Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women

Quinn, Karlee; Cox, Amanda J.; Roberts, Llion A.; Pennell, Evan; McKeating, Daniel R.; Fisher, Joshua J.; Perkins, Anthony V.; Minahan, Clare

doi:10.1007/s00421-021-04734-0

Cited by 13 publications

(22 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Together, these are just two potential mechanisms explaining the trend of longer TL in females compared to males. Our conflicting results could be due to the type of tissue analyzed, the age of the participants sampled, or not accounting for hormonal changes (Quinn et al, 2021 ). Animal model research has found males to have longer TL in all organ tissue except for the brain (Cherif et al, 2003 ).…”

Section: Discussionmentioning

confidence: 94%

“…Lastly, TL has been found to be significantly linked to hormonal levels in females, specifically estrogen and progesterone (Lee et al, 2005 ; Wunderle et al, 2014 ; Shin et al, 2016 ). We did not record time of menses in the athletic population sampled (Quinn et al, 2021 ), a limitation of this study. Further, we did not ask about regularity of menses or signs and symptoms of Relative Energy Deficiency in Sport (RED-S), a syndrome that can affect female athletes training at high-intensity due to an imbalance of dietary energy intake and energy expenditure (previously known as the Female Athlete Triad, but has now been expanded to include multiple aspects of physiological function in athletes) (Nattiv et al, 2007 ; Mountjoy et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Concussion, Sport, and Time in Season on Saliva Telomere Length in Healthy Athletes

Machan

Tabor

Wang

et al. 2022

Front. Sports Act. Living

View full text Add to dashboard Cite

To date, sport-related concussion diagnosis and management is primarily based on subjective clinical tests in the absence of validated biomarkers. A major obstacle to clinical validation and application is a lack of studies exploring potential biomarkers in non-injured populations. This cross-sectional study examined the associations between saliva telomere length (TL) and multiple confounding variables in a healthy university athlete population. One hundred eighty-three (108 male and 75 female) uninjured varsity athletes were recruited to the study and provided saliva samples at either pre- or mid-season, for TL analysis. Multiple linear regression was used to determine the associations between saliva TL and history of concussion, sport contact type, time in season (pre vs. mid-season collection), age, and sex. Results showed no significant associations between TL and history of concussion, age, or sport contact type. However, TL from samples collected mid-season were longer than those collected pre-season [β = 231.4, 95% CI (61.9, 401.0), p = 0.008], and males had longer TL than females [β = 284.8, 95% CI (111.5, 458.2), p = 0.001] when adjusting for all other variables in the model. These findings population suggest that multiple variables may influence TL. Future studies should consider these confounders when evaluating saliva TL as a plausible fluid biomarker for SRC.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

The Impact of Concussion, Sport, and Time in Season on Saliva Telomere Length in Healthy Athletes

Machan

Tabor

Wang

et al. 2022

Front. Sports Act. Living

View full text Add to dashboard Cite

show abstract

“…WomenNC were tested in the mid-luteal phase given this is the only phase that both estradiol and progesterone are elevated simultaneously. WomenOC were tested as late into the active pill-taking days as possible (days 13–18) to minimise data collection during transient shifts in biomarker concentrations that can occur within the first week of pill-taking days after a withdrawal bleed (Quinn et al 2021 ) while minimising the risk of symptoms that may influence exercise effort/motivation in the last week of active pill taking days (Sulak et al 2000 ).…”

Section: Methodsmentioning

confidence: 99%

“…Another factor that may moderate performance is the effect of oral contraceptives (OC) on the redox environment during exercise. Irrespective of training status, OC-use has been consistently associated with oxidative stress and damage measured at rest via blood biomarkers, e.g., elevated malondialdehyde (MDA) and low lipid-soluble antioxidants (Cauci et al 2016 ; De Groote et al 2009 ; Kowalska and Milnerowicz 2016 ; Palan et al 2006 ; Quinn et al 2018 ; Quinn et al 2021 ). Therefore, it could be postulated that oxidative stress is exacerbated in women using OC compared to women naturally cycling during high-intensity exercise.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, the use of NAC as an ergogenic aid has been demonstrated to be more effective in male participants with a glutathione deficiency compared to those with normal or high glutathione levels (Margaritelis et al 2020 ; Paschalis et al 2018 ). As such, the available research suggests that NAC supplementation may have a positive impact on exercise performance for women using OC given there is preliminary evidence demonstrating low glutathione and glutathione peroxidase (GPx) in OC-users at rest (Kowalska and Milnerowicz 2016 ; Quinn et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blood oxidative stress biomarkers in women: influence of oral contraception, exercise, and N-acetylcysteine

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose To compare physiological responses to submaximal cycling and sprint cycling performance in women using oral contraceptives (WomenOC) and naturally cycling women (WomenNC) and to determine whether N-acetylcysteine (NAC) supplementation mediates these responses. Methods Twenty recreationally trained women completed five exercise trials (i.e., an incremental cycling test, a familiarisation trial, a baseline performance trial and two double-blind crossover intervention trials). During the intervention trials participants supplemented with NAC or a placebo 1 h before exercise. Cardiopulmonary parameters and blood biochemistry were assessed during 40 min of fixed-intensity cycling at 105% of gas-exchange threshold and after 1-km cycling time-trial. Results WomenOC had higher ventilation (β [95% CI] = 0.07 L·min−1 [0.01, 0.14]), malondialdehydes (β = 12.00 mmol·L−1 [6.82, 17.17]) and C-reactive protein (1.53 mg·L−1 [0.76, 2.30]), whereas glutathione peroxidase was lower (β = 22.62 mU·mL−1 [− 41.32, − 3.91]) compared to WomenNC during fixed-intensity cycling. Plasma thiols were higher at all timepoints after NAC ingestion compared to placebo, irrespective of group (all p < 0.001; d = 1.45 to 2.34). For WomenNC but not WomenOC, the exercise-induced increase in malondialdehyde observed in the placebo trial was blunted after NAC ingestion, with lower values at 40 min (p = 0.018; d = 0.73). NAC did not affect cycling time-trial performance. Conclusions Blood biomarkers relating to oxidative stress and inflammation are elevated in WomenOC during exercise. There may be an increased strain on the endogenous antioxidant system during exercise, since NAC supplementation in WomenOC did not dampen the exercise-induced increase in malondialdehyde. Future investigations should explore the impact of elevated oxidative stress on exercise adaptations or recovery from exercise in WomenOC.

show abstract

Menstrual Cycle Related Fluctuations in Circulating Markers of Bone Metabolism at Rest and in Response to Running in Eumenorrheic Females

et al. 2022

View full text Add to dashboard Cite

The aim of this study was to investigate potential fluctuations in bone metabolic markers across the menstrual cycle both at rest and after a 30-minute bout of vigorous-intensity running at 80% of 𝑉 ̇O₂max. Resting and post-exercise (0, 30, 90 min) sclerostin (inhibitor of bone formation), parathyroid hormone (PTH, regulator of calcium homeostasis), carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX, marker of bone resorption), and procollagen type 1 N propeptide (P1NP, marker of bone formation) were assessed in 10 young, eumenorrheic women (21.7 ± 3.2 years, 23.2 ± 3 kg . m 2 ) during the mid-to late-follicular (FP: day 8.0 ± 1.4) and midluteal (LP: day 22.0 ± 2.5) phases of the menstrual cycle. Ovulation was determined using ovulation kits and daily measurement of oral body temperature upon awakening. Menstrual phase was subsequently confirmed by measurement of plasma estradiol and progesterone taken on study days, confirming an increase in both hormones during the mid-luteal phase. At rest, there were no

show abstract

Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women

Cited by 13 publications

References 70 publications

The Impact of Concussion, Sport, and Time in Season on Saliva Telomere Length in Healthy Athletes

The Impact of Concussion, Sport, and Time in Season on Saliva Telomere Length in Healthy Athletes

Blood oxidative stress biomarkers in women: influence of oral contraception, exercise, and N-acetylcysteine

Menstrual Cycle Related Fluctuations in Circulating Markers of Bone Metabolism at Rest and in Response to Running in Eumenorrheic Females

Contact Info

Product

Resources

About