Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data

Woolrich, Mark W.; Ripley, B. D.; Brady, J. Michael; Smith, Stephen M.

doi:10.1006/nimg.2001.0931

Cited by 2,588 publications

(2,074 citation statements)

References 24 publications

(35 reference statements)

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“…Grandmean intensity normalization (by a single multiplicative factor) and high-pass temporal filtering (using a Gaussian-weighted least-squares straight line fitting, with sigma ¼60.0 s) were performed. FMRIB's Improved Linear Model was used to perform time-series statistical analyses with local autocorrelation correction (Woolrich et al, 2001). FMRIB's Linear Image Registration Tool (Jenkinson and Smith, 2001;Jenkinson et al, 2002) was used to register functional scans via a twostep transformation.…”

Section: Fmri Data Preprocessingmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Fmri Data Preprocessingmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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“…Subject-level time-series statistical analysis was carried out using FILM (FMRIB's Improved Linear Model) with local autocorrelation correction (Woolrich 2001). The three condition events were modeled using a canonical hemodynamic response function and its temporal derivative.…”

Section: Image Processing and Statistical Analysismentioning

confidence: 99%

Brain activation during eye gaze discrimination in stable schizophrenia

Kohler

Loughead

Ruparel

et al. 2008

Schizophrenia Research

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Objective-Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls.Methods-13 schizophrenia and 12 healthy participants underwent a gaze discrimination task with face stimuli rotated at 0, 4 and 8° deviation. During fMRI with BOLD imaging, subjects were asked to identify whether a face was making eye contact. Subject-level parameter estimates for BOLD signal change were entered into an orientation by group mixed effect repeated measures ANOVA.Results-Gaze discrimination performance did not differ between groups. Patients showed decreased activation in areas of bilateral inferior frontal and occipital areas, and select temporo-limbic regions, including amygdala. Groups differed by activation patterns according to gaze deviation. In controls, faces with 4° deviation produced higher activation in frontal and temporal regions. In patients, 0° deviation produced increased activation in amygdala and areas of temporal neocortex.Conclusions-Despite similar gaze discrimination abilities, schizophrenia patients exhibit decreased brain activation in areas associated with executive, emotional and visual processing. Controls exhibited increased activation associated with the more difficult task in select frontal and temporal regions. Patients exhibited increased activation associated with direct gaze in temporal regions, which may relate to common symptoms.

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“…31 For the categorization task three explanatory variables were modelled: 'negative', 'positive' and 'control' words. For the recognition condition two explanatory variables were modelled: 'positive remembered' and 'negative remembered'.…”

Section: Visual Stimulation Paradigmmentioning

confidence: 99%

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

et al. 2007

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Recent neuropsychological studies in healthy volunteers suggest that antidepressants enhance the processing of positive emotional information. However, the neural substrates underpinning these changes have not been fully elucidated. The current study, therefore, used functional magnetic resonance imaging (fMRI) to map brain systems activated during successful categorization and subsequent recognition of self-referent positive and negative personality characteristics in healthy volunteers following short-term (7 days) repeated administration of the selective noradrenergic reuptake inhibitor reboxetine. Twenty-four healthy volunteers were randomly assigned to 7-day double-blind intervention with reboxetine or placebo. On day 7, neural responses during the categorization and subsequent recognition of positive and negative characteristics were assessed using fMRI. Questionnaires monitoring mood, hostility and anxiety were given before and during this intervention. During categorization, reboxetine was associated with greater activation to positive words, relative to negative words, in left precuneus and right inferior frontal gyrus. By contrast, at subsequent recognition reboxetine was associated with reduced response to positive words, relative to negative words, in left precuneus, anterior cingulate and medial frontal gyrus. These changes in the neural processing of positive and negative words occurred in the absence of significant differences in ratings of mood and anxiety. Such adaptations in the neural processing of emotional information support the hypothesis that antidepressants have early effects on emotional processing in a manner which would be expected to reverse negative biases in depression.

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Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data

Cited by 2,588 publications

References 24 publications

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Brain activation during eye gaze discrimination in stable schizophrenia

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

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