Temporal changes in endolymphatic hydrops on MRI with or without intervention: A systematic review

Mavrommatis, Maria A; Kaul, Vivian F.; Chow, Kevin; Fan, Caleb J.; Bellaire, Christopher P; Cosetti, Maura K.; Wanna, George B.; Pérez, Enrique Guevara

doi:10.1016/j.amjoto.2022.103764

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Those that exist, such as vestibular evoked myogenic potentials or magnetic resonance imaging (Gluth 2020), can be expensive, variable in sensitivity, and time-consuming. In addition, successful application of the magnetic resonance imaging for diagnosis of hydrops requires special protocols involving contrast-enhancement and sophisticated scoring methods (Han et al 2022; Mavrommatis et al 2022; Xiao et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops

2023

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Objectives: Endolymphatic hydrops (EH), a hallmark of Meniere disease, is an inner-ear disorder where the membranes bounding the scala media are distended outward due to an abnormally increased volume of endolymph. In this study, we characterize the joint-otoacoustic emission (OAE) profile, a results profile including both distortion- and reflection-class emissions from the same ear, in individuals with EH and speculate on its potential utility in clinical assessment and monitoring. Design: Subjects were 16 adults with diagnosed EH and 18 adults with normal hearing (N) matched for age. Both the cubic distortion product (DP) OAE, a distortion-type emission, and the stimulus-frequency (SF) OAE, a reflection-type emission, were measured and analyzed as a joint OAE profile. OAE level, level growth (input/output functions), and phase-gradient delays were measured at frequencies corresponding to the apical half of the human cochlea and compared between groups. Results: Normal hearers and individuals with EH shared some common OAE patterns, such as the reflection emissions being generally higher in level than distortion emissions and showing more linear growth than the more strongly compressed distortion emissions. However, significant differences were noted between the EH and N groups as well. OAE source strength (a metric based on OAE amplitude re: stimulus level) was significantly reduced, as was OAE level, at low frequencies in the EH group. These reductions were more marked for distortion than reflection emissions. Furthermore, two significant changes in the configuration of OAE input/output functions were observed in ears with EH: a steepened growth slope for reflection emissions and an elevated compression knee for distortion emissions. SFOAE phase-gradient delays at 40 dB forward-pressure level were slightly shorter in the group with EH compared with the normal group. Conclusions: The underlying pathology associated with EH impacts the generation of both emission types, reflection and distortion, as shown by significant group differences in OAE level, growth, and delay. However, hydrops impacts reflection and distortion emissions differently. Most notably, DPOAEs were more reduced by EH than were SFOAEs, suggesting that pathologies associated with the hydropic state do not act identically on the generation of nonlinear distortion at the hair bundle and intracochlear reflection emissions near the peak of the traveling wave. This differential effect underscores the value of applying a joint OAE approach to access both intracochlear generation processes concurrently.

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Section: Introductionmentioning

confidence: 99%

Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops

2023

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Regression of Endolymphatic Hydrops in Patient With Meniere’s Disease Treated With Vestibular Neurectomy: A Case Report

Jasińska-Nowacka,

Wojciechowski,

Wnuk

et al. 2024

Ear Nose Throat J

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Vestibular neurectomy is an effective method eliminating vertigo attacks in patients suffering from disabling Meniere’s disease with no clinical improvement despite conservative and intratympanic therapy. Magnetic resonance imaging allows in vivo evaluation of changes manifesting in the inner ear after treatment; however, downgrading of the endolymphatic hydrops after vestibular neurectomy had not been previously described in the literature. In the present article, a case of a patient with unilateral severe Meniere’s disease treated with selective vestibular nerve section from middle fossa approach was described. Clinical symptoms and audiovestibular tests were evaluated before and 13 months after the surgery. Complete resolution of vertigo episodes and hearing preservation was achieved. Magnetic resonance imaging was performed before and after the surgery using a 3 Tesla scanner with dedicated protocol after intravenous administration of gadolinium contrast agent. In the follow-up examination, regression of the cochlear and vestibular endolymphatic hydrops was visualized, which may suggest processes occurring in the labyrinth as a result of the vestibular efferent fibers section.

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Temporal changes in endolymphatic hydrops on MRI with or without intervention: A systematic review

Cited by 2 publications

References 29 publications

Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops

Characterizing a Joint Reflection-Distortion OAE Profile in Humans With Endolymphatic Hydrops

Regression of Endolymphatic Hydrops in Patient With Meniere’s Disease Treated With Vestibular Neurectomy: A Case Report

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