Temporal bone carcinoma. Current diagnostic, therapeutic, and prognostic concepts

Lionello, Marco; Stritoni, Paola; Facciolo, Maria Cristina; Staffieri, Alberto; Martini, Alessandro; Mazzoni, Antonio; Zanoletti, Elisabetta; Marioni, Gino

doi:10.1002/jso.23660

Cited by 51 publications

(93 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different classifications have been proposed, 6 but none have been accepted by the International Union Against Cancer (UICC) or the American Joint Committee on Cancer (AJCC). 32 This makes it difficult to compare results and complicates efforts to identify prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

“…Radical surgery is the mainstay of treatment and the status of the margin is one of the most important aspect determining prognosis. Adjuvant radiotherapy has showed improvement in the loco-regional control of advanced disease 6,13 and it is mandatory also after radical surgery.…”

Section: Discussionmentioning

confidence: 99%

“…It is crucial to search for biomarkers that might reflect the biological characteristics of TBSCC and help clinicians to predict the outcome of treatment. 6 For TBSCC such investigations are only just beginning to appear in the oncological literature. Biomarkers could be extremely important to the development of novel, integrated therapeutic strategies (including targeted approaches) capable of improving the DFS and DSS for patients with advanced TBSCC.…”

Section: Discussionmentioning

confidence: 99%

“…4 A role has been hypothesized for chlorinated disinfectants in the etiopathogenesis of middle ear carcinoma and for human papillomavirus in cases of temporal bone squamous cell carcinoma (TBSCC) associated with inverted papilloma. 6,7 TBSCC is usually diagnosed with delay 1,4 since clinical signs (otorrhea, polyps or granulation tissue, hearing loss, bleeding) and patients complaints (ear pain) are similar to other common inflammatory diseases of the ear. When present, facial nerve paralysis is a sign of advanced disease.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence

Zanoletti

Marioni

Franchella

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence

Zanoletti

Marioni

Franchella

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

“…The incidence of primary temporal bone tumours ranges between 0.8-1.0 per 1,00,000 per year and approximately 60-80-% are squamous cell carcinoma. 2 Overall squamous cell carcinoma accounts approximately 1.5% of tympanomastoid tumours. 3,4 Metastatic lesions in tympanomastoid region are very rare and are usually from breast, lung and kidney tumours.…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma of tympano-mastoid region: a series of six cases

Kumar

Garg

Sharma

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

<p class="abstract">The malignancies of tympanomastoid region are very rare entity. These tumours are more common in elderly persons in 6th and 7th decade. Males are more commonly affected than females. Chronically discharging ears are considered as risk factor which may be due to metaplasia in the middle ear mucosa following prolonged chronic infection. The most common symptoms are long standing blood tinged ear discharge, severe nocturnal pain, rapidly growing polypoidal or granulomatous mass in EAC or middle ear, peripheral facial palsy and painless ulceration over pinna or EAC. CT scan for bony erosion and MRI for soft tissue involvement and neural invasion are investigations of choice. Tissue biopsy is must for histopathological examination and confirmation of diagnosis. Surgery and chemo-radiotherapy are the mainstay of treatment. Surgery includes wide local excision, lateral temporal bone resection, subtotal temporal bone resection and total temporal bone resection.</p><p class="abstract"> </p>

show abstract

Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

Background A universally acknowledged cancer staging system considering all aspects of the T‐, N‐, and M‐classifications for middle ear squamous cell carcinoma (MESCC) remains absent, limiting the clinical management of MESCC patients. Materials and Methods A total of 214 MESCC patients were extracted from the SEER (the Surveillance, Epidemiology, and End Results) database between 1973 and 2016. The relationships between patient’s characteristics and prognoses were analyzed by Kaplan–Meier and Cox proportional hazards regression models. Novel staging schemes for MESCC were designed by adjusted hazard ratio (AHR) modeling method according to the combinations of Stell’s T‐classification and the eighth AJCC N‐ and M‐classifications, of which performances were evaluated based on five criteria: hazard consistency, hazard discrimination, explained variation, likelihood difference, and balance. Results T‐classification was the most significant prognostic factor for MESCC patients in multivariable analysis (p = 0.021). The N‐ and M‐classifications also had obvious prognostic effect but were not statistically significant by multivariate analysis due to the limited metastasis events. Three novel staging schemes (AHR‐Ⅰ–Ⅲ models, different combination of T‐ and N‐classifications) and ST (solely derived from Stell’s T‐classification) were developed, among which the AHR‐Ⅰ staging scheme performed best. Conclusions Tumor extension, quantified by Stell’s T‐classification, is the most significant prognostic factor for MESCC patients. However, our AHR‐Ⅰ staging scheme, a comprehensive staging scheme that integrating T‐, N‐, and M‐classifications, might be an optimal option for clinical practitioners to predict MESCC patients’ prognosis and make proper clinical decisions.

show abstract

Temporal bone carcinoma. Current diagnostic, therapeutic, and prognostic concepts

Cited by 51 publications

References 70 publications

Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence

Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence

Squamous cell carcinoma of tympano-mastoid region: a series of six cases

Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma

Contact Info

Product

Resources

About