Temporal relationship between hyperuricemia and obesity, and its association with future risk of type 2 diabetes

Han, Tianshu; Meng, Xiangyi; Shan, Ruiqi; Zi, Tianqi; Li, Yingmei; Ma, Hao; Zhao, Yunmeng; Shi, Dan; Qu, Rongge; Guo, Xiaoyu; Liu, Lei; Na, Lixin; Liu, Ying; Sun, Changhao

doi:10.1038/s41366-018-0074-5

Cited by 61 publications

(67 citation statements)

References 37 publications

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“…We observed that SUA was higher in T2DM patients with overweight/obesity group than in those with normal weight group, SUA within normal range independently related to obesity in T2DM. Consistent with our results, several previous studies have also shown the relationship between BMI and uric acid (Han et al 2018). For example, Chen et al (Chen et al 2017) also found that prevalence of obesity steadily increased across SUA quartiles in T2DM.…”

Section: Discussionsupporting

confidence: 93%

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

2019

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Background: Elevated serum uric acid (SUA) has a positive correlation with insulin secretion and insulin resistance indexes. However, whether weight-and gender-specific differences regarding the relationship between SUA within the normal range and β-cell function and insulin resistance exist is unknown in T2DM patients. Methods: Three hundreds and eighty patients with type 2 diabetes were divided into two groups as overweight/obesity (n=268) and normal weight (n=112). Each group were again divided into low (LSUA) and high normal SUA (HSUA). The HbA1c, C-peptide, SUA, creatinine, and lipids profiles were measured. HOMA2IR and HOMA%2B were estimated using fasting glucose and C-peptide by homeostasis model assessment (HOMA). Pearson's correlations and multiple linear regression analyses were conducted to assess the associations between SUA levels and islet function indexes. Results: In overweight/obesity subgroup, the levels of BMI, FCP, P2HCP, FCPI, PPCPI, ΔC-peptide, HOMA2%B and HOMA2IR were higher in HSUA group than in LSUA group. In contrast, the HbA1c, FBS, and P2hBS were lower in HSUA than in LSUA. In normal weight subgroup, there were on differences between the HSUA than LSUA group in terms of clinical characteristics. Pearson's correlations indicated that there were no significant correlations between SUA and insulin secretory capacity in normal weight group, but in overweight/obesity group, SUA had positive significant correlations with P2hCP, FCPI, PPCPI, ΔC-peptide, and HOMA2%B. In female group, there were no significant correlations between SUA and insulin secretory capacity. However, in male group, SUA had positive significant correlations with insulin secretory capacity include P2hCP, FCPI, PPCPI, ΔC-peptide, and HOMA2%B. Multiple linear regression showed that SUA was significantly associated with HOMA2%B, but not with HOMA2IR in overweight/obesity and male group. Conclusions : Our study shows that SUA levels within normal range were associated with β-cell function in T2DM patients with overweight/obesity or male. This finding supports that the association between SUA within normal range and insulin secretion ability differs by weight and sex.

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Section: Discussionsupporting

confidence: 93%

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

2019

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“…Our results are consistent with those of recent studies from Japan [30][31][32] . Evidence from these studies showed that visceral fat area is significantly related to SUA level.…”

Section: Risk Factors Of Huasupporting

confidence: 94%

Correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes

Zong

Sun

Zhang

et al. 2020

Preprint

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Background The aim of this study was to investigate the correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes (T2DM).Methods A total of 867 patients with T2DM were enrolled. Measurements of central fat distribution were obtained by dual energy X-ray absorptiometry. Patients were stratified into three groups according to their levels of serum uric acid (SUA). Multiple linear regression analysis was used to determine the association between SUA and central body fat distribution. Logistic regression analysis was used to estimate the risk factors for hyperuricemia (HUA). Mediation analysis was applied to assess the overall, direct, and indirect mediators of SUA levels.Results Multiple linear regression analysis showed that SUA levels were significantly positively correlated with waist circumference (WC), body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue(SAT), Android fat mass, Gynoid fat mass, fasting c-peptide (F-CP), and area under the curve of C-peptide (P < 0.05 for all). VAT [odds ratio (OR), 2.367; 95% confidence interval (CI), 1.078–5.197; P < 0.001)], WC (OR, 1.041; 95% CI, 1.011–1.072; P < 0.001), high-density lipoprotein (OR, 0.274; 95% CI, 0.104–0.727; P < 0.001), and estimated glomerular filtration rate (OR, 0.966; 95% CI, 0.959–0.973; P < 0.001) were found to be independent risk factors for T2DM patients with HUA. After mediation analysis, BMI and central obesity were found to have different partial effects on the association between SUA and F-CP (P < 0.001).Conclusions In patients with T2DM, HUA was positively correlated with F-CP and central body fat distribution, especially VAT. These results suggest that central obesity may play a role in the positive correlation between HUA and insulin resistance (IR).

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“…Our results are consistent with those of recent studies from Japan. [33][34][35] Evidence from these studies showed that visceral fat area is significantly related to SUA level. Upon reduction of VAT, SUA levels significantly declined.…”

Section: Risk Factors Of Huamentioning

confidence: 99%

<p>Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes</p>

Zong

Sun

Zhang

et al. 2020

DMSO

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Background: The aim of this study was to investigate the correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes (T2DM). Methods: A total of 867 patients with T2DM were enrolled. Measurements of central fat distribution were obtained by dual energy X-ray absorptiometry. Patients were stratified into three groups according to their levels of serum uric acid (SUA). Multiple linear regression analysis was used to determine the association between SUA and central body fat distribution. Logistic regression analysis was used to estimate the risk factors for hyperuricemia (HUA). Mediation analysis was applied to assess the overall, direct, and indirect mediators of SUA levels. Results: Multiple linear regression analysis showed that SUA levels were significantly positively correlated with waist circumference (WC), body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), Android fat mass, Gynoid fat mass, fasting c-peptide (F-CP), and area under the curve of C-peptide (P < 0.05 for all). VAT [odds ratio (OR), 2.367; 95% confidence interval (CI), 1.078-5.197; P < 0.001)], WC (OR, 1.041; 95% CI, 1.011-1.072; P < 0.001), high-density lipoprotein (OR, 0.274; 95% CI, 0.104-0.727; P < 0.001), and estimated glomerular filtration rate (OR, 0.966; 95% CI, 0.959-0.973; P < 0.001) were found to be independent risk factors for T2DM patients with HUA. After mediation analysis, BMI and central obesity were found to have different partial effects on the association between SUA and F-CP (P < 0.001). Conclusion: In patients with T2DM, HUA was positively correlated with F-CP and central body fat distribution, especially VAT. These results suggest that central obesity may play a role in the positive correlation between HUA and insulin resistance (IR).

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Temporal relationship between hyperuricemia and obesity, and its association with future risk of type 2 diabetes

Abstract: These findings indicated that increased uric acid levels probably associated with obesity and type 2 diabetes, and more definite research is needed to define any role for uric acid in relation to these diseases.

Cited by 61 publications

References 37 publications

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

Peer Review #1 of "The relationship between serum uric acid within the normal range and β-cell function in Chinese patients with type 2 diabetes: differences by body mass index and gender (v0.1)"

Correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes

<p>Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes</p>

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