Temporal Bone Treponemes

Mack, L. W.; Smith, J. Lawton; Walter, E K; Montenegro, Ernesto N. Rios; Nicol, W. G.

doi:10.1001/archotol.1969.00770030013005

Cited by 19 publications

(3 citation statements)

References 5 publications

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“…Although T. pallidum has not developed any measurable penicillin resistance, there have been anecdotal reports of persistence of the organism in aqueous humor, CSF, and inner ear despite treatment with recommended regimens (183,200,201,339). In vitro resistance to erythromycin has been described in a single clinical isolate of T. pallidum from a penicillin-allergic patient who failed treatment with erythromycin (319).…”

Section: Overviewmentioning

confidence: 99%

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

1999

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SUMMARY Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described in 1905, but because of the inability to culture the organism and the limitations of direct microscopy, serologic testing is the mainstay of laboratory diagnosis. The disease has been arbitrarily divided into several stages. The primary stage is defined by a chancre at the site of inoculation. The secondary stage is characterized by a polymorphic rash, lymphadenopathy, and other systemic manifestations. A variable asymptomatic latent period follows, which for epidemiologic purposes is divided into early (<1 year) and late (>1 year) stages. The early stages (primary, secondary, and early latent) are potentially infectious. The tertiary stage is the most destructive and is marked by cardiovascular and neurologic sequelae and gummatous involvement of any organ system. Congenital infection may result in protean early or late manifestations. Unlike many other bacteria causing infectious diseases, the organism remains sensitive to penicillin, and this remains the mainstay of therapy.

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Section: Overviewmentioning

confidence: 99%

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

1999

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“…However, treponema pallidum has not yet been found in perilymph or in endolymph. But, since we became interested in this condition, it has been found (Mack et al, 1969) in the enchondral bone of the labyrinthine capsule (Fig. 10).…”

Section: A G Kerr G D L Smyth and M J Cinnamondmentioning

confidence: 99%

Congenital syphilitic deafness

1973

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“…The question of persistent infection despite adequate therapy has been a controversial subject ever since the first report by Collart (9) in 1962 of the isolation of spirochetes after "appropriate therapy". Although the efficacy of treating T. pallidum with penicillin has not been questioned, there are small numbers of patients in whom the spirochetes become sequestered in areas where adequate levels of penicillin are not easily achieved: for example; the anterior chamber of the eye (10), the central nervous system (11), and the labyrinth of the inner ear (12). Whether these persistent organisms can cause a clinically evident illness at some later date is not known.…”

Section: Discussionmentioning

confidence: 99%

Relapsing Syphilis

Yoon

Haam

Chung

et al. 1993

The Journal of Dermatology

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Although penicillin still remains highly effective for syphilis, concerns have been raised that current regimens may be inadequate for the treatment of early syphilis. We report the failure of benzathine penicillin in the treatment of secondary syphilis. Extensive tracing of sexual contact history failed to identify sources of possible reinfection; therefore, we believe that this case represents a treatment failure and an ensuing relapse of secondary syphilis.

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Temporal Bone Treponemes

Cited by 19 publications

References 5 publications

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

Congenital syphilitic deafness

Relapsing Syphilis

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