Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson’s disease

Araújo-Silva, Fabiana; Santinelli, Felipe Balistieri; Imaizumi, Luis Felipe Itikawa; Silveira, Aline P.B.; Vieira, Luiz Henrique Palucci; Alcock, Lisa; Barbieri, Fábio Augusto

doi:10.1016/j.brainres.2021.147727

Cited by 8 publications

(2 citation statements)

References 65 publications

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“…To be considered ON condition, participants had taken dopaminergic medication 1 h before starting the session to ensure dose stabilization. In the OFF condition, the participants spent at least 12 h without medication for Parkinson’s disease ( Araujo-Silva et al, 2022 ). The order of the sessions was randomized among the patients.…”

Section: Methodsmentioning

confidence: 99%

A public data set of walking full-body kinematics and kinetics in individuals with Parkinson’s disease

Shida

Costa²,

Oliveira³

et al. 2023

Front. Neurosci.

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BackgroundTo our knowledge, there is no Parkinson’s disease (PD) gait biomechanics data sets available to the public.ObjectiveThis study aimed to create a public data set of 26 idiopathic individuals with PD who walked overground on ON and OFF medication.Materials and methodsTheir upper extremity, trunk, lower extremity, and pelvis kinematics were measured using a three-dimensional motion-capture system (Raptor-4; Motion Analysis). The external forces were collected using force plates. The results include raw and processed kinematic and kinetic data in c3d and ASCII files in different file formats. In addition, a metadata file containing demographic, anthropometric, and clinical data is provided. The following clinical scales were employed: Unified Parkinson’s disease rating scale motor aspects of experiences of daily living and motor score, Hoehn & Yahr, New Freezing of Gait Questionnaire, Montreal Cognitive Assessment, Mini Balance Evaluation Systems Tests, Fall Efficacy Scale-International–FES-I, Stroop test, and Trail Making Test A and B.ResultsAll data are available at Figshare (https://figshare.com/articles/dataset/A_dataset_of_overground_walking_full-body_kinematics_and_kinetics_in_individuals_with_Parkinson_s_disease/14896881).ConclusionThis is the first public data set containing a three-dimensional full-body gait analysis of individuals with PD under the ON and OFF medication. It is expected to contribute so that different research groups worldwide have access to reference data and a better understanding of the effects of medication on gait.

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Section: Methodsmentioning

confidence: 99%

A public data set of walking full-body kinematics and kinetics in individuals with Parkinson’s disease

Shida

Costa²,

Oliveira³

et al. 2023

Front. Neurosci.

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show abstract

“…People with PD performed the evaluations during the ON-medication state (one hour after the participants had taken their dopaminergic medication 23 ). The participants were evaluated on two different days (three to five days apart): i) day 1 -clinical and gait evaluation; ii) day 2 -body composition evaluation.…”

Section: Experimental Protocolmentioning

confidence: 99%

Gait velocity and stability are correlated to muscle and bone mass loss in people with Parkinson’s disease: a preliminary study

Barbieri¹,

Faria

Similei

et al. 2022

BJMB

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Background: Parkinson’s disease (PD) exacerbates muscle and bone mass loss, which is associated with several negative outcomes such as falls and disability. Thus, muscle and bone mass loss may be one mechanism for the mediator role between gait impairments and PD. Aim: To verify the relationship between the spatial-temporal gait parameters and the body composition of the lower limbs in people with PD. Method: Thirteen people with PD were evaluated on two different days: i) clinical and gait evaluation; ii) body composition evaluation. The step length, width, duration and speed, the percentage in double support, and gait velocity during walking at self-selected velocity. Dual-energy X-ray absorptiometry technique was used to measure fat mass, lean mass, bone mass, and the total mass, for whole body, and separately for each limb. Pearson’s correlation coefficients were applied between the spatial-temporal gait parameters and the variables of body composition of lower limbs. Results: Reduced lean and bone mass of both legs were related to faster gait velocity (r=0.6, p<0.03 and r=0.7, p<0.01, respectively) and step speed (r=0.5, p<0.05 and r=0.65, p<0.02, respectively). Also, narrower step width was related to the higher bone mass of both legs (r=0.6, p<0.03). However, muscle and bone mass did not correlate with step length and duration, and percentage of double support. Interpretation:Our findings suggest that the muscle and bone mass of the lower limbs are important body characteristics for gait impairments in people with PD and should be monitored over the disease.

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Postural control of prolonged standing in people with Parkinson's disease

Coelho,

Mochizuki,

Moreno

et al. 2024

Human Movement Science

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Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson’s disease

Cited by 8 publications

References 65 publications

A public data set of walking full-body kinematics and kinetics in individuals with Parkinson’s disease

A public data set of walking full-body kinematics and kinetics in individuals with Parkinson’s disease

Gait velocity and stability are correlated to muscle and bone mass loss in people with Parkinson’s disease: a preliminary study

Postural control of prolonged standing in people with Parkinson's disease

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