Temporal changes and prognostic value of plasma ghrelin level in patients with acute heart failure: a prospective study

Chen, Yanbo; Zhou, S; Zhang, Aiyuan; Huang, Jing; Zhang, Guangfang; Cui, Lianqun

doi:10.1007/s00380-021-01935-7

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Patients with HF often develop the complication of malnutrition due to anabolic/catabolic imbalance and appetite loss, which is partly because of ghrelin resistance [11,12]. Moreover, an association between plasma ghrelin level and prognosis has been reported in patients with HF [13]. In a previous study, ghrelin administration had a promising result for improving patients' nutritional status [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure

Seo

Watanabe

Yamada

et al. 2022

Traditional & Kampo Medicine

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Aim Although malnutrition is an important prognostic factor in patients with chronic heart failure (CHF), no effective treatment for malnutrition has been established. Rikkunshito (RKT) is a Japanese herbal drug that has been used in daily practice for patients with loss of appetite. However, no data have demonstrated whether or not RKT can improve the body composition in patients with CHF. The aim of this study was to elucidate the effect of RKT on the nutritional status of patients with CHF. Methods This single‐center retrospective observational study included 14 patients with CHF and loss of appetite who were treated with RKT. Body mass index (BMI) and body composition including fat‐free mass index (FFMI), skeletal muscle mass index (SMI) and fat mass index (FMI) were measured by the bioimpedance method. Body composition was measured at baseline and 12 weeks later. The primary endpoint was the change of BMI and body composition. Results BMI was significantly improved from 23.7 (20.0–26.1) kg/m2 to 24.2 (20.3–27.3) kg/m2 (p = 0.0494). FFMI was significantly improved from 13.7 (11.3–14.9) kg/m2 to 14.2 (12.0–15.7) kg/m2 (p = 0.0002). SMI was also improved from 5.0 (3.0–6.2) kg/m2 to 5.3 (3.3–6.8) kg/m2 (p = 0.0085). On the other hand, FMI was not significantly changed (9.4 (7.2–12.0) kg/m2 to 10.3 (7.9–12.0) kg/m2, p = 0.8552). Conclusion The Japanese herbal drug RKT was effective in improving the nutritional status of patients with CHF.

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Section: Introductionmentioning

confidence: 99%

Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure

Seo

Watanabe

Yamada

et al. 2022

Traditional & Kampo Medicine

View full text Add to dashboard Cite

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Ghrelin as a promising biological marker in cardiovascular disease

Alieva

Pinchuk

Baykova

et al. 2022

Medical Journal of the Russian Federation

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This review highlights the current literature data on the peptide hormone ghrelin. Ghrelin is a 28-amino-acid peptide, which is the only known peptide hormone modified with fatty acids. Ghrelin is a natural receptor ligand that stimulates the secretion of growth hormones. In addition to the stomach, ghrelin is expressed in many organs such as the duodenum, jejunum, ileum, colon, lungs, heart, pancreas, kidneys, testicles, pituitary gland, and hypothalamus. The main biological functions of this peptide include growth hormone secretion, appetite stimulation, modulation of gastric acid secretion and motility, and an increase in endocrine and exocrine pancreatic secretions. Reference intervals for ghrelin are 8.50216.6 pg/mL. The studies analyzed have shown a strong relationship between ghrelin and cardiovascular system function. Studies have also described the cardioprotective effects of ghrelin. However, the molecular mechanisms underlying the effects of ghrelin on the heart are not fully understood. A further deeper understanding of the role of ghrelin and future clinical studies are necessary to determine the diagnostic, prognostic, and possibly therapeutic significance of this biomarker.

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Temporal changes and prognostic value of plasma ghrelin level in patients with acute heart failure: a prospective study

Cited by 2 publications

References 34 publications

Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure

Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure

Ghrelin as a promising biological marker in cardiovascular disease

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