Temporal expression of G-protein-coupled receptor 54 (GPR54), gonadotropin-releasing hormones (GnRH), and dopamine receptor D2 (drd2) in pubertal female grey mullet, Mugil cephalus

Nocillado, Josephine; Levavi‐Sivan, Berta; Carrick, F. N.; Elizur, Abigail

doi:10.1016/j.ygcen.2006.09.008

Cited by 115 publications

(62 citation statements)

References 52 publications

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“…Likewise, cyclic KiSS-1 gene expression and kisspeptin-IR has been demonstrated in rat oviduct (18). Moreover, ovarian expression of GPR54 has been also recently documented in fish (10,31). Taken together, these observations are suggestive of a potential (and, likely, evolutionary conserved) role of kisspeptins in the local control of ovarian function (38).…”

mentioning

confidence: 74%

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction

Gaytán¹,

Gaytán²,

Castellano³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

153

109

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confidence: 74%

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction

Gaytán¹,

Gaytán²,

Castellano³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

153

109

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“…Expression levels of kiss and kissr in the brain and, to a lesser extent, in the gonad have been analyzed in several non-mammalian species, including amphibians (Chianese et al 2013) and fish (Mohamed et al 2007, Nocillado et al 2007, Biran et al 2008, Filby et al 2008, van Aerle et al 2008, Kitahashi et al 2009, Mechaly et al 2009, Migaud et al 2012, Alvarado et al 2013, Ohga et al 2013, suggesting a putative role for kisspeptins in controlling reproduction. Moreover, in vivo studies in some teleosts have found that the systemic administration of kisspeptin forms induces detectable biological responses at brain and pituitary levels, with potencies depending on the species (Filby et al 2008, Felip et al 2009, Kitahashi et al 2009, Li et al 2009, Shi et al 2010, Espigares et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Differential activation of kiss receptors by Kiss1 and Kiss2 peptides in the sea bass

et al. 2015

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Two forms of kiss gene (kiss1 and kiss2) have been described in the teleost sea bass. This study assesses the cloning and characterization of two Kiss receptor genes, namely kissr2 and kissr3 (known as gpr54-1b and gpr54-2b, respectively), and their signal transduction pathways in response to Kiss1 and Kiss2 peptides. Phylogenetic and synteny analyses indicate that these paralogs originated by duplication of an ancestral gene before teleost specific duplication. The kissr2 and kissr3 mRNAs encode proteins of 368 and 378 amino acids, respectively, and share 53.1% similarity in amino acid sequences. In silico analysis of the putative promoter regions of the sea bass Kiss receptor genes revealed conserved flanking regulatory sequences among teleosts. Both kissr2 and kissr3 are predominantly expressed in brain and gonads of sea bass, medaka and zebrafish. In the testis, the expression levels of sea bass kisspeptins and Kiss receptors point to a significant variation during the reproductive cycle. In vitro functional analyses revealed that sea bass Kiss receptor signals are transduced both via the protein kinase C and protein kinase A pathway. Synthetic sea bass Kiss1-15 and Kiss2-12 peptides activated Kiss receptors with different potencies, indicating a differential ligand selectivity. Our data suggest that Kissr2 and Kissr3 have a preference for Kiss1 and Kiss2 peptides, respectively, thus providing the basis for future studies aimed at establishing their physiologic roles in sea bass. . To date, a single ligand (Kiss) and receptor (Gpr54 or Kissr) have been demonstrated to exist in placental mammals (human, opossum) and reptiles, while mammalian monotrems (platypus) possess two forms of Kiss and Kissr genes. Contrasting situations are found in other tetrapodes, such as amphibians, which have three kiss and kissr genes, whereas the kisspeptin system is absent in birds, although a recent investigation into the kisspeptin system in avian lineages provides molecular evidence of the presence of a kiss2-like gene that degenerated and lost its function (Pasquier et al. 2014b). All in all, advances in genome sequencing and comparative genomics in several groups occupying relevant phylogenetic positions have led to the identification of four kissr and three kiss genes in the coelacanth (Sarcopterygian), while in teleosts at least one kiss and kissr is known to be present in all the species investigated to date. Nevertheless, a second gene for kisspeptin and its receptor has been observed in the genomes of other fish species (Biran et al. 2008, Akazome et al. 2010, Oakley et al. 2010, Um et al. 2010, Zohar et al. 2010, Kim et al. 2012, Pasquier et al. 2012a,b, Tena-Sempere et al. 2012. So far, the occurrence of three kissr and two kiss paralogous genes has been reported in an early group of teleosts, the Elopomorphs (European eel, Anguilla anguilla) (Pasquier et al. 2012a,b). In the spotted gar, Lepisosteus oculatus (Actinopterygian, Ginglymode), four kissr and two kiss have been identified, while four kiss but n...

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“…While the GPR54 gene has been cloned and characterized in several fish species (Parhar et al, 2004;Mohamed et al, 2007;Nocillado et al, 2007;Biran et al, 2008;Filby et al, 2008;Mechaly et al, 2008;van Aerle et al, 2008) and Xenopus (Moon et al, 2008), to date molecular cloning of KiSS-1 is restricted to zebrafish (Danio rerio) (Biran et al, 2008;van Aerle et al, 2008) and medaka (Oryzias latipes) (Kanda et al, 2008). Yet, bioinformatic approaches have been recently used to identify the KiSS-1 gene in different mammals (Biran et al, 2008;Moon et al, 2008;van Aerle et al, 2008), Xenopus (Biran et al, 2008;Moon et al, 2008) and non-mammalian species, including the sea lamprey and teleost fish (Biran et al, 2008;Moon et al, 2008;van Aerle et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

Felip

Zanuy

Pineda

et al. 2009

Molecular and Cellular Endocrinology

204

182

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Temporal expression of G-protein-coupled receptor 54 (GPR54), gonadotropin-releasing hormones (GnRH), and dopamine receptor D2 (drd2) in pubertal female grey mullet, Mugil cephalus

Cited by 115 publications

References 52 publications

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction

Differential activation of kiss receptors by Kiss1 and Kiss2 peptides in the sea bass

Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals

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