiation techniques for the curative management of esophageal cancer.

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Temporal Trends in Long-Term Survival and Cure Rates in Esophageal Cancer: A SEER Database Analysis

Abstract: Long-term survival with esophageal cancer is poor but survival of local esophageal cancer improved dramatically over the decades. Complete cure of nonmetastatic esophageal cancer seems possible in a growing number of patients. Early diagnosis and treatment are crucial.

Cited by 174 publications

References 16 publications

Surgical Treatment for Early Esophageal Squamous Cell Carcinoma

Surgical Treatment for Early Esophageal Squamous Cell Carcinoma

Reduced Risk of Barrett’s Esophagus in Statin Users: Case–Control Study and Meta-Analysis

Esophageal cancer: comparative effectiveness of treatment options

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