Temporal Summation of Pain Evoked by Mechanical Stimulation in Deep and Superficial Tissue

Nie, HongLing; Arendt-Nielsen, Lars; Andersen, Helle; Graven‐Nielsen, Thomas

doi:10.1016/j.jpain.2005.01.352

Cited by 150 publications

(136 citation statements)

References 39 publications

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“…This is in accordance with findings in other human studies, where deep pain acti- All parameters were unaffected vated central mechanisms (involving the NMDA receptor) more quickly than superficial pain [67]. Generally, models involving hyperalgesia induce longlasting and strong pain and therefore could demonstrate analgesia from ketamine.…”

Section: Mechanistic Aspectssupporting

confidence: 92%

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

Staahl

Olesen

Arendt‐Nielsen

et al. 2009

Brit J Clinical Pharma

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AIMExperimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODSA literature search was completed for randomized controlled studies that included human experimental pain models, healthy volunteers and non-opioid analgesics. RESULTSNonsteroidal anti-inflammatory drugs worked against various types of acute pain as well as in hyperalgesia. Analgesia from paracetamol was difficult to detect in experimental pain and the pain needed to be assessed with very sensitive methods like evoked brain potentials. The N-methyl-D-aspartate antagonists exemplified by ketamine generally needed strong, long-lasting or repeated pain in the skin for detectable analgesia, whereas pain in muscle and viscera generally was more easily attenuated. Gabapentin worked well in several models, particularly those inducing hyperalgesia, whereas lamotrigine was weak in modulation of experimental pain. Imipramine attenuated pain in most experimental models, whereas amitriptyline had weaker effects. Delta-9-tetrahydrocannabinol attenuated pain in only a few models.

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Section: Mechanistic Aspectssupporting

confidence: 92%

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

Staahl

Olesen

Arendt‐Nielsen

et al. 2009

Brit J Clinical Pharma

Self Cite

View full text Add to dashboard Cite

show abstract

“…Apparently, deep muscular or visceral pain is treated more successfully than superficial pain [4,31] . This supports the findings in other human studies in which deep pain activates central mechanisms (involving the NMDA receptor) such as summation more quickly than superficial pain does [32] . Hyperalgesia to electrical pain has been induced in the esophagus by acid infusion.…”

Section: N-methyl-d-aspartic Acid (Nmda)-antagonistssupporting

confidence: 91%

Translational pain research: Evaluating analgesic effect in experimental visceral pain models

Olesen¹,

Christrup²,

Upton³

2009

WJG

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“…Repeated tapping on a muscle by a pressure probe has recently been used to assess the efficacy of temporal summation, and temporal summation was found to be more potent for deep tissue stimulation compared with skin stimulation. 43 The facilitated degree of temporal summation indicates an enhanced central integrative mechanism (central sensitization). Therefore, facilitated temporal summation of pain in fibromyalgia and OA pain patients might suggest the involvement of central sensitization.…”

mentioning

confidence: 99%

Basic aspects of musculoskeletal pain: from acute to chronic pain

Arendt-Nielsen

Fernández‐de‐las‐Peñas

Graven‐Nielsen

2011

Journal of Manual & Manipulative Therapy

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128

104

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The transition from acute to chronic musculoskeletal pain is not well understood. To understand this transition, it is important to know how peripheral and central sensitization are manifested and how they can be assessed. A variety of human pain biomarkers have been developed to quantify localized and widespread musculoskeletal pain. In addition, human surrogate models may be used to induce sensitization in otherwise healthy volunteers. Pain can arise from different musculoskeletal structures (e.g. muscles, joints, ligaments, or tendons), and differentiating the origin of pain from those different structures is a challenge. Tissue specific pain biomarkers can be used to tease these different aspects. Chronic musculoskeletal pain patients in general show signs of local/central sensitization and spread of pain to degrees which correlate to pain intensity and duration. From a management perspective, it is therefore highly important to reduce pain intensity and try to minimize the duration of pain.

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Temporal Summation of Pain Evoked by Mechanical Stimulation in Deep and Superficial Tissue

Cited by 150 publications

References 39 publications

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

Translational pain research: Evaluating analgesic effect in experimental visceral pain models

Basic aspects of musculoskeletal pain: from acute to chronic pain

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