Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area

Kim, Yong‐Dae; Yim, Dong‐Hyuk; Eom, Sang‐Yong; Moon, Sun-In; Park, Choong-Hee; Kim, Guen-Bae; Yu, Seung-Do; Choi, Byung-Sun; Park, Jung-Duck; Kim, Heon

doi:10.1016/j.etap.2014.10.016

Cited by 25 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chronic Cd exposure can give rise to renal tubular dysfunction and bone damage (18,19). We measured urinary NAG conhttp://dx.doi.org/10.3346/jkms.2016.31.4.489 centration as a marker of renal tubular dysfunction and BMD for bone damage.…”

Section: Discussionmentioning

confidence: 99%

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Kim¹,

Kim²,

Eom³

et al. 2016

ISEE Conference Abstracts

Self Cite

View full text Add to dashboard Cite

Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter in Korea that operated from 1936 to 1989. This study was conducted to evaluate the level of exposure to toxic metals and the potential effect on health in people living near the smelter. The study included 572 adults living within 4 km of the smelter and compared them with 413 controls group of people living similar lifestyles in a rural area approximately 15 km from the smelter. Urinary arsenic (As) level did not decrease according to the distance from the smelter, regardless of gender and working history in smelters and mines. However, in subjects who had no occupational exposure to toxic metals, blood lead (Pb) and cadmium (Cd) and urinary Cd decreased according to the distance from the smelter, both in men and women. Additionally, the distance from the smelter was a determinant factor for a decrease of As, Pb, and Cd in multiple regression models, respectively. On the other hands, urinary Cd was a risk factor for renal tubular dysfunction in populations living near the smelter. These results suggest that Janghang copper smelter was a main contamination source of As, Pb, and Cd, and populations living near the smelter suffered some adverse health effects as a consequence. The local population should be advised to make efforts to reduce exposure to environmental contaminants, in order to minimize potential health effects, and to pay close attention to any health problems possibly related to toxic metal exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Kim¹,

Kim²,

Eom³

et al. 2016

ISEE Conference Abstracts

Self Cite

View full text Add to dashboard Cite

show abstract

“…After storing it at 37°C for 15 min, stopping solution (2 mL) was added to and mixed with it. By using a spectrophotometer, its fluorescence intensities were measured with a wavelength of 580 nm ( 13 , 14 ). Urinary β 2 -MG was measured by using Enzygnost β 2 -MG Micro Kit (Behring Institute, Mannheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

Associations of Low Environmental Exposure to Multiple Metals with Renal Tubular Impairment in Korean Adults

Lim

Choi

et al. 2016

ToxicolRes

Self Cite

View full text Add to dashboard Cite

Recently several studies reported that the renal toxicity of lead (Pb) and cadmium (Cd) may exist in even a low level exposure. In terms of the deterioration of tubular function, it affects the loss of divalent metals and leads to other complications, so renal tubular effect of heavy metals should be well managed. Considering the exposure to heavy metals in reality, it is hard to find the case that human is exposed to only one heavy metal. We designed a cross-sectional study using Korean Research Project on the Integrated Exposure Assessment (KRIEFS) data to investigate the renal effects of multiple metal exposure in general population. We used blood Pb and urinary Cd as exposure measures, and urinary N-acetyl-β-D-glucosaminidase (NAG) and β2-microglobulin (β2-MG) as renal tubular impairment outcome. We conducted linear regression to identify the association between each heavy metal and urinary NAG and β2-MG. And then, we conducted linear regression including the interaction term. Of 1953 adults in KRIEFS (2010~2011), the geometric mean of blood Pb and urinary Cd concentration was 2.21 μg/dL (geometric SD = 1.49 μg/dL) and 1.08 μg/g cr (geometric SD = 1.98 μg/g cr), respectively. In urinary Cd, the strength of the association was also high after adjusting (urinary NAG: β = 0.44, p < 0.001; urinary β2-MG: β = 0.13, p = 0.002). Finally, we identified the positive interactions for the two renal biomarkers. The interaction effect of the two heavy metals of β2-MG was greater than that of NAG. It is very important in public health perspective if the low level exposure to multiple heavy metals has an interaction effect on kidney. More epidemiological studies for the interaction and toxicological studies on the mechanism are needed.

show abstract

“…Ordinarily, the proximal tubule reabsorbs and degrades over 99% of filtered β 2 MG [30]. Because tubulopathies increase E β2MG [31], excessive E β2MG is conventionally interpreted as evidence of reabsorptive dysfunction [35,57,58]. This interpretation is understandable, but we suspect that it is an oversimplification.…”

Section: Discussionmentioning

confidence: 98%

The Source and Pathophysiologic Significance of Excreted Cadmium

Satarug

Vesey

Ruangyuttikarn

et al. 2019

Toxics

View full text Add to dashboard Cite

In theory, the identification of the source of excreted cadmium (Cd) might elucidate the pathogenesis of Cd-induced chronic kidney disease (CKD). With that possibility in mind, we studied Thai subjects with low, moderate, and high Cd exposure. We measured urine concentrations of Cd, ([Cd]u); N-acetyl-β-d-glucosaminidase, a marker of cellular damage ([NAG]u); and β2-microglobulin, an indicator of reabsorptive dysfunction ([β2MG]u). To relate excretion rates of these substances to existing nephron mass, we normalized the rates to creatinine clearance, an approximation of the glomerular filtration rate (GFR) (ECd/Ccr, ENAG/Ccr, and Eβ2MG/Ccr). To link the loss of intact nephrons to Cd-induced tubular injury, we examined linear and quadratic regressions of estimated GFR (eGFR) on ECd/Ccr, eGFR on ENAG/Ccr, and ENAG/Ccr on ECd/Ccr. Estimated GFR varied inversely with both ratios, and ENAG/Ccr varied directly with ECd/Ccr. Linear and quadratic regressions of Eβ2MG/Ccr on ECd/Ccr and ENAG/Ccr were significant in moderate and high Cd-exposure groups. The association of ENAG/Ccr with ECd/Ccr implies that both ratios depicted cellular damage per surviving nephron. Consequently, we infer that excreted Cd emanated from injured tubular cells, and we attribute the reduction of eGFR to the injury. We suggest that ECd/Ccr, ENAG/Ccr, and eGFR were associated with one another because each parameter was determined by the tubular burden of Cd.

show abstract

Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area

Cited by 25 publications

References 13 publications

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Associations of Low Environmental Exposure to Multiple Metals with Renal Tubular Impairment in Korean Adults

The Source and Pathophysiologic Significance of Excreted Cadmium

Contact Info

Product

Resources

About