Temporal bisection in rats: The effects of high‐peak‐power pulsed microwave irradiation

Raslear, Thomas G.; Akyel, Yahya; Bates, F.; Belt, M.; Lu, Shin-Tsu

doi:10.1002/bem.2250140507

Cited by 23 publications

(21 citation statements)

References 35 publications

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“…Thus, the frequency was not responsible for differences in biological findings, but the shorter pulse duration could be. Other factors that should be accounted for are the differences in biological endpoints andpeak intensity of the microwave pulses.The lack of adequate dosimetry in the cited "positive effect" studies makes any comparison questionable at best; but, as far as we could estimate, peak SAR could reach even several GW/kg ], which is an order of magnitude higher than in our work, and 2-3 orders of magnitude higher than in any other EHPP studies of which we are aware Raslear et al, 1993;Jauchem and Frei, 1995]. One may conjecture that induction of EHPP-specific effects would require higher peak SAR combined with much shorter pulses than tried in our study.…”

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confidence: 64%

Services to Operate and Maintain a Microwave Research Laboratory

Akyel¹

2004

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Supplementary Notes (i.e., report contains color photos, report contains appendix in non-print form, etc.) 12a. Distribution/Availability Statement (check one)Approved for public release; distribution unlimited Due to growing concerns for the health and safety of military and civilian personnel exposed to radiofrequency radiation (RFR), a series of research have been performed at the U.S. Army Medical Research Detachment, Microwave Bioeffects Branch at Brooks City-Base, Texas. The research has been concentrated on neurotoxic effects of high peak power but low average power RFR, Interaction between neurotoxin and RFR on manifestation of neurotoxic effects, effects of high power RFR on hippocampus, biological hazards of ultrawide-band (UWB) pulses on cardiovascular function and cell systems, cytotoxic effect of nanosecond high-intensity electric pulses, finite difference time domain techniques for RFR dosimetry, role of ambient temperature on manifestation of RFR induced biological effects, design fabrication and testing a circularly polarized 1.25 GHz waveguide exposure system, and formulate a research plan for body borne and helmet mounted antennas. Majority of results falls in "thermal" effect, albeit, the threshold was at lower magnitude than that previously envisioned. A model is devised to demonstrate the additive effect of RFR to thermal "stress" from ambient environment. On the other hand, some of the observed effects cannot be easily explained by the "thermal" mechanism. They were effects of UWB pulses and nanosecond high power electric pulses.14. Subject Terms (keywords previously assigned to proposal abstract or terms which apply to this award) high peak power pulsed microwaves, ultra-wide-band pulses, neural, Behavior, cardiovascular, cytotoxicity, neurotoxin, genotoxicity References 33Appendices 39 INTRODUCTIONThe following report summarizes the performance of McKesson BioServices Corporation (MBS) staff at the Walter Reed Army Institute of Research (WRAIR), U.S. Army Medical Research Detachment (USAMRD), Microwave Bioeffects Branch at Brooks City-Base, Texas under the contracts DAMD17-94-4069 and DAMD17-94-E-0001. MBS has nine years contract with the U.S. Army Medical Research and Acquisition Activity (USAMRAA) to operate and maintain Microwave Bioeffects Branch, a Government-owned Contractor-operated (GOCO) facility. Reports summarized the base three years (May 21, 1994 -May 20, 1997) (DTIC STINET ADA 351987, http://handle.dtic.mi 1/100.2/ADA351978\ the first option years (May 21, 1997 -May 20, 1999) (DTIC STINET AD A3 67478, http://handle.dfic.mi1/100.2/ADA367478;) and the second opfions years (May 21 1999 -May 20, 2001, DTIC STINET ADA392971, http://handle.dfic.mi1/100.2/ADA39297n were previously filed with the U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland in June 1997, May 1999and May 2001. The present report covers the efforts of MBS staff during the third opfion years (May 21 2001 -May 20, 2003 and extensions (May 21, 2003 -May 31, 2004 of the aforementioned contrac...

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confidence: 64%

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Akyel¹

2004

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“…Other areas of complex behavioral performance such as learning, discrimination, and perception are being investigated and have shown changes that occur at SARs less than that required for disruption of well-learned tasks [Lai, 1994;Luttges, 1980;Raslear et al, 1993].…”

Section: Microwave Effects On Thermoregulatory Mechanismsmentioning

confidence: 99%

“…Raslear et al [1993] exposed rats to high-peak-power pulsed microwaves produced by the TEMPO virtual cathode oscillator. The 3 GHz pulses were 80 nsec in duration with peak power levels varying from Ͻ100 to approximately 700 MW.…”

Section: Effects On Animals' Cognitive Performancementioning

confidence: 99%

Behavioral evaluation of microwave irradiation

D'Andrea

1999

Bioelectromagnetics

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“…The lack of adequate dosimetry in the cited ''positive effect'' studies makes any comparison questionable at best; but, as far as we could estimate, peak SAR could reach even several GW/kg [Deviatkov et al, 1998], which is an order of magnitude higher than in our work, and 2-3 orders of magnitude higher than in any other EHPP studies of which we are aware [Akyel et al, 1991;Raslear et al, 1993;Jauchem and Frei, 1995]. One may conjecture that induction of EHPP-specific effects would require higher peak SAR combined with much shorter pulses than tried in our study.…”

Section: Discussionmentioning

confidence: 46%

Effects of high power microwave pulses on synaptic transmission and long term potentiation in hippocampus

Pakhomov

Doyle

Stuck

et al. 2003

Bioelectromagnetics

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Effects of short, extremely high power microwave pulses (EHPP) on neuronal network function were explored by electrophysiological techniques in the isolated rat hippocampal slice model. Population spikes (PS) in the CA1 area were evoked by repeated stimulation (1 per 30 s) of the Schaffer collateral pathway. A brief tetanus (2 s at 50 Hz) was used to induce long term potentiation (LTP) of synaptic transmission. In three different series of experiments with a total of 160 brain slices, the EHPP irradiation was performed before, during, or after the tetanus. The EHPP carrier frequency was 9.3 GHz, the pulse width and repetition rate were from 0.5 to 2 micros and from 0.5 to 10 Hz, respectively, and the peak specific absorption rate (SAR) in brain slices reached up to 500 MW/kg. Microwave heating of the preparation ranged from 0.5 degrees C (at 0.3 kW/kg time average SAR) to 6 degrees C (at 3.6 kW/kg). The experiments established that the only effect caused by EHPP exposure within the studied range of parameters was a transient and fully reversible decrease in the PS amplitude. Recovery took no more than a few minutes after the cessation of exposure and return to the initial temperature. This effect's features were characteristic of an ordinary thermal response: it was proportional to the temperature rise but not to any specific parameter of EHPP, and it could also be induced by a continuous wave (CW) irradiation or conventional heating. Irradiation did not affect the ability of neurons to develop LTP in response to tetanus or to retain the potentiated state that was induced before irradiation. No lasting or delayed effects of EHPP were observed. The results are consistent with the thermal mechanism of EHPP action and thus far provided no indication of EHPP-specific effects on neuronal function.

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Temporal bisection in rats: The effects of high‐peak‐power pulsed microwave irradiation

Cited by 23 publications

References 35 publications

Services to Operate and Maintain a Microwave Research Laboratory

Services to Operate and Maintain a Microwave Research Laboratory

Behavioral evaluation of microwave irradiation

Effects of high power microwave pulses on synaptic transmission and long term potentiation in hippocampus

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