Temporal Effects of Drug and Placebo in Delaying Relapse in Schizophrenic Outpatients

Hogarty, Gerard E.; Ulrich, Richard F.

doi:10.1001/archpsyc.1977.01770150055005

Cited by 150 publications

(39 citation statements)

References 15 publications

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“…Similar pattern of result was reported by Hogarty et al (1977). 10 Regarding marital status, among relapse cases, 56(56%) were unmarried, 36(36%) were married, 8(8%) were divorced or separated. On the contrary, among non-relapse cases, 54 (54%) were unmarried, 45(45%) married and 1(1%) divorced.…”

Section: Discussionsupporting

confidence: 83%

Factors associated with relapse of schizophrenia

Haque

Kamal²,

Laila³

et al. 2018

Bang J Psychiatry

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Schizophrenia is a chronic psychiatric illness with high rate of relapse which is commonly associated with noncompliance of medicine, as well as stress and high expressed emotions. The objective of the study was to determine the factors of relapse among the schizophrenic patients attending in outpatient departments of three tertiary level psychiatric facilities in Bangladesh. This was a cross sectional study conducted from July, 2001 to June, 2002. Two hundred patients including both relapse and nonrelapse cases of schizophrenia and their key relatives were included by purposive sampling. The results showed no statistically significant difference in terms of relapse with age, sex, religion, residence, occupation and level of education (p>0.05), but statistically significant difference was found with marital status and economic status (p<0.01). The proportion of non-compliance was found to be 80% and 14%, of high expressed emotion was 17% and 2% and of the occurrence of stressful life events was 10% and 1% in relapse and non-relapse cases respectively which were statistically significant (p<0.001). The study indicated that stressful life events, high expressed emotion, and noncompliance with medication had a role in schizophrenic patients for its relapse.Bang J Psychiatry December 2015; 29(2): 59-63

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Section: Discussionsupporting

confidence: 83%

Factors associated with relapse of schizophrenia

Haque

Kamal²,

Laila³

et al. 2018

Bang J Psychiatry

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“…The cutoff points of 6.0 mmol/l for K+ and 2.5 mmol/l for P0 4 were selected because these are used in the unit to indicate the need for major intervention.…”

Section: Methodsmentioning

confidence: 99%

“…Noncompliance has been shown to be a common cause of relapse in many conditions, for example, in bipolar patients on lithium (1), depressed subjects on antidepressants (2), schizophrenia patients on neuroleptics (3,4), and nephrology patients who have received a kidney transplant (5). It has been found that around 50% ofgeneral medical patients (6), 50% ofpsychiatric patients (3), and an average of 33% of hemodialysis pa- (7) fail to comply with the basic requirements of the treatment regimen.…”

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confidence: 99%

Clinical Rating of Compliance in Chronic Hemodialysis Patients

1999

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A ssessing and measuring patient compliance is assuming increasing importance in clinical practice. Noncompliance has been shown to be a common cause of relapse in many conditions, for example, in bipolar patients on lithium (1), depressed subjects on antidepressants (2), schizophrenia patients on neuroleptics (3,4), and nephrology patients who have received a kidney transplant (5). It has been found that around 50% ofgeneral medical patients (6), 50% ofpsychiatric patients (3), and an average of 33% of hemodialysis pa- tients (7) fail to comply with the basic requirements of the treatment regimen.Compliance is commonly assessed by asking the patient whether he or she is following the prescribed treatment plan. However, for various reasons patient reports are often unreliable. With reference to medication compliance, reliability is improved by counting pills left over after prescribing known quantities of drugs or by talking to friends and nextofkin. Various electronic devices are available to monitor medication-taking (8). Where feasible, biological measures are used to confirm or corroborate clinical evaluations (9).This latter study noted that clinical ratings tended to beinaccurate and overestimated the degree of compliance in 50% of patients. In dialysis patients, however, nurses' ratings of compliance have been found to be valid and reliable (10). Conversely, biological ratings are intrusive, expensive, and cumbersome, and in the case of psychiatric populations, blood levels of neuroleptics and most antidepressants correlate poorly with clinical effectiveness. A clinical ratingthat was easy to administer, combined subjective report withbehavioural evaluation, and was reliable and valid would be valuable and time-saving in clinical practice. It would also

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“…FPE emphasizes partnering and joining with family members and incorporating family members' and patients' goals as the core of the treatment plan. FPE for schizophrenia was heavily influenced by findings that psychotic relapse is a major impediment to longer term clinical and functional improvement 48 . But after roughly a year of remission, most people with schizophrenia make significant functional gains, are more resistant to stress, and can tolerate increasing mental and physical demands.…”

Section: Types Of Psychoeducation Programsmentioning

confidence: 99%

Psychoeducation for Psychotic Patients

Praško¹,

Vrbová²,

Látalová³

et al. 2011

BIOMED PAP

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Background. Psychoeducation programs have been shown in the last two decades to significantly improve the post-hospital discharge care of individuals with schizophrenia by demonstrated effects on rehospitalization rates, compliance with medication and knowledge. The benefits of psychoeducation can be sustained for up to seven years although most studies have not shown such enduring benefit. Psychoeducation is a type of psychotherapeutic support that aims to provide broad and adequate information on psychotic disorders for both patients and their families.Method. The purpose of the group psychoeducational program at the Psychiatric clinic in Olomouc is to familiarize patients with the core of the disorder, explain the part played by pharmacotherapy, teach recognition of the warning signs of relapse, to advise on communication problems within families, and finally the training of social skills.Results. Patients perceive the program as meaningful and helpful in better understanding their lives. INTRODUCTIONSchizophrenia is a chronic psychiatric illness affecting 1% to 2% of the population. Unfortunately, suboptimal follow-through with treatment too often leads to a classic revolving-door pattern of relapse and rehospitalization. While the core intervention in schizophrenia remains antipsychotic medication; the limitations of medication alone in symptomatic, relapse prevention, and satisfaction/quality of life terms have long prompted interest in wider forms of management. This aside, in the CATIE study 1 , a naturalistic randomized-controlled trial comparing five antipsychotic compounds, 74% of all patients discontinued their original medication before the end of the 18 months of the first phase of the trial.One inherent deficit in schizophrenicia is an inability to engage appropriately in social and occupational activities. The debilitating effect of this is often a lasting feature of the illness, despite adequate psychopharmacological intervention, often isolating them and making it difficult for them to advocate appropriate social support or community services. Further, studies have found that there is a correlation between poor social functioning and relapse. One of the challenges of this area, is also wide interindividual variability although standardized measures have been developed to rate the social deficits. These assessments have become important tools in the determination of effective non-pharmacological treatment strategies. In addition to long-term pharmacotherapy, quality education is considered an additional important form of assistanc.Family caregivers report high levels of burden related to caring for their mentally ill family members 2 . They may not have the knowledge and skills necessary to take on the caring responsibilities. As a result, patient relapse and readmission are common 3 .Although no evidence of a definitive cause of schizophrenia is yet available, it can be reasonably controlled though the use of pharmacotherapy and psychosocial interventions. Relapse rates (measured by number of h...

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Temporal Effects of Drug and Placebo in Delaying Relapse in Schizophrenic Outpatients

Cited by 150 publications

References 15 publications

Factors associated with relapse of schizophrenia

Factors associated with relapse of schizophrenia

Clinical Rating of Compliance in Chronic Hemodialysis Patients

Psychoeducation for Psychotic Patients

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