2010
DOI: 10.1016/j.brainres.2010.04.077
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Temporal processing in inferior colliculus and auditory cortex affected by high doses of salicylate

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Cited by 16 publications
(14 citation statements)
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“…The neural hyperactivity and frequency map reorganization that occurs in the central auditory center after treatment with high dose SS have been documented previously (Chen and Jastreboff, 1995; Chen et al, 2012, 2013, 2014a, 2014b; Deng et al, 2010; Lu et al, 2011; Norena et al, 2010; Stolzberg et al, 2011b; Sun et al, 2009; Zhang et al, 2011). However, the neural origins of these phenomena and the extent to which more peripheral structures such as the CN and IC contribute to these changes are poorly understood.…”
Section: Discussionsupporting
confidence: 57%
“…The neural hyperactivity and frequency map reorganization that occurs in the central auditory center after treatment with high dose SS have been documented previously (Chen and Jastreboff, 1995; Chen et al, 2012, 2013, 2014a, 2014b; Deng et al, 2010; Lu et al, 2011; Norena et al, 2010; Stolzberg et al, 2011b; Sun et al, 2009; Zhang et al, 2011). However, the neural origins of these phenomena and the extent to which more peripheral structures such as the CN and IC contribute to these changes are poorly understood.…”
Section: Discussionsupporting
confidence: 57%
“…For example, enhanced driven neural activity is consistently observed across the tonotopic extent of the cortical surface even when salicylate is administered by different routes, such as systemically (Qiu et al, 2000; Yang et al, 2007; Sun et al, 2009a; Deng et al, 2010; Noreña et al, 2010; Lu et al, 2011; Zhang et al, 2011) (Figure 3), or directly to the cortical surface (Lu et al, 2011)—the latter approach being unlikely to bring about changes within the cochlea itself. The likelihood that this stably inducible effect is mediated via a suppression of GABAergic signaling efficacy is strongly suggested by the absence of any such enhancement when agents that positively modulate GABA pharmacology were coadministered (Sun et al, 2009a; Lu et al, 2011).…”
Section: Neuronal Spontaneous and Evoked Response Properties Undergo mentioning
confidence: 99%
“…In these experiments, recorded units displayed substantially broadened bandwidths, implying that a large degree of their sensitivity to pre-exposure CFs was presumably retained (Stolzberg et al, 2011). It is also rather striking that both salicylate exposure (Deng et al, 2010) and acoustic trauma (Yin et al, 2008) each yield an apparently equivalent reduction in the cortical gap-detection threshold for stimulation off-channel, i.e., completely outside of the region displaying peripheral threshold elevation. This might suggest that each insult commonly disrupts a frequency-insensitive mechanism, or mechanisms, critical to the precise encoding of temporally salient information.…”
Section: Insult-mediated Changes In Neural Spectrotemporal Receptive mentioning
confidence: 99%
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“…Hearing loss can potentially affect the outcome of GPIAS screening in a number ways: by interfering with audibility of the background sound in which the silent gaps are imbedded or by altering the amplitude of the startle reflex to the startle stimulus alone (no-gap condition). Previous studies in both rodents (55) and humans (56) have demonstrated that hearing loss alone, induced by sodium salicylate exposure, can interfere in detection of gaps in low-level continuous noise. This issue has been addressed in the GPIAS paradigm by using intensities of background sounds (60 dB SPL) shown to be resilient to the effects of hearing loss, and by carrying out noise-burst pre-pulse detection measures.…”
Section: Animal Models Of Tinnitusmentioning
confidence: 99%