2023
DOI: 10.1111/tmi.13877
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Temporal trend, spatial analysis and spatiotemporal clusters of infant mortality associated with congenital toxoplasmosis in Brazil: Time series from 2000 to 2020

Abstract: Objective To analyse the spatial, temporal and spatial–temporal patterns of infant mortality associated with congenital toxoplasmosis in Brazil between the years 2000 and 2020. Methods Ecological study of time series, with spatial analysis and spatiotemporal scan of infant mortality associated with congenital toxoplasmosis from the records of deaths of the Mortality Information System of the Brazilian Ministry of Health. The rates were smoothed by the Local Empirical Bayesian model. The Global Moran Index, Glo… Show more

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Cited by 6 publications
(5 citation statements)
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“…A limitation of the present study is that no differentiation between acute and chronic phases was made, as no IgM or antibody avidity tests were performed for either pathogen. Nonetheless, infant mortality associated with congenital toxoplasmosis has been a persistent public health problem in Brazil ( 72 ). A surveillance protocol for gestational toxoplasmosis has been recently established by the Brazilian Minister of Health, including systematic serodiagnosis, compulsory notification, and educational and preventive activities coordinated by the Unified Health System ( 73 ).…”
Section: Discussionmentioning
confidence: 99%
“…A limitation of the present study is that no differentiation between acute and chronic phases was made, as no IgM or antibody avidity tests were performed for either pathogen. Nonetheless, infant mortality associated with congenital toxoplasmosis has been a persistent public health problem in Brazil ( 72 ). A surveillance protocol for gestational toxoplasmosis has been recently established by the Brazilian Minister of Health, including systematic serodiagnosis, compulsory notification, and educational and preventive activities coordinated by the Unified Health System ( 73 ).…”
Section: Discussionmentioning
confidence: 99%
“…While high-income countries have observed a decrease in the prevalence of toxoplasmosis in recent decades [ 8 , 9 , 10 ], Brazil has experienced a heterogeneous increase in the prevalence of the disease with varying impacts across different regions of the country [ 11 ]. The discussion will be subdivided into three topics for a better understanding and exploration of the inherently different aspects between the investigated groups: (1) knowledge of toxoplasmosis among pregnant women in Brazil and worldwide; (2) knowledge of toxoplasmosis among healthcare providers in Brazil and worldwide; and (3) additional considerations in toxoplasmosis education and study limitations.…”
Section: Discussionmentioning
confidence: 99%
“…Recent data indicate a decreasing trend in its global prevalence [ 8 , 9 , 10 ]. Nonetheless, in Brazil, there has been a recent and worrisome increase in reported deaths that can be associated with congenital toxoplasmosis, necessitating a more thorough examination of this trend [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…These differences may depend heavily on food consumption preferences between countries; even within our analysis, the estimated incidence from a given food group could be 1.5–2 times higher between the lowest and highest regions ( Table 3 ). Regional heterogeneity of infections was also present in a recent retrospective analysis of infant mortality associated with congenital toxoplasmosis in Brazil, suggesting that regional exposure risk differences can play a role in pathogen transmission [ 56 ]. Predicted infections from oocyst exposure through the consumption of fresh produce (i.e., fruits and greens) were up to 100 times greater than infections from eating meat ( Table 3 ), which may be an overestimate of the actual relative importance of produce due to assumptions made in our baseline model on oocyst load and viability as discussed below.…”
Section: Discussionmentioning
confidence: 99%