Temporal Pattern of CABG and PCI after Non-ST Elevation Myocardial Infarction Among Elderly Patients from NHDS.

Siddiqui, Muhammad Umer; Chiuzan, Codruța; Siddiqui, Muhammad Danial; Ali, Syed Atif; Naeem, Zunaira; Islam, Shariful

doi:10.7759/cureus.6814

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Acute coronary syndrome manifests in various forms, including unstable angina and myocardial infarction with or without ST-segment elevation. These manifestations stem from coronary artery disease and increase the risk of sudden death and heart attacks [1]. Revascularization and coronary artery bypass graft (CABG) surgery are standard selective treatments for coronary disease.s.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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Background: Bleeding is a significant complication of cardiac surgeries, leading to increased blood product utilization, higher rates of reoperation, and mortality. Tranexamic acid is one of the main medications used to control postoperative bleeding in these patients. Therefore, the aim of this study was to compare the effects of intravenous, topical, and oral tranexamic acid in reducing postoperative bleeding after coronary artery bypass grafting (CABG) surgery. Materials and methods: This clinical trial was conducted on 96 patients scheduled for CABG surgery. The patients were divided into three groups of 32, receiving oral, intravenous, and topical tranexamic acid. After the surgery and administration of the respective medication, the amount of bleeding within 72 hours postoperatively, as well as the amount of packed red blood cells, platelets, and fresh frozen plasma received within 24 hours postoperatively were assessed. Results:The mean age of the participating patients was 64±5.4 years, and the three groups did not significantly differ in terms of age, gender distribution, number of grafts (P=0.421), and duration of surgery (P=0.624). There was no significant difference in the bleeding score among the three groups, with scores of 3.9±0.88 in the intravenous group, 4.1±1.1 in the oral group, and 4.4±0.98 in the topical group (P=0.221). The average amount of packed red blood cells, platelets, and fresh frozen plasma received during and after surgery was similar in all three groups, with values of 2 (P=0.422), 3.5 (P=0.402), and 2.4 (P=0.412), respectively. Conclusion: In general, the results of this study indicate that the use of tranexamic acid in all three available forms (oral, intravenous, and topical) leads to a reduction in postoperative bleeding with similar outcomes. Therefore, concerning the fewer side effects of the topical and oral forms and their sufficient effectiveness, physicians can utilize these methods for prescribing tranexamic acid.

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Section: Introductionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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“…Acute coronary syndrome is still a serious challenge to the clinical practice [1] [2] [3] [4]. Each person experiences a coronary event every 40 seconds, which increases the number of recurrent myocardial infarction by more than 600,000 and 200,000 per year [5] [6].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Application of Fondaparinux in Acute Coronary Syndrome

Han¹,

Jin²

2020

CRCM

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Acute Coronary Syndrome (ACS) is one of the major causes of death worldwide, including unstable angina, ST-segment elevation myocardial infarction and NST-segment elevation myocardial infarction. ACS refers to a series of life-threatening heart diseases, which is caused by rupturing coronary plaque and releasing thrombin activation. Then thrombin is activated and generates plaque and thrombosis, which increases the risk of cardiac death and myocardial infarction. Aggressive and conservative treatment is available in clinic practice. Anticoagulant therapy is usually the first choice for conservative treatment and used in combination with dual antiplatelet drugs, which plays an important role in the treatment of acute coronary syndrome. Fondaparinux as a commonly used anticoagulant drug is both antithrombotic effectively and can reduce the risk of bleeding and coronary microvascular dysfunction in the pathogenesis of ischemic heart disease. However, it increased the rate of bleeding. People pay more attention to the role of long-term prognosis. Domestic and foreign researches contrast outcomes of acute coronary syndrome of fondaparinux and low molecular weight heparin.

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Physiological Impacts of Personal Protective Equipment on Health Care Workers

Arif

Bhatti

Hussain

et al. 2021

IJOSH

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Introduction: Since the outbreak of the Ebola virus, its design has constantly been evolving to serve the purpose of protection without hampering the efficiency. In a study conducted in 2019, before the advent of COVID 19, it was found that performing precarious laboratory or clinical works while wearing PPE involved various restrictions compared to the same work without PPE. The objective of this study is to identify the influence of personal protective equipment on physiological parameters and the individual wellbeing of healthy workers. Methods: This Pilot Quasi-experimental study was performed on 12 volunteers fitting the inclusion criteria. Candidates were seated comfortably and their baseline resting pulse rate, respiratory rate, oxygen saturation via pulse oximeter, blood pressure, and End-tidal CO2 were recorded via a portable monitor. All candidates were asked to wear a KN95 mask along with a 3 ply mask over it and wear anti-fog goggles. All the above-mentioned parameters were recorded again after five minutes of comfortable sitting and ten minutes of brisk walk. Result: Significant difference is found between resting EtCO2 and after wearing of PPE (P = 0 .044). After a brief exercise, the further rise in EtCO2 is also significant (P = 0.002). There is no significant rise in pulse after wearing PPE (P = 0.092) but on exertion after wearing PPE, the rise in pulse is statistically significant (P = 0.002). The rest of the variables, such as the rise in respiratory rate, blood pressure, and fall in oxygen saturation rise has no statistical significance. Conclusion: Personal protective equipment has proven to rise in end-tidal carbon dioxide and tachycardia, which can lead to headache, dizziness, and respiratory discomfort. All of the factors can hamper the health care workers' performance and can adversely affect their efficiency.Keywords: covid-19, end tidal CO2, personal protective equipment, physiological

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Temporal Pattern of CABG and PCI after Non-ST Elevation Myocardial Infarction Among Elderly Patients from NHDS.

Cited by 3 publications

References 14 publications

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Advances in the Application of Fondaparinux in Acute Coronary Syndrome

Physiological Impacts of Personal Protective Equipment on Health Care Workers

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