Temporal Discrimination Is Abnormal in Parkinson's Disease

Artieda, Julio; Pastor, María A.; Lacruz, Francisco Agramunt; Obeso, J. A.

doi:10.1093/brain/115.1.199

Cited by 374 publications

(323 citation statements)

References 25 publications

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“…This finding is supported by work in Parkinsonian (Artieda et al, 1992;Harrington et al, 1998a;Malapani et al, 1998;Elsinger et al, 2003), and Huntington's disease patients (Paulsen et al, 2004). The well established influence of dopamine upon subjective time measurement has led to the suggestion that the basal ganglia, a cluster of nuclei which are heavily innervated by dopamine, may house a time-dependent process, or at least be involved in timing.…”

Section: Time-dependent Processmentioning

confidence: 62%

“…Single unit recording studies have shown that some cells in the dorsolateral prefrontal cortex behave in a manner consistent with the integrator concept, systematically increasing or decreasing firing rates along a temporally predictable function during measured delay intervals (Niki and Watanabe, 1979;Matell et al, 2003). As discussed above, the suggestion that modulations of this type in dorsolateral prefrontal cortex are used as the time-varying process is in accord with the observed effects of dopamine upon time measurement (Artieda et al, 1992;Harrington et al, 1998a;Meck, 1996;O'Boyle et al, 1996) since dorsolateral prefrontal cortex receives modulatory dopaminergic inputs (Porrino and Goldman-Rakic, 1982). The observation of increased activity in that region during the measurement of a longer interval is also compatible with this scheme and could be interpreted as evidence for recruitment of additional integration or decay functions.…”

Section: Memory Traces As the Time-varying Processmentioning

confidence: 67%

“…Pharmacological work in both humans (Artieda et al, 1992;Harrington et al, 1998a;O'Boyle et al, 1996) and nonhumans (Meck, 1996) has suggested that the time-dependent process is dopamine-linked. This finding is supported by work in Parkinsonian (Artieda et al, 1992;Harrington et al, 1998a;Malapani et al, 1998;Elsinger et al, 2003), and Huntington's disease patients (Paulsen et al, 2004).…”

Section: Time-dependent Processmentioning

confidence: 99%

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A right hemispheric prefrontal system for cognitive time measurement

Lewis

Miall

2006

Behavioural Processes

137

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Despite a growing body of neuroimaging data, little consensus has been reached regarding the neural correlates of temporal processing in humans. This paper presents a reanalysis of two previously published neuroimaging experiments, which used two different cognitive timing tasks and examined both sub-and supra-second intervals. By processing these data in an identical manner, this reanalysis allows valid comparison and contrasting across studies. Conjunction of these studies using inclusive masking reveals shared activity in right hemispheric dorsolateral and ventrolateral prefrontal cortex and anterior insula, supporting a general-purpose system for cognitive time measurement in the right hemispheric prefrontal cortex. Consideration of the patterns of activity in each dataset with respect to the others, and taking task characteristics into account, provides insight into the possible role of dorsolateral prefrontal cortex in working memory and of posterior parietal cortex and anterior cingulate in attentional processing during cognitive time measurement tasks. © 2006 Elsevier B.V. All rights reserved. Timing is crucial to both perception and action. In order to perform flexible, behaviourally relevant time measurement, several quite specific processes seem to be necessary (Staddon and Higa, 1999;Wearden, 1999;Gibbon, 1977). These include a time-varying process which changes at a regular rate, a working memory store which keeps track of this process within each interval measured, retrieval from a reference memory store containing information about prior experience, and a mechanism which can compare current working memory values to these standards. In addition, behavioural data (Casini and Ivry, 1999) strongly support the modulatory role of attention in time measurement. The presence of these five components in a neural clock system is widely accepted (Gibbon et al., 1984;Killeen and Fetterman, 1993;Staddon and Higa, 1999;Triesman, 1963), however, the anatomical loci of the various processes are much disputed.In a recent meta-analysis (Lewis and Miall, 2003b) of 34 neuroimaging datasets examining this topic, we found that tasks involving repetitive, continuous timing such as paced finger tapping, frequently draw upon a different network of brain regions * Corresponding author.E-mail address: plewis@liv.ac.uk (P.A. Lewis).from those involving discrete trials separated by inter-trial intervals. These results imply that continuous timing can be performed more or less automatically by a subsection of the motor system, while discrete timing requires more cognitively controlled processing, especially when the intervals measured are one second or longer, and draws on the right prefrontal and parietal cortices. When studies specifically investigating discrete timing are examined as a group, a pattern characterised by right hemispheric activity in the prefrontal and parietal cortices emerges

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Section: Time-dependent Processmentioning

confidence: 62%

Section: Memory Traces As the Time-varying Processmentioning

confidence: 67%

Section: Time-dependent Processmentioning

confidence: 99%

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A right hemispheric prefrontal system for cognitive time measurement

Lewis

Miall

2006

Behavioural Processes

137

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“…Thus, amygdala neurons have access to an internal clock that processes the time of future reward occurrence. The temporal influence on amygdala neurons might derive from dopamine projections [58] involved in interval timing [59,60].…”

Section: Amygdalamentioning

confidence: 99%

Timing in reward and decision processes

Bermúdez

Schultz

2014

Phil. Trans. R. Soc. B

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Sensitivity to time, including the time of reward, guides the behaviour of all organisms. Recent research suggests that all major reward structures of the brain process the time of reward occurrence, including midbrain dopamine neurons, striatum, frontal cortex and amygdala. Neuronal reward responses in dopamine neurons, striatum and frontal cortex show temporal discounting of reward value. The prediction error signal of dopamine neurons includes the predicted time of rewards. Neurons in the striatum, frontal cortex and amygdala show responses to reward delivery and activities anticipating rewards that are sensitive to the predicted time of reward and the instantaneous reward probability. Together these data suggest that internal timing processes have several well characterized effects on neuronal reward processing.

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“…After initial negative results (Ivry and Keele 1989), several studies have shown and confirmed an impairment on different timing tasks in PD (e.g. Artieda et al 1992;Pastor et al 1992;Harrington et al 1998a), which is especially prominent when patients are taken off dopaminergic medication (Malapani et al 1998). This deficit is not restricted to motor timing, but is also evident in perception, for example in discrimination of temporal intervals (Hellström et al 1997;Rammsayer and Classen 1997).…”

Section: Introductionmentioning

confidence: 99%

Processing of temporal information and the basal ganglia: new evidence from fMRI

et al. 2003

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Temporal information processing is a fundamental brain function, which might include central timekeeping mechanisms independent of sensory modality. Psychopharmacological and patient studies suggest a crucial role of the basal ganglia in time estimation. In this study, functional magnetic resonance imaging (fMRI) was applied in 15 healthy right-handed male subjects performing an auditory time estimation task (duration discrimination of tone pairs in the range of 1,000-1,400 ms) and frequency discriminations (tone pairs differing in pitch, around 1,000 Hz) as an active control task. Task difficulty was constantly modulated by an adaptive algorithm (weighted up-down method) reacting on individual performance. Time estimation (vs rest condition) elicited a distinct pattern of cerebral activity, including the right medial and both left and right dorsolateral prefrontal cortices (DLPFC), thalamus, basal ganglia (caudate nucleus and putamen), left anterior cingulate cortex, and superior temporal auditory areas. Most activations showed lateralisation to the right hemisphere and were similar in the frequency discrimination task. Comparing time and frequency tasks, we isolated activation in the right putamen restricted to time estimation only. This result supports the notion of central processing of temporal information associated with basal ganglia activity. Temporal information processing in the brain might thus be a distributed process of interaction between modality-dependent sensory cortical function, the putamen (with a timing-specific function), and additional prefrontal cortical systems related to attention and memory. Further investigations are needed to delineate the differential contributions of the striatum and other areas to timing.

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Temporal Discrimination Is Abnormal in Parkinson's Disease

Cited by 374 publications

References 25 publications

A right hemispheric prefrontal system for cognitive time measurement

A right hemispheric prefrontal system for cognitive time measurement

Timing in reward and decision processes

Processing of temporal information and the basal ganglia: new evidence from fMRI

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