“…These reports have carefully suggested that the change in mitogen-activated protein kinases, myoglobin, and cofilin aids in adaptation to stress induced by cast immobilization and serum-free starvation with a low concentration of glucose. However, further systematic studies in the area of physiotherapy, such as with electro-, neuro-, hydro-, and thermotherapy, are needed to demonstrate the mechanism of HSP27 in muscle atrophic conditions 22 , 23 , 24 , 25 , 26 , 27 ) ( Fig. 1C ).…”