Temporal progression of hypothalamic patterning by a dual action of BMP

Ohyama, Katsumi; Das, Raman M; Placzek, Marysia

doi:10.1242/dev.027078

Cited by 50 publications

(50 citation statements)

References 44 publications

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“…Therefore, one interpretation may be that BMP4 treatment during the early differentiation stage in our culture prevents hESC-derived forebrain neuroepithelium from adopting the telencephalic fate and redirects it into retinal progenitors. In the early embryo, BMP signals are expressed near the anterior neural ridge and in the prechordal mesoderm, and are implicated in the patterning of rostral diencephalon of the early embryo 65 , including hypothalamic (diencephalic) induction 66,67 .…”

Section: Discussionmentioning

confidence: 99%

Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

et al. 2015

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In the developing neural retina (NR), multipotent stem cells within the ciliary margin (CM) contribute to de novo retinal tissue growth. We recently reported the ability of human embryonic stem cells (hESCs) to self-organize stratified NR using a three-dimensional culture technique. Here we report the emergence of CM-like stem cell niches within human retinal tissue. First, we developed a culture method for selective NR differentiation by timed BMP4 treatment. We then found that inhibiting GSK3 and FGFR induced the transition from NR tissue to retinal pigment epithelium (RPE), and that removing this inhibition facilitated the reversion of this RPE-like tissue back to the NR fate. This step-wise induction-reversal method generated tissue aggregates with RPE at the margin of central-peripherally polarized NR. We demonstrate that the NR-RPE boundary tissue further self-organizes a niche for CM stem cells that functions to expand the NR peripherally by de novo progenitor generation.

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Section: Discussionmentioning

confidence: 99%

Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

et al. 2015

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“…The enhanced activation of Smad1 signaling is predicted to participate in neuronal differentiation of p53 -/ -NSCs, as BMPs (the main activator of Smad1/5/8) are known to regulate neurogenesis in cell context, localization, and stage- dependent manners [9,[38][39][40]. To determine the function of BMPs in NSCs, we treated WT and p53 -/ -NSCs with 50 ng/ mL of BMP2, which led to an increase in Smad1/5/8 phosphorylation ( Supplementary Fig.…”

Section: P53mentioning

confidence: 99%

p53 Regulates Neural Stem Cell Proliferation and Differentiation via BMP-Smad1 Signaling and Id1

Liu

Jia²,

Li³

et al. 2013

Stem Cells and Development

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“…Wnt signaling also governs regionalization of the nascent hypothalamus, directing the emergence of posterior (mamillary) hypothalamus throughout development, Shh and multiple different bone morphogenetic proteins (BMPs) show dynamic spatio-temporal profiles. Expression of Shh and Shh signaling components is negatively regulated by BMP signaling (Manning et al, 2006;Ohyama et al, 2008). Studies in the limb bud show that cross talk between the BMP and Shh pathways is critical for integrated growth, pattern, and differentiation (Bénazet et al, 2009), and raises the possibility that a similar cross talk between BMP and Shh signaling regulates proliferation and spatial patterning of hypothalamic neural progenitors in a concerted manner.…”

Section: Patterning Of Developing Thalamus and Hypothalamus By Secretmentioning

confidence: 99%

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

et al. 2010

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The embryonic diencephalon gives rise to the vertebrate thalamus and hypothalamus, which play essential roles in sensory information processing and control of physiological homeostasis and behavior, respectively. In this review, we present new steps toward characterizing the molecular pathways that control development of these structures, based on findings in a variety of model organisms. We highlight advances in understanding how early regional patterning is orchestrated through the action of secreted signaling molecules such as Sonic hedgehog and fibroblast growth factors. We address the role of individual transcription factors in control of the regional identity and neural differentiation within the developing diencephalon, emphasizing the contribution of recent large-scale gene expression studies in providing an extensive catalog of candidate regulators of hypothalamic neural cell fate specification. Finally, we evaluate the molecular mechanisms involved in the experience-dependent development of both thalamo-cortical and hypothalamic neural circuitry. IntroductionThe developing vertebrate forebrain consists of two major parts: the telencephalon-which gives rise to cerebral cortex, striatum, amygdala, and associated structures-and the diencephalon. The diencephalon gives rise to two essential brain regions, the thalamus and hypothalamus (Fig. 1 A). Though both structures are derived from a common region of the anterior neural tube, they serve very different physiological functions. The thalamus acts as a central integrator of sensory information, receiving afferents from receptors of all sensory modalities save olfaction, and serves as the sole path by which integrated sensory information reaches the cerebral cortex and gives rise to conscious perception. The hypothalamus, on the other hand, serves a more diverse range of functions. It is a central regulator of critical homeostatic physiological processes, including temperature regulation, food intake,

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Temporal progression of hypothalamic patterning by a dual action of BMP

Cited by 50 publications

References 44 publications

Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

p53 Regulates Neural Stem Cell Proliferation and Differentiation via BMP-Smad1 Signaling and Id1

Molecular Pathways Controlling Development of Thalamus and Hypothalamus: From Neural Specification to Circuit Formation

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