Temporal Dynamics Assessment of Spatial Overlap Pattern of Functional Brain Networks Reveals Novel Functional Architecture of Cerebral Cortex

Jiang, Xi; Li, Xiang; Lv, Jinglei; Zhao, Shijie; Zhang, Shu; Zhang, Wei; Zhang, Tuo; Han, Junwei; Guo, Lei; Liu, Tianming

doi:10.1109/tbme.2016.2598728

Cited by 36 publications

(35 citation statements)

References 41 publications

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“…A quantitative examination of gyral folding patterns across primate species showed that the gyral complexity successively expressed from macaque brain to human brain (Chen et al, 2013; Li et al, 2016). We also found different connectivity patterns (Nie et al, 2012; Zhang et al, 2014) and functional roles (Deng et al, 2013; Jiang et al, 2016) between gyri and sulci. In addition, new computational models were proposed to study the mechanisms that regulate gyral development by simulating the process (Nie et al, 2010; Zhang et al, 2016).…”

Section: Introductionmentioning

confidence: 67%

Gyral net: A new representation of cortical folding organization

Chen

et al. 2017

Medical Image Analysis

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One distinct feature of the cerebral cortex is its convex (gyri) and concave (sulci) folding patterns. Due to the remarkable complexity and variability of gyral/sulcal shapes, it has been challenging to quantitatively model their organization patterns. Inspired by the observation that the lines of gyral crests can form a connected graph on each brain hemisphere, we propose a new representation of cortical gyri/sulci organization pattern – gyral net, which models cortical architecture from a graph perspective, starting with nodes and edges obtained from the reconstructed cortical surfaces. A novel computational framework is developed to efficiently and automatically construct gyral nets from surface meshes, and four measurements are devised to quantify the folding patterns. Using an MRI dataset for autism study as a test bed, we identified reduced local connectivity cost and increased curviness of gyral net bilaterally on the parietal lobe, occipital lobe, and temporal lobe in autistic patients. Additionally, we found that the cortical thickness and the gyral straightness of gyral joints are higher than the rest of gyral crest regions. The proposed representation offers a new tool for a comprehensive and reliable characterization of the cortical folding organization. This novel computational framework will enable large-scale analyses of cortical folding patterns in the future.

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Section: Introductionmentioning

confidence: 67%

Gyral net: A new representation of cortical folding organization

Chen

et al. 2017

Medical Image Analysis

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“…In fact, 3-hinges are of unique structural and functional importance in terms of structural and functional features, brain development and brain evolution, and has the potential to determine inter-subject correspondence (Li, et al 2010; Nie et al 2011; Li, et al, 2015; Chen et al 2012; Chen et al 2014; Zhang et al 2014; Yu et al 2013; Li et al, 2017; Jiang et al, 2015; Jiang et al, 2016a; Jiang et al, 2016b; Ge et al, 2017; Liu et al, 2017). In our previous works (Figure S7 and Table S3), it has been demonstrated that 3-hinges have thicker cortices (Li et al, 2015), higher fiber density and diversities (Li et al 2010; Chen et al 2014; Yu et al 2013; Li et al 2017; Ge et al 2017), and are more strongly functionally connected (Jiang et al 2015; Jiang et al 2016a; Jiang et al 2016b; Liu et al 2017) compared to other gyral regions.…”

Section: Introductionmentioning

confidence: 99%

Exploring 3‐hinge gyral folding patterns among HCP Q3 868 human subjects

Zhang

Chen

Razavi

et al. 2018

Human Brain Mapping

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Comparison and integration of neuroimaging data from different brains and populations are fundamental in neuroscience. Over the past decades, the neuroimaging field has largely depended on image registration to compare and integrate neuroimaging data from individuals in a common reference space, with a basic assumption that the brains are similar. However, the intrinsic neuroanatomical complexity and huge interindividual cortical folding variation remain underexplored. Here we focus on a specific cortical convolution pattern, termed 3-hinge gyral folding, which is the conjunction of gyri from multiple orientations and has unique and consistent anatomically, structurally, and functionally connective patterns across subjects. By developing a novel shape descriptor and a two-stage clustering pipeline, we devise an automatic method to identify 3-hinges in the Human Connectome Project Q3 868 human brains, and further parameterize the complexity of such a pattern and quantify its regularity and variation in terms of 3-hinge number, position, and morphology. Our results not only exhibit the huge interindividual variations, but also reveal regular relationship between gyral hinges and other factors, such as their locations and cortical morphologies. It is found that "line-shape" cortices have relatively more consistent 3-hinge shape pattern distributions, and certain types of 3-hinge patterns favor particular cortical morphologies. In addition, more 3-hinges are found on "line-shape" cortices while their numbers vary more across subjects than those on "non-line-shape" cortices. This study adds new insights into a better understanding of the regularity and variability of human brain anatomy, and their functional aspects.

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“…Inspired by previous anatomical and structural findings and motivated by the fact that DTI-derived the fibers provide the structural substrates for functional activities, recently, more sights have been shifted to explore the differences of functional mechanisms and dynamics between gyri and sulci from a functional perspective (Deng et al, 2014; Jiang et al, 2015; Jiang et al, 2016). For example, Deng and colleagues (Deng et al, 2014) quantitatively characterized the functional model of cortical gyri and sulci of resting-state functional magnetic resonance imaging (rsfMRI) data.…”

Section: Introductionmentioning

confidence: 99%

“…Their experimental results demonstrated that the functional connectivity is strong between gyral-gyral regions, weak between sulcal-sulcal regions, and moderate between gyral-sulcal regions. Another intriguing finding is related to task-based heterogeneous functional regions (THFRs) (Jiang et al, 2015) or spatial overlap patterns of functional networks (SOPFNs) (Jiang et al, 2016). Mounting studies in the neuroscience field reported that there exist multiple concurrent functional networks that are spatially distributed across brain regions and interact with each other (Ashburner and Friston, 2000; Bullmore and Sporns, 2009; Fox et al, 2005; Lv et al, 2015a; Lv et al, 2015b).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, THFRs activated in multiple tasks conditions were found to locate significantly more on gyral regions than on sulcal regions (Jiang et al, 2015). Furthermore, a study based on a sliding-window method reported that spatial overlap patterns of functional networks also mainly locate on gyral regions across different time periods (Jiang et al, 2016). Taken together, the abovementioned studies consistently suggested a possible, common architecture of cerebral cortex that gyri are global structural and functional centers in the cerebral cortex, while sulci are local structural and functional units.…”

Section: Introductionmentioning

confidence: 99%

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Elucidating functional differences between cortical gyri and sulci via sparse representation HCP grayordinate fMRI data

Liu¹,

Jiang²,

Zhang³

et al. 2017

Brain Research

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The highly convoluted cerebral cortex is characterized by two different topographic structures: convex gyri and concave sulci. Increasing studies have demonstrated that cortical gyri and sulci exhibit different structural connectivity patterns. Inspired by the intrinsic structural differences between gyri and sulci, in this paper, we present a data-driven framework based on sparse representation of fMRI data for functional network inferences, then examine the interactions within and across gyral and sulcal functional networks and finally elucidate possible functional differences using graph theory based properties. We apply the proposed framework to the high-resolution Human Connectome Project (HCP) grayordinate fMRI data. Extensive experimental results on both resting state fMRI data and task-based fMRI data consistently suggested that gyri are more functionally integrated, while sulci are more functionally segregated in the organizational architecture of cerebral cortex, offering novel understanding of the byzantine cerebral cortex.

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Temporal Dynamics Assessment of Spatial Overlap Pattern of Functional Brain Networks Reveals Novel Functional Architecture of Cerebral Cortex

Abstract: Moreover, these results help better understand functional dynamics mechanisms of cerebral cortex in the future.

Cited by 36 publications

References 41 publications

Gyral net: A new representation of cortical folding organization

Gyral net: A new representation of cortical folding organization

Exploring 3‐hinge gyral folding patterns among HCP Q3 868 human subjects

Elucidating functional differences between cortical gyri and sulci via sparse representation HCP grayordinate fMRI data

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