Temporal Dynamics of Stress-Induced Alternations of Intrinsic Amygdala Connectivity and Neuroendocrine Levels

Quaedflieg, Conny W.E.M.; Ven, Vincent van de; Meyer, Thomas; Siep, Nicolette; Smeets, Tom

doi:10.1371/journal.pone.0124141

Cited by 84 publications

(77 citation statements)

References 71 publications

(90 reference statements)

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“…Anatomical differences in this circuitry have been linked to negative affect 49 , and altered functional connectivity within this circuitry has been linked to anxiety 50 . Further, the finding of greater connectivity between amygdala and mPFC during negative vs. neutral affect mirrors recent evidence of enhanced AMYG – mPFC coupling following a psychosocial stressor, particularly in cortisol responders 51 . Although we are unable to determine causality in our study, we speculate, as have others, this may partially reflect the role of the mPFC in inhibiting the arousal response of AMYG during processing of negative emotional stimuli 11,52 .…”

Section: Discussionsupporting

confidence: 73%

Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses

Marečková

Holsen

Admon

et al. 2016

Human Brain Mapping

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Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging (fMRI) study to examine the neural responses to negative valence/high arousal and neutral valence/low arousal images as a function of dysphoric mood and sex across individuals (n=99) who represented traditional categories of healthy controls, major depressive disorder, bipolar psychosis, and schizophrenia. Observation of negative (vs. neutral) stimuli elicited BOLD responses in the following circuitry: periaqueductal gray [PAG], hypothalamus [HYPO], amygdala [AMYG], hippocampus [HIPP], orbitofrontal cortex [OFC], medial prefrontal cortex [mPFC], and greater connectivity between AMYG and mPFC. Across all subjects, severity of dysphoric mood was associated with hyperactivity of HYPO, and, among females, right (R) AMYG. Females also demonstrated inverse relationships between severity of dysphoric mood and connectivity between HYPO - R OFC, R AMYG - R OFC, and R AMYG - R HIPP. Overall, our findings demonstrated sex-dependent deficits in response to negative affective stimuli increasing as a function of dysphoric mood state. Females demonstrated greater inability to regulate arousal as mood became more dysphoric. These findings contribute to elucidating biosignatures associated with response to negative stimuli across disorders and suggest the importance of a sex-dependent lens in determining these biosignatures.

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Section: Discussionsupporting

confidence: 73%

Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses

Marečková

Holsen

Admon

et al. 2016

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Nonetheless, attentional control and emotion regulatory abilities are closely related (Posner & Rothbart, 2013; Zelazo & Cunningham, 2007) and share underlying brain networks (in particular, the ACC and dlPFC; Beauregard et al, 2001; Bush et al, 2000; Ochsner et al, 2002). These regions both show structural (Eden et al, 2015; Johansen-Berg et al, 2008) and functional (Quaedflieg et al, 2015) connectivity with the amygdala. The specificity of the present findings to predictable threat responding may suggest stronger connectivity of ACC and dlPFC with medial CeA than with lateral CeA and BNST.…”

Section: Discussionmentioning

confidence: 99%

“…The major neural substrates of executive control of attention – the ACC and dlPFC – are reliably associated with emotion regulation (Beauregard et al, 2001; Bush et al, 2000; Ochsner et al, 2002) and show connectivity with the amygdala (Eden et al, 2015; Johansen-Berg et al, 2008; Quaedflieg et al, 2015). However, there is little research on whether these structures have differential connectivity with fear vs. anxiety-related subregions of the amygdala and BNST.…”

Section: Introduction*mentioning

confidence: 99%

Relationships among attention networks and physiological responding to threat

Sarapas

Weinberg

Langenecker

et al. 2017

Brain and Cognition

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Although researchers have long hypothesized a relationship between attention and anxiety, theoretical and empirical accounts of this relationship have conflicted. We attempted to resolve these conflicts by examining relationships of attentional abilities with responding to predictable and unpredictable threat, related but distinct motivational process implicated in a number of anxiety disorders. Eighty-one individuals completed a behavioral task assessing efficiency of three components of attention – alerting, orienting, and executive control (Attention Network Test - Revised). We also assessed startle responding during anticipation of both predictable, imminent threat (of mild electric shock) and unpredictable contextual threat. Faster alerting and slower disengaging from non-emotional attention cues were related to heightened responding to unpredictable threat, whereas poorer executive control of attention was related to heightened responding to predictable threat. This double dissociation helps to integrate models of attention and anxiety and may be informative for treatment development.

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“…One study that lends insight into this issue is that performed by Quaedflieg and colleagues (Quaedflieg et al, 2015). These investigators showed that cortisol responders and non-responders exhibited opposite patterns of connectivity changes in amygdala-prefrontal cortex (PFC) and amygdala-hippocampus circuits during and following acute stress.…”

Section: Discussionmentioning

confidence: 99%

Blunted cortisol response to acute pre-learning stress prevents misinformation effect in a forced confabulation paradigm

Zoladz

Cadle

Dailey

et al. 2017

Hormones and Behavior

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Research examining the effects of stress on false memory formation has been equivocal, partly because of the complex nature of stress-memory interactions. A major factor influencing stress effects on learning is the timing of stress relative to encoding. Previous work has shown that brief stressors administered immediately before learning enhance long-term memory. Thus, we predicted that brief stress immediately before learning would decrease participants’ susceptibility to subsequent misinformation and reduce false memory formation. Eighty-four male and female participants submerged their hand in ice cold (stress) or warm (no stress) water for 3 min. Immediately afterwards, they viewed an 8-min excerpt from the Disney movie Looking for Miracles. The next day, participants were interviewed and asked several questions about the video, some of which forced them to confabulate responses. Three days and three weeks later, respectively, participants completed a recognition test in the lab and a free recall test via email. Our results revealed a robust misinformation effect, overall, as participants falsely recognized a significant amount of information that they had confabulated during the interview as having occurred in the original video. Stress, overall, did not significantly influence this misinformation effect. However, the misinformation effect was completely absent in stressed participants who exhibited a blunted cortisol response to the stress, for both recognition and recall tests. The complete absence of a misinformation effect in non-responders may lend insight into the interactive roles of autonomic arousal and corticosteroid levels in false memory development.

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Temporal Dynamics of Stress-Induced Alternations of Intrinsic Amygdala Connectivity and Neuroendocrine Levels

Cited by 84 publications

References 71 publications

Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses

Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses

Relationships among attention networks and physiological responding to threat

Blunted cortisol response to acute pre-learning stress prevents misinformation effect in a forced confabulation paradigm

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