Temporal recovery of auditory evoked potentials in individuals at risk for alcoholism

Cohen, Herbert J.; Porjesz, Bernice; Begleiter, Henri

doi:10.1016/0741-8329(96)00003-1

Cited by 4 publications

(3 citation statements)

References 43 publications

(67 reference statements)

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“…Olbrich et al (2000) reported reduced N1 amplitude at lead Cz. In the auditory domain, some authors reported enhanced auditory N1 in abstinent alcoholics (Ahveninen et al, 2000), whereas no such effect was reported by most (Cohen et al, 1996(Cohen et al, , 2002Olbrich et al, 2000;Patterson et al, 1987;Pfefferbaum et al, 1979). Overall, these findings suggest a modality specificity of the effect of alcoholism on the N1.…”

Section: Discussionmentioning

confidence: 50%

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Heritability of anterior and posterior visual N1

Smit

Posthuma

Boomsma

et al. 2007

International Journal of Psychophysiology

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Section: Discussionmentioning

confidence: 50%

“…history of alcoholism did not show affected N1 amplitude (Cohen et al, 1996), and normal N1 amplitudes were obtained before alcohol ingestion (Porjesz and Begleiter, 1990;Porjesz et al, 2005). Strong trends towards reduced amplitude in people with a family history of alcoholism were found for visual and auditory N1 by Patterson et al (1987).…”

Section: Discussionmentioning

confidence: 90%

Heritability of anterior and posterior visual N1

Smit

Posthuma

Boomsma

et al. 2007

International Journal of Psychophysiology

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“…Using a bimodal task (auditory and visual stimuli), a study on abstinent alcoholics, controls, and FHP offspring showed reduced visual N1 amplitude in alcoholics and reduced auditory N1 amplitude in the FHP individuals (Patterson et al, 1987). The dampening of N1 amplitudes to repetitive stimuli may be associated with the refractoriness (Cohen et al, 1996) or may be a reflection of lateral inhibition at the cortical level (Sable et al, 2004); however they were not very effective in differentiating HR from LR individuals.…”

Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.

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Frontal Lobe Changes in Alcoholism: A Review of the Literature

Moselhy

Georgiou²,

Kahn³

2001

Alcohol and Alcoholism

478

321

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Alcohol can induce a wide spectrum of effects on the central nervous system. These effects can be recognized at the neurophysiological, morphological and neuropsychological levels. Several studies of the effect of alcohol on the frontal lobes were identified for review from MedLine, PsychLIT databases and by manual searching. In this review article, the different changes are examined in detail. Computed tomography studies have reported changes of frontal lobe in alcoholism, while magnetic resonance imaging studies supported these findings. Neurophysiological studies with positron emission tomography and single photon emission computed tomography have reported a decreased frontal lobe glucose utilization and reduced cerebral blood flow. There is also evidence from neuropsychological studies that there are specific deficits in alcoholism that suggest frontal lobe dysfunction. Considered together, these studies lend a strong credence to the concept of frontal lobe pathology in alcoholism. However, frontal lobe is not an isolated part of the brain and should be considered with its heavy connections to different cortical and subcortical areas of the brain.

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Temporal recovery of auditory evoked potentials in individuals at risk for alcoholism

Cited by 4 publications

References 43 publications

Heritability of anterior and posterior visual N1

Heritability of anterior and posterior visual N1

Understanding alcohol use disorders with neuroelectrophysiology

Frontal Lobe Changes in Alcoholism: A Review of the Literature

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