Temporal Relation between Macular Ganglion Cell–Inner Plexiform Layer Loss and Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma

Kim, Young Kook; Ha, Ahnul; Na, Kyeong Ik; Kim, Hae Jin; Jeoung, Jin Wook; Park, Ki Ho

doi:10.1016/j.ophtha.2017.03.014

Cited by 72 publications

(65 citation statements)

References 32 publications

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“…To date, only a few studies have assessed the agreement of progression between the RNFL and GCIPL . Shin et al reported that GCIPL progression assessment by using OCT‐GPA would provide more information than would RNFL progression assessment in advanced‐stage glaucoma.…”

Section: Discussionmentioning

confidence: 99%

“…Shin et al reported that GCIPL progression assessment by using OCT‐GPA would provide more information than would RNFL progression assessment in advanced‐stage glaucoma. In another study, Kim et al evaluated the temporal relationship between RNFL and GCIPL progression by comparing OCT deviation maps and reported that GCIPL changes were frequently detected before corresponding RNFL changes, especially in the early stage of glaucoma. These findings suggest the presence of disagreement in RNFL and GCIPL progression.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell‐inner plexiform layers determined using optical coherence tomography‐guided progression analysis

Hwang

Kim

Chung

et al. 2018

Clinical and Experimental Optometry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell‐inner plexiform layers determined using optical coherence tomography‐guided progression analysis

Hwang

Kim

Chung

et al. 2018

Clinical and Experimental Optometry

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“…Thus, studies have been gradually highlighting the importance of scrutinising the damage in the MVZ of the optic disc and corresponding macular areas for diagnosis and detection of glaucoma progression 1 48–50. Kim et al 51 recently reported the temporal relationship between RNFL and GCIPL loss based on OCT deviation maps. Their results showed that in early-glaucoma eyes, macular GCIPL change was frequently detected earlier than corresponding RNFL change (figure 3), in line with their previous findings 48.…”

Section: Introductionmentioning

confidence: 99%

“…(H) The integrated deviation map for year 2015 shows the subsequent emergence of pRNFL defect (red arrowhead) in the macular vulnerability zone (MVZ) 1. (J) Schematic representation of both inferoinferior and MVZ–pRNFL defects in eye showing inferior mGCIPL loss (adapted from Kim et al 51). …”

Section: Introductionmentioning

confidence: 99%

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

Kim

Park

2017

Br J Ophthalmol

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The macular area is important to the detection of glaucomatous retinal ganglion cell (RGC) damage. Macular thickness complementary to peripapillary retinal nerve fibre layer (RNFL) thickness can well reflect glaucomatous damage, given that the macula contains more than 50% of the RGCs in a multilayered pattern and larger RGC bodies compared with their axons. Thus, macular ganglion cell thickness parameters recently have been considered to be an effective glaucoma-diagnostic tool comparable to RNFL thickness parameters. Furthermore, spectral-domain optical coherence tomography ganglion cell-inner plexiform layer thickness and deviation maps can provide additional information essential for distinguishing glaucomatous changes from other, myopia-associated or macular disease-associated changes. Therefore, our aim with this study was to review the clinical application of macular imaging by optical coherence tomography and to provide essential clinical tips for its use in the diagnosis and management of glaucoma.

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“…[7][8][9][10][11][12][13][14][15] Furthermore, studies using spectral-domain optical coherence tomography (SD-OCT) have shown that macular damage in early glaucoma is much more common than previously thought and is often present in eyes with 24-2 mean deviation (MD) better (ie, closer to 0) than −6 dB. [16][17][18][19][20] Because of their importance in clinical and research settings, and given their substantial association with measures of vision-related quality of life, 21,22 24-2 (or 30-2) SAP metrics have traditionally been used to stage glaucoma severity. 23 Although some of these staging systems take into account the presence of central field damage as a sign of more severe disease, 24,25 an important caveat they all share is the lack of a finer assessment of macular damage, whether by means of incorporating 10-2 fields or SD-OCT macular scans.…”

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confidence: 99%

Association of Macular Visual Field Measurements With Glaucoma Staging Systems

et al. 2019

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IMPORTANCE Macular function is important for daily activities but is underestimated when tested with 24-2 visual fields, which are often used to classify glaucoma severity.OBJECTIVE To test the hypothesis that current glaucoma staging systems underestimate glaucoma severity by not detecting macular damage. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional study was carried out in a glaucoma referral practice. The eyes of participants with manifest glaucoma and 24-2 mean deviation (MD) better than −6 dB were included. All participants were tested with 24-2, 10-2 visual fields, and spectral-domain optical coherence tomography of the optic disc and macula.EXPOSURES Macular damage was based on the topographic agreement between visual field results and retinal ganglion cell plus inner plexiform layer probability plots. Classifications from the Hodapp-Parrish-Anderson (HPA), visual field index (VFI), and Brusini staging systems were examined and compared with visual field and spectral-domain optical coherence tomography results. MAIN OUTCOMES AND MEASURESThe association between the presence of macular damage and glaucoma severity scores.RESULTS Fifty-seven eyes of 57 participants were included; 33 participants (57%) were women, and 43 (75%) were white. Their mean (SD) age was 57 ( 14) years. Forty-eight of the eyes (84% [95% CI, 72%-92%]) had macular damage by the study definition. These had a 24-2 MD mean (SD) of −2.5 (1.8); corresponding results for the 10-2 MD were −3.0 (2.4) dB and for the VFI were 94.2% (4.5%). The HPA system classified 70% (95% CI, 55%-83%) of eyes with macular damage as having early defects; the VFI system classified 81% (95% CI, 67%-91%) of eyes with macular damage as having early defects, and the Brusini system 68% (95% CI, 53%-81%).CONCLUSIONS AND RELEVANCE These findings suggest that current glaucoma staging systems based on 24-2 (or 30-2) visual fields underestimate disease severity and the presence of macular damage. If these results are confirmed and generalizable to other participants, new systems using macular measures (from 10-2 and spectral-domain optical coherence tomography results) might improve staging of glaucoma severity.

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Temporal Relation between Macular Ganglion Cell–Inner Plexiform Layer Loss and Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma

Cited by 72 publications

References 32 publications

Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell‐inner plexiform layers determined using optical coherence tomography‐guided progression analysis

Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell‐inner plexiform layers determined using optical coherence tomography‐guided progression analysis

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

Association of Macular Visual Field Measurements With Glaucoma Staging Systems

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