“…The lack of oligoclonal bands restricted to the CSF, the absence of periventricular lesions, variations in clinical symptoms, and the clinical evolution of ADEM are not in favor of Multiple Sclerosis (MS), although requiring a long follow-up for ruling out the dissemination in time which is the core characteristic of MS [ 58 ]. In addition, memory impairments, seizures, and psychiatric symptoms along with the presence of autoantibodies which are the typical manifestations of autoimmune encephalitis are not common features in ADEM [ 59 ]. The MOG antibody–associated disorder (MOGAD) consists of ADEM, transverse myelitis, and optic neuritis.…”