Temporal response patterns of single auditory nerve fibers elicited by periodic electrical stimuli

Honert, Chris van den; Stypulkowski, Paul H.

doi:10.1016/0378-5955(87)90168-7

Cited by 130 publications

(56 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the period histograms of Figures 1 and 2 show that spikes occur over narrower ranges within the modulation period as the fiber adapts across time. This contrasts with the observations using electric sinusoidal stimuli in which the spike distribution with the sinusoidal period widened as stimulus level was decreased (van den Honert and Stypulkowski 1987b). One likely reason for this difference is our use of partial (10%) amplitude modulation of the carrier.…”

Section: Modulation Coding By Anfs: Effects Of Level and Stimulus Durcontrasting

confidence: 66%

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Miller

Abbas

et al. 2010

JARO

View full text Add to dashboard Cite

Response rates of auditory nerve fibers (ANFs) to electric pulse trains change over time, reflecting substantial spike-rate adaptation that depends on stimulus parameters. We hypothesize that adaptation affects the representation of amplitude-modulated pulse trains used by cochlear prostheses to transmit speech information to the auditory system. We recorded cat ANF responses to sinusoidally amplitude-modulated (SAM) trains with 5,000 pulse/s carriers. Stimuli delivered by a monopolar intracochlear electrode had fixed modulation frequency (100 Hz) and depth (10%). ANF responses were assessed by spike-rate measures, while representation of modulation was evaluated by vector strength (VS) and the fundamental component of the fast Fourier transform (F 0 amplitude). These measures were assessed across the 400 ms duration of pulse-train stimuli, a duration relevant to speech stimuli. Different stimulus levels were explored and responses were categorized into four spike-rate groups to assess level effects across ANFs. The temporal pattern of rate adaptation to modulated trains was similar to that of unmodulated trains, but with less rate adaptation. VS to the modulator increased over time and tended to saturate at lower spike rates, while F 0 amplitude typically decreased over time for low driven rates and increased for higher driven rates. VS at moderate and high spike rates and degree of F 0 amplitude temporal changes at low and moderate spike rates were positively correlated with the degree of rate adaptation. Thus, high-rate carriers will modify the ANF representation of the modulator over time. As the VS and F 0 measures were sensitive to adaptation-related changes over different spike-rate ranges, there is value in assessing both measures.

show abstract

Section: Modulation Coding By Anfs: Effects Of Level and Stimulus Durcontrasting

confidence: 66%

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Miller

Abbas

et al. 2010

JARO

View full text Add to dashboard Cite

show abstract

“…We note, however, that in 2 of 6 fibers of Figure 4, initial (1-ms window) rates were greater than 1000 spike/s, as two spikes were often registered within a single bin. Relatively high onset rates with electric stimuli are consistent with the observation that, when compared with acoustic stimuli, electric stimuli can transiently drive fibers to respond with short ISIs, i.e., more effectively drive fibers out of states of partial refractoriness (van den Honert and Stypulkowski 1987b;Miller et al 2001). Comparisons of onset rates obtained across studies that used different bin widths are problematic.…”

Section: Fig 13mentioning

confidence: 72%

Changes Across Time in Spike Rate and Spike Amplitude of Auditory Nerve Fibers Stimulated by Electric Pulse Trains

Zhang

Miller

Robinson

et al. 2007

JARO

143

View full text Add to dashboard Cite

We undertook a systematic evaluation of spike rates and spike amplitudes of auditory nerve fiber (ANF) responses to trains of electric current pulses. Measures were obtained from acutely deafened cats to examine time-related changes free from the effects of hair-cell and synaptic adaptation. Such data relate to adaptation that likely occurs in ANFs of cochlear-implant users. A major goal was to determine and compare rate adaptation observed at different pulse rates (primarily 250, 1000, and 5000 pulse/s) and describe them using decaying exponential models similar to those used in acoustic studies. Rate-vs.-time functions were best described by two-exponent models and produced time constants similar to (although slightly greater than) the Brapid^and Bshort-term^components described in acoustic studies. There was little dependence of these time constants on onset spike rate, but pulse-rate effects were noted. Spike amplitude changes followed a time course different from that of rate adaptation consistent with a process related to ANF interspike intervals. The fact that two time constants governed rate adaptation in electrically stimulated and deafened fibers suggests that future computational models of adaptation should not only include hair cell and synapse components, but also components determined by fiber membrane characteristics.

show abstract

“…In contrast, frequency-modulation discrimination using a high modulation rate of 10 Hz, in which phase-locking cues are considered less useful (because of the short time the stimulus spends at the frequency extremes), does follow the predictions of models based on excitation patterns. Given that electrophysiological experiments show a higher degree of phase-locking of auditory nerve fibers to electrical stimulation than occurs with acoustic stimulation (Hartmann and Klinke, 1990;Javel, 1990;van den Honert and Stypulkowski, 1987), it is perhaps surprising that there is no evidence that implantees can use phase locking cues above several hundred Hertz. It is possible that implantees have a limitation in their temporal discrimination that is additional to that in normally hearing listeners.…”

Section: Introductionmentioning

confidence: 99%

Place and temporal cues in pitch perception: are they truly independent?

McKay

McDermott

Carlyon

2000

Acoustics Research Letters Online

View full text Add to dashboard Cite

Four adult users of the Mini System 22 cochlear implant participated in an experiment to investigate the perceptual independence of place-of-stimulation and temporal cues for pulsatile electrical stimulation. The motivation was the relatively poor rate discrimination ability of cochlear implantees compared to the higher accuracy of temporal coding revealed by electrophysiological measurements and the performance of normal hearing listeners. The hypothesis tested was that the central auditory system can combine consistent rate and place cues in a way that is more effective than using each cue independently. Difference limens for rate change, place change, and combined rate and place change (with consistent and inconsistent cues) were compared for stimulation at low and high rates. The results were compatible with place and rate cues being used independently in the combined rate-and place-change conditions, with no advantage found for the consistent-cue conditions.

show abstract

Temporal response patterns of single auditory nerve fibers elicited by periodic electrical stimuli

Cited by 130 publications

References 23 publications

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Changes in Auditory Nerve Responses Across the Duration of Sinusoidally Amplitude-Modulated Electric Pulse-Train Stimuli

Changes Across Time in Spike Rate and Spike Amplitude of Auditory Nerve Fibers Stimulated by Electric Pulse Trains

Place and temporal cues in pitch perception: are they truly independent?

Contact Info

Product

Resources

About