Temporal glucose metabolism in borderline personality disorder

Fuente, José Manuel De la; Lotstra, Françoise; Goldman, Serge; Biver, Françoise; Luxen, André; Bidaut, Luc; Stanus, Etienne; Mendlewicz, Julien

doi:10.1016/0925-4927(94)90017-5

Cited by 20 publications

(5 citation statements)

References 27 publications

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“…One study using FDG found no differences in temporal glucose metabolism in subjects with BPD compared to healthy volunteers (De La Fuente et al, 1994). Similarly, a study using a FEN challenge design (Siever et al, 1999) has shown that impulsive aggressive patients have no differences in temporal rCMRglu compared to normal controls after placebo administration.…”

Section: Temporoparietal Cortical Region In Mdd With Bpd Compared To mentioning

confidence: 99%

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and without Borderline Personality Disorder

Oquendo

Krunic

Parsey

et al. 2005

Neuropsychopharmacol

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Previous neuroimaging studies of major depression have not controlled for the presence of personality disorders characterized by impulsive aggressive behavior, such as borderline personality disorder (BPD). Using positron emission tomography (PET), we studied regional glucose uptake in response to fenfluramine (FEN) in depressed subjects with BPD (n ¼ 11) and depressed patients without Cluster B Axis II disorders (n ¼ 8). Subjects were scanned while medication-free after a single blind placebo administration and after FEN on a second day. Brain responses were measured by PET imaging of [ 18 F]fluorodeoxyglucose (FDG) and serial prolactin levels. Scans were compared at a voxel level using statistical parametric mapping. Correlations of changes in relative regional cerebral uptake (rCMRglu) with clinical measures were assessed. Depressed borderline patients had greater relative activity in parietotemporal cortical regions (BA 40, BA 22, and BA 42) before and after FEN activation compared to those without BPD. They also had less relative uptake in the anterior cingulate cortex (BA 32) at baseline compared to depressed patients without BPD and FEN abolished this difference. Impulsivity was positively correlated with rCMRglu in superior and middle frontal cortex (BA 6 and 44). Hostility was positively correlated with rCMRglu in temporal cortical regions (BA 21 and 22). In conclusions, borderline pathology in the context of a Major Depressive Disorder is associated with altered activity in parietotemporal and anterior cingulate cortical regions. Controlling for the presence of BPD in future imaging studies of mood disorders may elucidate similarities and differences in regional serotonergic function in these two often comorbid disorders.

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Section: Temporoparietal Cortical Region In Mdd With Bpd Compared To mentioning

confidence: 99%

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and without Borderline Personality Disorder

Oquendo

Krunic

Parsey

et al. 2005

Neuropsychopharmacol

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“…1 Research linking BPD to brain dysfunction dates as far back as 1980; however, along with the advent of more refined neuroimaging techniques, the past few years have seen a rapidly growing number of studies investigating the neurobiologic correlates of BPD. 2,3 Investigations of resting-state cerebral blood flow (CBF) and metabolism in patients with BPD have suggested abnormal activation of cortical areas, including prefrontal, cingulate, parietal and temporal regions, 4,5 as well as perfusion and metabolic abnormalities of subcortical structures, such as the basal ganglia and the thalamus. 5,6 Functional magnetic resonance imaging (fMRI) has been increasingly used to characterize the neural correlates of sensory, cognitive and affective processing, as well as the functional neuroanatomy of social cues 7 in patients with BPD, suggesting several loci of neural dysfunction, most notably in prefrontal areas and limbic regions.…”

Section: Introductionmentioning

confidence: 99%

Aberrant connectivity of resting-state networks in borderline personality disorder

Wolf

Sambataro

Vasić

et al. 2011

jpn

108

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Background: Several functional neuroimaging studies have reported regionally abnormal activation of the frontal cortex in individuals with borderline personality disorder (BPD) during cognitive and affective task performance. However, little is known about neural function in individuals with BPD during the resting state. Using functional magnetic resonance imaging (fMRI), this study investigated the functional connectivity of prefrontal and limbic networks in patients with BPD. Methods: Between January 2009 and March 2010, we investigated patients with BPD according to DSM-IV criteria and healthy controls by means of resting-state fMRI. The data were analyzed using a spatial group independent component analysis, and random effects t tests were used to compare spatial components between groups (p < 0.005, uncorrected). Results: There were 17 women with BPD and 17 female healthy controls enrolled in this study. Within a network comprising cortical midline regions ("default mode network"), patients with BPD showed an increase in functional connectivity in the left frontopolar cortex (FPC) and the left insula, whereas decreased connectivity was found in the left cuneus. Within a network comprising predominantly right lateral prefrontal and bilateral parietal regions, patients with BPD showed decreased connectivity of the left inferior parietal lobule and the right middle temporal cortex compared with healthy controls. Two networks comprising lateral prefrontal and cingulate regions did not exhibit significant between-group differences. We found correlations between functional connectivity of the FPC and measures of impulsivity as well as between connectivity of the insula/cuneus and dissociation tension. Limitations: Co-occurrent axis I disorders and medication use in this sample of patients with BPD have to be considered as potential limitations. Conclusion: These data suggest that abnormal functional connectivity of temporally coherent resting-state networks may underlie certain symptom clusters in patients with BPD

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“…Three studies found no significant difference between BPD and control subjects in general temporal lobe volume [18•,20,31•], nor did temporal lobe baseline metabolism differ between patients with BPD and healthy control subjects [35]. However, portions of the temporal lobes were more active in patients with BPD when hearing scripts of childhood abuse and neglect as compared to a control group [27,28].…”

Section: Other Brain Structuresmentioning

confidence: 97%

Neuroimaging and personality disorders

McCloskey

Phan²,

Coccaro³

2005

Curr Psychiatry Rep

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Within the past several years, neuroimaging research on personality disorders has begun to develop. Personality disorders can be thought of as trait-like dysfunctional patterns in cognitive, affective, impulse control, and interpersonal domains. These domains of dysfunction have been linked to specific neural circuits. Developments in brain imaging techniques have allowed researchers to examine the neural integrity of these circuits in personality-disordered individuals. This article reviews the neuroimaging literature on borderline personality disorder, antisocial personality disorder (including psychopathy) and schizotypal personality disorder. Functional and structural studies provide support for dysfunction in fronto-limbic circuits in borderline and antisocial personality disorder, whereas temporal lobe and basal striatal-thalamic compromise is evident in schizotypal personality disorder.

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Temporal glucose metabolism in borderline personality disorder

Cited by 20 publications

References 27 publications

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and without Borderline Personality Disorder

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and without Borderline Personality Disorder

Aberrant connectivity of resting-state networks in borderline personality disorder

Neuroimaging and personality disorders

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