Temporal impacts of topical ceftazidime and tobramycin-vancomycin mixtures on the ocular surface microbiota in rabbits

Xue, Ran; Liu, Qinghua; Li, Jingwei; Jin-liang, Jiang; Zong, Yi; Liu, Xiuping; Wu, Kaili

doi:10.1016/j.exer.2022.109098

Cited by 1 publication

(1 citation statement)

References 53 publications

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“…As mentioned, some antibiotics can have a deep impact on the ocular microbiota and diversity. Recently, it was demonstrated that species diversity, community structure, and the composition of the ocular surface microbiota were significantly changed after exposure to ceftazidime or tobramicyn and vancomycin; however, they tended to be restored within weeks after discontinuing antibiotic treatment [29]. This aspect is managed well by other antibiotics if the right dosage of antibiotic is maintained and its administration is not prolonged beyond what is necessary.…”

Section: Optimizing Ocular Infection Treatment: Preserving the Ocular...mentioning

confidence: 99%

Topical Antibiotic Therapy in the Ocular Environment: The Benefits of Using Moxifloxacin Eyedrops

Drago

2024

Microorganisms

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Moxifloxacin is a fourth-generation fluoroquinolone antibiotic available for ophthalmic use. It inhibits two enzymes involved in bacterial DNA synthesis, covering Gram-positive and Gram-negative pathogens. This spectrum allows for the formulation of self-preserving bottle solutions, while its interesting pharmacological profile is distinguished by efficacy at low tissue concentrations and by an infrequent dose regimen due to its long duration on ocular tissues. This enhances patient compliance, promoting its use in children. The human eye hosts several microorganisms; this collection is called the ocular microbiota, which protects the ocular surface, assuring homeostasis. When choosing an antibiotic, it is appropriate to consider its influence on microbiota. A short dose regimen is preferred to minimize the impact of the drug. Moxifloxacin eyedrops represent an effective and safe tool to manage and prevent ocular infections. As healthcare providers face the complexity of the ocular microbiota and microbial resistance daily, the informed use of moxifloxacin is necessary to preserve its efficacy in the future. In this regard, it is well known that moxifloxacin has a lower capacity to induce resistance (an optimal WPC and MPC) compared to other quinolones, but much still needs to be explored regarding the impact that fluoroquinolones could have on the ocular microbiota.

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Section: Optimizing Ocular Infection Treatment: Preserving the Ocular...mentioning

confidence: 99%

Topical Antibiotic Therapy in the Ocular Environment: The Benefits of Using Moxifloxacin Eyedrops

Drago

2024

Microorganisms

View full text Add to dashboard Cite

show abstract

Temporal impacts of topical ceftazidime and tobramycin-vancomycin mixtures on the ocular surface microbiota in rabbits

Cited by 1 publication

References 53 publications

Topical Antibiotic Therapy in the Ocular Environment: The Benefits of Using Moxifloxacin Eyedrops

Topical Antibiotic Therapy in the Ocular Environment: The Benefits of Using Moxifloxacin Eyedrops

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