Temporal trends and socioeconomic differences in the incidence of left-sided valvular heart disease in Denmark

Abstract

Aims Due to an ageing population and increasing survival from concurrent diseases, the burden of left-sided degenerative valvular heart disease is expected to increase over time. This study aims at determining the temporal trends in incidence rates at the population level and examines whether there are socioeconomic differences. Methods and results A total of 133 209 patients were identified with a first-time diagnosis of aortic stenosis (AS), mitral regurgitation (MR), or aortic regurgitation (AR) in the Danish National Patient Registry in the 2000–17 period. Incidence rates (per 100 000 person-years) doubled over the period for AS (57 in 2000–02; 114 in 2015–17) and for AR (22 in 2000–02; 41 in 2015–17) and remained the same for MR (38 in both 2000–02 and 2015–17). Incidence rates increased rapidly with increasing age, most markedly for AS. Men had a higher risk of being affected [relative risk (RR) 1.69 for AS, 1.19 for MR, 1.35 for AR]. Compared to high-level education, patients with medium- and low-level education had a higher risk of being affected (RR 1.18 for AS medium level and 1.47 for AS low level; 1.03 for MR medium level and 1.14 for MR low level; 1.03 for AR medium level and 1.18 for AR low level). Conclusions For AS and AR, the incidence rates doubled, while the incidence rates remained at the same level for MR. The risk of being affected increased with advanced age and male gender. Patients with low-level education had a higher risk of being affected compared to patients with high-level education, especially among patients with AS.

Valvular Heart Disease Epidemiology

“…Data on the AR rates in these nations are largely unavailable. The age-standardized incidence of AR in Denmark increased from 2000 to 2017, similar to ASVD [44], though, unlike ASVD, AR is not known to be significantly associated with atherosclerosis. Acute AR can present with rapid cardiogenic shock, while chronic AR has a long asymptomatic period followed by gradual, progressive dyspnea.…”

Efficacy of metoprolol combined with torasemide in elderly patients with degenerative valvular heart disease and heart failure and its influence on NT-proBNP levels

“…Reagents and instruments for plasma IL-1, TNF -and IL-6 were provided by Siemens Immune 1000 [W2], Beijing North Biotechnology Research Institute and Backman Coulter of the United States, respectively. Efficacy evaluation: 9 After one week of treatment, if the relevant clinical signs and symptoms of the patient partially or completely disappeared, and the cardiac function improved to Grade-I compared with that before treatment, which was judged to be significantly effective. After treatment, if Grade-I of the patient's relevant signs and symptoms were significantly improved compared with those before treatment, and the cardiac function was improved to Grade-I compared with those before treatment, which was determined as effective.…”

Temporal trends and socioeconomic differences in treatment and mortality following a diagnosis of aortic stenosis

“…When including outpatients in their analysis, they found the treatment rate decreased slightly towards the end of the period. The proportion of outpatients is increasing [23] and it is likely that outpatients have more asymptomatic or less severe aortic stenosis at the time of diagnosis. The incidence rate of aortic stenosis almost doubled a Due to lack of follow-up time for patients diagnosed in 2017, the period is 2015-2016 for 1-year surgery and death proportion.…”

“…between 2000 and 2017 [23]. However, it is unknown if the increase is due to earlier detection of less severe aortic stenosis.…”

“…The increasing incidence and prevalence of aortic stenosis leads to more patients potentially eligible for AVR [5,22,23]. During the last two decades there has been a decline in mortality rates after AVR, and patient comorbidity and risk factor profiles have improved [24][25][26][27].…”