Temporal trend in early sepsis in a very low birth weight infants' cohort: an opportunity for a rational antimicrobial use

Caldas, Jamil Pedro de Siqueira; Montera, Lorenna Cristina; Calil, Roseli; Marba, Sérgio Tadeu Martins

doi:10.1016/j.jped.2020.07.006

Cited by 2 publications

(2 citation statements)

References 24 publications

(35 reference statements)

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“…The feature of the current study's finding is a global feature and a concern as well, as seen in Tanzania [14]. Though the magnitudes of the average percentage change vary, the current incidence trend is in the same direction as the declining percentage changes in Brazil [51], India [39], the United States, and the 2020 global report [13,52]. Of note, the current study result implies an inconsistent decline in the incidence trend, necessitating close monitoring of the progress toward the global neonatal sepsis initiatives in the study area.…”

Section: Plos Onementioning

confidence: 52%

Epidemiologic features of neonatal sepsis and its COVID-19 associated temporal patterns in Jimma Medical Center, Ethiopia: A Joinpoint regression analysis

Geleta,

Abebe,

Workneh

et al. 2023

PLoS ONE

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Background Neonatal sepsis remains a leading cause of morbidity and mortality in neonates across all regions, including Africa. Compared to developed and some developing countries, there are relatively few epidemiological trends for neonatal sepsis and associated patterns with COVID-19 in Ethiopia. We modeled an epidemiological trend and pattern to aid in the monitoring of changes in neonatal sepsis. Methods Retrospective data were collected from all admissions to the Neonatal Intensive Care Unit (NICU) in Ethiopia at Jimma Medical Center between May 2019 and April 2022. We analyzed the monthly neonatal sepsis incidence, mortality, and case-fatality rates using STATA software. Finally, we modeled a monthly time series of neonatal sepsis incidence trends and patterns associated with the COVID-19-impacted period using Joinpoint software. For all analyses, a P value of 0.05 was considered statistically significant at the 95% confidence interval (CI). Results In the 36 months, 6796 cases were admitted to the NICU, with a 9.5% (95% CI: 9.1, 10.0) incidence rate of neonatal sepsis. The overall admission mortality rate was 16.5% (95% CI: 13.6, 19.8), while sepsis-attributed mortality was 7.1% (95% CI: 5.8, 8.5). The data showed an unstable decreasing trend for three Joinpoints (August 2020, December 2020, and August 2021). Notably, a decrease in the incidence trend was observed from May 2019 to August 2020 (MPC, -4.1; 95% CI: -7.6, -0.5; P = 0.03), followed by a sharp increase (MPC, 23.7; 95% CI: -13.8, 77.7; P = 0.24) from August 2020 to December 2020. From December 2020 to August 2021, there was again a decreasing trend (MPC, -13.8; 95% CI: -23.3, -3.5; P = 0.01), followed by a slight increase from August 2021 to April 2022 (MPC, 4.2; 95% CI: -8.4, 18.6; P = 0.52). Finally, the study revealed an association between patterns of neonatal sepsis incidence trends and COVID-19, with a Joinpoint jump model comparability ratio (CR = 0.43) between pre- and COVID-19-impacted periods. Conclusions Neonatal sepsis was prevalent at Jimma Medical Center, but it was on an unstably declining trend. The current results suggest a potential temporal association between the intensity of COVID-19 containment measures and a change in the incidence trend and patterns of neonatal sepsis. However, the quantified contribution of a particular containment measure requires further investigation.

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Section: Plos Onementioning

confidence: 52%

Epidemiologic features of neonatal sepsis and its COVID-19 associated temporal patterns in Jimma Medical Center, Ethiopia: A Joinpoint regression analysis

Geleta,

Abebe,

Workneh

et al. 2023

PLoS ONE

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“…The relative variation in the prevalence of neonatal sepsis between our study and other studies could largely be attributable to differences in study design and period of review. For instance, while some studies have applied a case-control design [ 21 ] others were based on cohort analysis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Neonatal sepsis in a tertiary health facility in Cape Coast, Ghana

Craymah,

Tuoyire,

Adjei-Ofori

et al. 2024

PLoS ONE

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Background Neonatal Sepsis remains a significant burden globally, accounting for over 2.5 million neonatal deaths annually, with low-and middle-income countries (LMIC) including Ghana disproportionately affected. The current study sought to ascertain the prevalence of neonatal sepsis and associated factors based on analysis of institutional records from Cape Coast Teaching Hospital (CCTH) in Ghana. Methods The study involved a retrospective cross-sectional review of randomly sampled medical records of 360 neonates CCTH from January 2018 to December 2021. Descriptive proportions and binary logistic regression analysis were conducted to estimate the prevalence of neonates with sepsis and associated factors. Results The prevalence of neonates with sepsis over the period was estimated to be 59%, with early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS) accounting for about 29% and 30%, respectively. Neonatal factors associated with sepsis were low Apgar score (AOR = 1.64; 95% CI:1.01–2.67, p = 0.047) and low birth weight (AOR = 2.54; 95% CI:1.06–6.09, p = 0.037), while maternal factors were maternal education (AOR = 2.65; 95% CI:1.04–6.7, p = 0.040), caesarean deliveries (AOR = 0.45; 95% CI:0.26–0.75, p = 0.003), maternal infection (AOR = 1.79; 95% CI:1.09–2.94, p = 0.020) and foul-smelling liquor (AOR = 1.84; 95% CI:1.09–3.07, p = 0.020). Conclusion The study underscores the need for improved routine care and assessment of newborns to prevent the onset of neonatal sepsis, with particular emphasis on the neonatal and maternal risk factors highlighted in the current study.

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Temporal trend in early sepsis in a very low birth weight infants' cohort: an opportunity for a rational antimicrobial use

Cited by 2 publications

References 24 publications

Epidemiologic features of neonatal sepsis and its COVID-19 associated temporal patterns in Jimma Medical Center, Ethiopia: A Joinpoint regression analysis

Epidemiologic features of neonatal sepsis and its COVID-19 associated temporal patterns in Jimma Medical Center, Ethiopia: A Joinpoint regression analysis

Neonatal sepsis in a tertiary health facility in Cape Coast, Ghana

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